Notes in f. Cell Cycle

To Subscribe, use this Key

Status	Last Update	Fields
Published	07/28/2024	{{c1::cyclins}} are regulatory proteins with no enzyme activity, that regulate cell cycle phases as their main function is to bind {{c1::CDK}} protein…
Published	07/28/2024	{{c2::Cdks}} are {{c1::serine/threonine}} kinases that function at different times in the cell cycle to promote phase change
Published	07/28/2024	d45c5b3da60e4c3abae67a5021fb4962-ao-1
Published	07/28/2024	d45c5b3da60e4c3abae67a5021fb4962-ao-2
Published	07/28/2024	d45c5b3da60e4c3abae67a5021fb4962-ao-3
Published	07/28/2024	d45c5b3da60e4c3abae67a5021fb4962-ao-4
Published	07/28/2024	After a cyclin binds to a Cdk, what is required in order to ensure full activation?
Published	07/28/2024	ffab7b6b8e5a4d9e8cfa3bd638b7cd7f-ao-1
Published	07/28/2024	ffab7b6b8e5a4d9e8cfa3bd638b7cd7f-ao-2
Published	07/28/2024	ffab7b6b8e5a4d9e8cfa3bd638b7cd7f-ao-3
Published	07/28/2024	ffab7b6b8e5a4d9e8cfa3bd638b7cd7f-ao-4
Published	07/28/2024	DNA damage activates {{c1::p53}} which induces synthesis of {{c1::p21}} which suppresses {{c2::G1/S (Cdk2,Cyclin E)}} and {{c2::S-(Cdk2,Cyclin A)}} fo…
Published	07/28/2024	Cyclins {{c1:: D,E,A}} and Cdks {{c1::2,4,6}} promote movement through the {{c1::G1/S}} checkpoint. {{c1::p27}} and {{c1::p21}} suppress G1/S-Cdk and …
Published	07/28/2024	Cyclin dependent kinase inhibitors such as p21 and p27 (which prevent cell cycle entry into {{c1::S}} phase are degraded by {{c1::SCF}} initiated…
Published	07/28/2024	Rb is a {{c1::negative::positive/negative}} regulator of transcription as it binds to and {{c1::inactivates}} E2F until it is hyperphosphorylated…
Published	07/28/2024	3e50b26449dc4209b83228ca33030474-ao-1
Published	07/28/2024	3e50b26449dc4209b83228ca33030474-ao-2
Published	07/28/2024	3e50b26449dc4209b83228ca33030474-ao-3
Published	07/28/2024	3e50b26449dc4209b83228ca33030474-ao-4
Published	07/28/2024	Activation of E2F promotes transcription of genes required for the {{c1::G1/S}} progression, including cyclins and proteins required for DNA synt…
Published	07/28/2024	6d23843429834c72b41a4ba564e9d690-oa-1
Published	07/28/2024	6d23843429834c72b41a4ba564e9d690-oa-2
Published	07/28/2024	6d23843429834c72b41a4ba564e9d690-oa-3
Published	07/28/2024	6d23843429834c72b41a4ba564e9d690-oa-4
Published	07/28/2024	6d23843429834c72b41a4ba564e9d690-oa-5
Published	07/28/2024	6d23843429834c72b41a4ba564e9d690-oa-6
Published	07/28/2024	6d23843429834c72b41a4ba564e9d690-oa-7
Published	07/28/2024	6d23843429834c72b41a4ba564e9d690-oa-8
Published	07/28/2024	909130da7fdd4cef8580c11a31c87bac-ao-1
Published	07/28/2024	909130da7fdd4cef8580c11a31c87bac-ao-2
Published	07/28/2024	909130da7fdd4cef8580c11a31c87bac-ao-3
Published	07/28/2024	909130da7fdd4cef8580c11a31c87bac-ao-4
Published	07/28/2024	909130da7fdd4cef8580c11a31c87bac-ao-5
Published	07/28/2024	909130da7fdd4cef8580c11a31c87bac-ao-6
Published	07/28/2024	Mitogen (growth factor) signaling results in transcription factors that produce {{c1::Myc}} regulatory proteins which is a transcription factor t…
Published	07/28/2024	Excessive stimulation of mitogenic pathways induces?
Published	07/28/2024	{{c1::p53}} is a tumor supressor, that when activated will force cell cycle arrest/apoptosis via activation of {{c1::p21}}
Published	07/28/2024	Under normal cellular condition, p53 which is a {{c1::tumor repressor}} is bound to {{c1::Mdm2}} which encourages its degradation and prevents it…
Published	07/28/2024	948d9d0ece6440a1a8f80bca90e8cf29-ao-1
Published	07/28/2024	948d9d0ece6440a1a8f80bca90e8cf29-ao-2
Published	07/28/2024	948d9d0ece6440a1a8f80bca90e8cf29-ao-3
Published	07/28/2024	{{c1::Ataxia telangiectasia mutated (ATM)}} is a master regulator of the response to DNA damage that is in part responsible for p53 activation
Published	07/28/2024	{{c1::M-Phase Promoting Factor (MPF)}} is the complex of cyclin {{c2::B}} and Cdk {{c2::1}} which is responsible for entry into the {{c1::M phase}} wh…
Published	07/28/2024	eff125c31f534855a4badafbe952c346-ao-1
Published	07/28/2024	eff125c31f534855a4badafbe952c346-ao-2
Published	07/28/2024	eff125c31f534855a4badafbe952c346-ao-3
Published	07/28/2024	Wee1 is a CDK {{c1::kinase}} used during MPF activation
Published	07/28/2024	Cdc25 is a CDK {{c1::phosphatase}} which removes the phosphate group from {{c1::Y15}} to activate {{c1::M-phase Promoting Factor MPF}} which is t…
Published	07/28/2024	Cyclin B (m-cyclins) are degraded by {{c1::APC/C (anaphase promoting complex)}} ubiquitinylation (APCC and SCF1 ubiquitinylate cyclins. The switc…
Published	07/28/2024	The three major checkpoints in cell cycle control are the {{c1::G1/S}}, {{c2::G2/M}} and {{c1::metaphase to anaphase}} checkpoints which ensure {{c1::…
Published	07/28/2024	Complexes of {{c1::cyclins}} and {{c1::cyclin-dependent}} protein kinases regulate passage through the {{c1::cell cycle}}
Published	07/28/2024	{{c1::multiple}} cyclin and Cdk complexes regulate cell-cycle control and more specifically
Published	07/28/2024	Growth factors and nutrients (like amino acids) can lead to the activation of {{c1::TOR}} via activation of {{c1::Akt}} which leads to protein synthes…
Published	07/28/2024	Mutations affecting cell cycle regulatory proteins frequently cause what and what is a common target for therapy?
Published	07/28/2024	How is the the cell cycle manipulated in cancer therapy?
Published	07/28/2024	Overview of cell cycle
Status	Last Update	Fields