Notes in 01a Peripheral Nervous System Dysfunction

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Published	05/13/2024	{{c2::Distal}} to a site of CNS or PNS axon injury there is {{c1::anterograde (Wallerian)}} degeneration
Published	05/13/2024	{{c2::Proximal}} to a site of CNS or PNS axon injury there is {{c1::retrograde}} degeneration
Published	05/13/2024	In response to axon damage, the neuron cell body undergoes {{c1::Axonal reaction}}, which is the swelling of the cell body and dispersion of Nissl sub…
Published	05/13/2024	Axons that are myelinated by {{c1::Schwann cells}} have the potential to regenerate following injury
Published	05/13/2024	Which nervous system cell is typically damaged by Guillain-Barré syndrome? {{c1::Schwann cells}}
Published	05/13/2024	Changes associated with chromatolysis reflect increased {{c1::protein}} synthesis in effort to repair the damaged axon
Published	05/13/2024	Chromatolysis is characterized by displacement of the {{c1::nucleus}} to the periphery
Published	05/13/2024	Chromatolysis is characterized by dispersion of {{c1::Nissl substance}} throughout the cytoplasm
Published	05/13/2024	Chromatolysis is concurrent with {{c1::Wallerian}} degeneration
Published	05/13/2024	Acute inflammatory demyelinating polyradiculopathy is the most common subtype of {{c1::Guillain-Barré}} syndrome
Published	05/13/2024	Guillain-Barré syndrome is a(n) {{c1::autoimmune}} condition that destroys {{c2::Schwann}} cells
Published	05/13/2024	{{c2::Guillain-Barré}} syndrome results in symmetric {{c1::ascending::ascending or descending}} muscle weakness/paralysis
Published	05/13/2024	Guillain-Barré syndrome is associated with {{c1::increased}} CSF protein and {{c2::normal}} cell count, which may cause papilledema
Published	05/13/2024	In addition to respiratory support, Guillain-Barré syndrome may be treated with {{c1::plasmapheresis}} and IV {{c2::immunoglobulins}}
Published	05/13/2024	Are steroids useful in the management of Guillain-Barré syndrome? {{c1::No}}
Published	05/13/2024	What structural foot abnormalities are associated with Charcot-Marie-Tooth disease? {{c1::Pes cavus}} and {{c2::hammer toes}}
Published	05/13/2024	Charcot-Marie-Tooth disease may present with lower extremity weakness (e.g. {{c1::foot drop}}) and sensory deficits
Published	05/13/2024	Charcot-Marie-Tooth disease is a group of nerve disorders caused by defective production of proteins involved in the structure and function of {{c1::p…
Published	05/13/2024	Guillain-Barré syndrome results in {{c1::inflammation}} and segmental {{c2::demyelination}} of peripheral nerves and motor fibers
Published	05/13/2024	Taxanes can cause a peripheral sensory neuropathy as well as induce {{c2::hypersensitivity}} reactions
Published	05/13/2024	Carpal tunnel syndrome is due to entrapment of the {{c2::median}} nerve between the {{c1::transverse carpal}} ligament and the {{c1::carpal}} bones
Published	05/13/2024	Nerve compression in carpal tunnel syndrome presents as {{c1::paresthesia}}, {{c2::pain}}, and {{c3::numbness}} in the distribution of the {{c4::media…
Published	05/13/2024	Isoniazid promotes the excretion of {{c1::pyridoxine (Vitamin B6)}}, therefore resulting in deficiency and peripheral neuropathy
Published	05/13/2024	Platinum analogs are known to cause {{c1::peripheral neuropathy}} in a stocking-glove distribution
Published	05/13/2024	Which of the platinum analogs is most commonly associated with peripheral neuropathy?{{c1::Cisplatin}}
Published	05/13/2024	Diabetic neuropathy strictly affects {{c1::lower::upper or lower}} motor neurons
Published	05/13/2024	CSF analysis in {{c1::Guillain-Barré}} syndrome will reveal {{c2::albuminocytologic}} dissociation
Published	05/13/2024	Patients with diabetic neuropathy present with a slowly progressive decrease in vibratory sensation, {{c1::proprioception}}, and {{c2::temperature}} s…
Published	05/13/2024	Patients with early diabetic neuropathy typically have decreased {{c1::ankle}} reflexes
Published	05/13/2024	Patients with late diabetic neuropathy have widespread loss of reflexes with motor {{c1::weakness}}
Published	05/13/2024	As opposed to acute disseminated encephalomyelitis, Guillain-Barré syndrome develops over the course of {{c1::days}} to {{c1::weeks}} once sympto…
Published	05/13/2024	Guillain-Barré = {{c1::ascending::ascending or descending}} paralysis/weakness and {{c1::hypo}}reflexia
Published	05/13/2024	Paresthesia and pain but sparing of the the sensation over the thenar eminence is suggestive of {{c1::Carpal Tunnel}} syndrome
Published	05/13/2024	A peripheral neuropathy affects {{c1::peripheral nerves::structure}}
Published	05/13/2024	Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) presents with symptoms similar to {{c1::Guillain-Barré syndrome::disease}}, thou…
Published	05/13/2024	What neurological side effect is associated with vincristine use?{{c1::Peripheral neuropathy}}
Published	05/13/2024	What neurological side effect is associated with isoniazid use?{{c1::Peripheral neuropathy}}
Published	05/13/2024	Diagnosis of Guillain–Barré syndrome is made by clinical findings, CSF analysis, and {{c1::nerve conduction}} studies
Published	05/13/2024	When PNS neuron is injured,1) {{c1::distal}} axon degenerates2) {{c1::macrophages}} clean up debris3) {{c1::Schwann cells}} guide axon as it regrows
Published	05/13/2024	In the PNS, each Schwann cell myelinates {{c1::one}} axon(s), and each axon is myelinated by {{c1::many}} Schwann cell(s)
Published	05/13/2024	{{c2::Guillain-Barre Syndrome}} is an autoimmune destruction of {{c1::PNS::CNS/PNS}} myelin and {{c1::Schwann cells::cell type}}
Published	05/13/2024	What type of neuropathy describes lesions of multiple individual peripheral nerves, usually in an asymmetric pattern?{{c1::Mononeuropathy multiplex}}
Published	05/13/2024	Does electromyography differentiate between axonal and demyelinating neuropathy?{{c1::No}}
Published	05/13/2024	Does nerve conduction velocity differentiate between axonal and demyelinating neuropathy?{{c1::Yes}}
Published	05/13/2024	{{c1::Axonal}} neuropathy presents with normal conduction velocity and reduced amplitude
Published	05/13/2024	{{c1::Demyelinating}} neuropathy presents with reduced conduction velocity and normal amplitude
Published	05/13/2024	The most common causes of axonal neuropathy are {{c1::toxic}} or {{c1::metabolic}}
Published	05/13/2024	Charcot Marie Tooth is a(n) {{c1::demyelinating::axonal or demyelinating}} neuropathy
Published	05/13/2024	The most common causes of demyelinating neuropathy are {{c1::Guillain-Barre syndrome}} or {{c1::Charcot-Marie-Tooth}}
Published	05/13/2024	Guillain-Barre Syndrome has two forms, AIDP, which is a(n) {{c1::demyelinating}} neuropathy, and AMAN, which is a(n) {{c1::axonal}} neuropat…
Published	05/13/2024	Guillain-Barre Syndrome mostly affects the {{c1::motor}} nerves, but it can also present with {{c1::sensory}} deficits
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