Notes in 03. Bioavailability

To Subscribe, use this Key

Status	Last Update	Fields
Published	10/21/2024	This involves specific carrier proteins that span the membrane and is capable of moving drugs against a concentration gradient.
Published	10/21/2024	Movement against a concetration gradient is a movement from a region of a. (high/low) drug concentration to one of b. (higher/lower) concentratio…
Published	10/21/2024	A characteristic of active transport driven by the hydrolysis of adenosine triphosphate (ATP).
Published	10/21/2024	Active transport is considered _______ because it relies on specific transporter proteins that have a limited capacity to bind and move molecules acro…
Published	10/21/2024	True or FalseActive transport is selective and may be competitively inhibited by other cotransported substances.
Published	10/21/2024	Used to transport drugs of exceptionally large sizes across the cellmembrane
Published	10/21/2024	Involves engulfment of a drug by the cell membrane and transport into the cell by pinching off a drug-filled vesicle
Published	10/21/2024	The reverse of endocytosis which is used by many cells to transfer substances out of the cell through a similar process of vesicle formation.
Published	10/21/2024	Figure 10. Mechanisms of Drug Permeation
Published	10/21/2024	Describe what happens in A
Published	10/21/2024	Identify what happens in Figure B.
Published	10/21/2024	Identify what occurs in Figure C.
Published	10/21/2024	Identify what occurs in figure D.
Published	10/21/2024	Enumerate the 5 factors influencing drug absorption
Published	10/21/2024	Factors influencing absorptionpHMost drugs are either weak acids or weak bases→ A drug passes through membranes (more or less) readily if it is unchar…
Published	10/21/2024	FACTORS INFLUENCING ABSORPTIONpHThe relative concentration of charged and uncharged forms of a drug determines effective concentration of the _______ …
Published	10/21/2024	The ratio between the permeable and non-permeable forms of a drug is determined by these two parameters. Name them.
Published	10/21/2024	This parameter is represented by the ionization constant, pKa.
Published	10/21/2024	Which factor influencing absorption is described below?Absorption from the intestine is favored over the stomach→ Intestines receive much more blood f…
Published	10/21/2024	Why is absorption from the intestine favored over the stomach?
Published	10/21/2024	Which factor influencing absorption is described below.This allows for more drug particles to come into contact with the absorbing membrane (such…
Published	10/21/2024	Why is the absorption of drug across the intestine more efficient?
Published	10/21/2024	How does blood flow and surface affect the rate of absorption?
Published	10/21/2024	Which factor influencing absorption is described below?Anything that delays the transport of the drug from the stomach tothe intestine delays the rate…
Published	10/21/2024	Effects of food presence in the stomach to drug absorption
Published	10/21/2024	What is the relationship between contact time and absorption rate?
Published	10/21/2024	A transmembrane transporter protein responsible for transportingvarious molecules across cell membranes.
Published	10/21/2024	How is P-glycoprotein involved in the transportation of drugs from tissue to blood?
Published	10/21/2024	Which factor influencing absorption is described below:→ Reduces drug absorption→ Associated with multidrug resistance
Published	10/21/2024	Determined by comparing {{c1::plasma levels }} of a drug after a particular {{c1:: route of administration }}Total {{c1::AUC }} reflects the extent of…
Published	10/21/2024	Why is the AUC (area under the curve) of orally administered medication lower than those that are introduced intravenously?
Published	10/21/2024	First-Pass Hepatic MetabolismA drug absorbed from the Gl tract enters the {{c1::portal }} circulation before entering the systemic circulationIf the d…
Published	10/21/2024	First-Pass Hepatic MetabolismFirst-pass metabolism by {{c1::the intestine or liver }} limits the efficacy of many {{c1:oral::sublingual / oral }} medi…
Published	10/21/2024	Drug SolubilityVery {{c1::hydrophilic }} drugs are {{c1:poorly::adequately / poorly}} absorbed because of the inability to cross {{c1:lipid-rich::lipi…
Published	10/21/2024	Chemical Instability{{c1::Penicillin G }} is {{c1:unstable::stable / unstable}} in the pH of gastric contents{{c1::Insulin }} is destroyed in the Gl t…
Published	10/21/2024	Nature of drug formationFactors that can influence the ease of dissolution and subsequently alter the rate of absorption
Status	Last Update	Fields