Notes in Virology 2

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Published	08/28/2024	An {{c1::antigenome}} is full length RNA with opposite {{c2::polarity}} of genomic RNAs.It is used to synthesize {{c2::progeny RNA}}
Published	08/28/2024	{{c1::Subgenomic RNAs}} have less genomic length than mRNAs and encode viral proteins
Published	08/28/2024	{{c1::Ambisense}} is a viral genome where mRNAs are produced from both {{c2::(-) strand}} genomic RNA and {{c2::(+) complementary}} strand
Published	08/28/2024	RNA virus face a few issues:They have a low {{c1::genetic capacity}} and RNA virus must enter the {{c1::nucleus}} to spliceRNA virus also wi…
Published	08/28/2024	Replication of RNA virus:typically occurs in the {{c1::cytoplasm}}is mediated by {{c1::viral specific RNA polymerases}}requires synthesis of…
Published	08/28/2024	RNA virus replication always requires {{c1::dsRNA}}, but formation of {{c2::specialized replication complexes}} is one way to hide from the immun…
Published	08/28/2024	RNA virus increase genetic capacity via different mechanisms:{{c1::segmented}} RNA genome{{c1::linear subgenomic}} RNA{{c1::polyprotein}} synthesis{{c…
Published	08/28/2024	{{c1::Polyproteins}} are cleaved into individual viral proteins using proteases
Published	08/28/2024	{{c1::Influenza A}} - Flu of 1918, and had 8 segmented genes capable of {{c1::reassortment}}, which caused recurrent pandemics
Published	08/28/2024	What do the H and N descriptors of the flu virus stand for?H: {{c1::Hemagglutinin}}N: {{c1::Neuraminidase}}
Published	08/28/2024	Most virus are limited to a single species, but some can be {{c1::zoonoses}}, meaning that they can be naturally transmitted interspecies{{c2::Ar…
Published	08/28/2024	Virus like Influenza A can make new strains by {{c1::mixing of two previous strains}}
Published	08/28/2024	SARS CoV2:Incubation time: {{c1::3}} daysSymptoms: {{c1::dry cough, ache, malaise, SOB, hemoptysis, etc.}}Signs of {{c1::pulmonary fibr…
Published	08/28/2024	{{c1::Nested mRNA}} has one main genome with the same leader (5') and ending (3') sequences, but start at different places allowing for enhanced genom…
Published	08/28/2024	Antithrombin may possible be used to treat {{c1::sepsis}}, but there is no clear treatment for it
Published	08/28/2024	Ebola virus is a filamentous {{c1::negative single-strand RNA virus::type of virus}}.Replicates via {{c1::endosome}} uptake of EBOV and replicati…
Published	08/28/2024	{{c1::Retrovirus}} are RNA virus that injects a copy of its RNA genome into the DNA, changing it.EX: {{c1::HIV}}
Published	08/28/2024	HIV will target {{c1::dendritic cells}}, {{c1::macrophases}}, {{c1::CD4+ T-cells}}Will display symptoms similiar to mono before lying d…
Published	08/28/2024	How does HIV mature?Protease cleaves {{c1::Gag}} and {{c1::Gag-Pol}} polyproteinsComponents rearrange to make the {{c1::Fullerene Cone …
Published	08/28/2024	HIV treatment typically consists of anti-retroviral therapy that targets {{c1::reverse transcription}}, {{c1::fusion inhibitors}} via NRTI /…
Published	08/28/2024	Reservours of HIV virus are typically immune cells, including:{{c1::CD4+}}, {{c1::macrophages}}, {{c1::microglial}}, {{c1::astrocytes}}…
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