Notes in Module 5 - Pharmacokinetics

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Published	01/07/2024	Pharmacokinetics originate from the words "pharmakon" (drug/poison) and "kinesis" (movement). What questions are answered by this discipline?
Published	01/07/2024	How is Kinetics different from dynamics?
Published	01/07/2024	What are the four main processes in pharmacokinetics?
Published	01/07/2024	What is elimination?
Published	01/07/2024	What is disposition?
Published	01/07/2024	What are the five major routes of administration?
Published	01/07/2024	It is the transport of unmetabolized drug from site of administration into the plasma or circulatory system (in most cases)
Published	01/07/2024	What are the three major modes of absorption?
Published	01/07/2024	How is aqueous diffusion different from lipid diffusion?
Published	01/07/2024	What two features are possible through carrier-mediated membrane transport?
Published	01/07/2024	What four factors affect the efficacy of absorption?
Published	01/07/2024	Ionized drugs are ___ while unionized drugs are ___
Published	01/07/2024	Weak acids are better absorbed in ___ pH environments
Published	01/07/2024	What are the ideal characteristics of a drug molecule for better absorption?
Published	01/07/2024	What are the four common patient factors that affect drug absorption?
Published	01/07/2024	Define distribution
Published	01/07/2024	How is distribution related to efficacy and toxicity?
Published	01/07/2024	What four factors affect drug distribution?
Published	01/07/2024	What are the ideal characteristics of a drug with high distribution that make it easier to reach the target?
Published	01/07/2024	It is the theoretical volume of fluid into which total drug administered would have to be diluted to produce the concentration in plasma
Published	01/07/2024	What is the formula for Volume of distribution?
Published	01/07/2024	Drugs that remain in blood have ___ Vd
Published	01/07/2024	Define metabolism
Published	01/07/2024	What are the two potential metabolic actions on a drug?
Published	01/07/2024	How are phases of metabolism classified?
Published	01/07/2024	Phase I Metabolism involves what processes?
Published	01/07/2024	What is special about Cytochrome p450 enzymes?
Published	01/07/2024	How are anti-epileptic and some TB medications metabolized?
Published	01/07/2024	What processes are Phase II Metabolism involved with?
Published	01/07/2024	What is special about glucuronidation?
Published	01/07/2024	What processes are involved with Phase III Metabolism?
Published	01/07/2024	Define excretion
Published	01/07/2024	Passive diffusion is utilized by drugs that treat opioid overdose. How?
Published	01/07/2024	Active tubular secretion is another type of excretion. What Phase of Metabolism does it primarily subserve?
Published	01/07/2024	It is the amount of drug removed from the body per unit time (mg/h)
Published	01/07/2024	It is the rate or flow of drug elimination of plasma volume per unit time (L/h)
Published	01/07/2024	What are the four pharmacokinetic properties?
Published	01/07/2024	It is the highest observed plasma drug concentration since administration of a single dose
Published	01/07/2024	It is the time at maximum concentration
Published	01/07/2024	It is the length of time before half the drug clears the body
Published	01/07/2024	It is a measure of drug exposure, usually computed by Trapezoidal Rule
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