Notes in 14 Antiarrhythmic Drugs

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Status	Last Update	Fields
Published	07/30/2024	Long QT syndrome is caused by {{c1::K+ blocking}} drugs
Published	07/30/2024	Delayed Afterdepolarization (DAD) is caused by {{c1::calcium overload}}:- {{c2::Digitalis excess (Digoxin Toxicity)}}- {{c2::Catecholam…
Published	07/30/2024	VAUGHAN-WILLIAMS CLASSIFICATION ClassBlocks...Effect Class I{{c1::sodium channel}}{{c1::Slow conduction velocity}}Clas…
Published	07/30/2024	VAUGHAN-WILLIAMS CLASSIFICATION ClassEffectDrugs 1AMarkedly slow conduction;Markedly prolonged AP duration{{c1::Disopy…
Published	07/30/2024	VAUGHAN-WILLIAMS CLASSIFICATION ClassEffectDrugs 2Blocks adrenergic receptors = blunt sympathetic effects{{c1::Beta-bl…
Published	07/30/2024	CLASS 1 ANTIARRHYTHMIC DRUGSRapid Binding: {{c1::Lidocaine::drug}}Slow Binding: {{c1::Flecainide::drug}}
Published	07/30/2024	Only Classes {{c1::IC, IA, and III}} of ANTIARRHYTHMIC DRUGS have {{c2::atrium}} and {{c2::ventricles}} as their site of activity
Published	07/30/2024	CLASS 1 ANTIARRHYTHMIC DRUGS{{c1::T:: T/F}}Do not bind tonically; constantly binding and unbinding from Na channel
Published	07/30/2024	CLASS 1 ANTIARRHYTHMIC DRUGS{{c1::Direct::Direct/Reverse}} use dependence Ideal for tx of {{c2::paroxysmal tachyarrhythmias}}
Published	07/30/2024	CLASS 1 ANTIARRHYTHMIC DRUGS{{c1::F:: T/F}}All class I drugs have pure sodium blocking capacity
Published	07/30/2024	CLASS 1 ANTIARRHYTHMIC DRUGSClass {{c1::IB}} drugs are ONLY capable of blocking Na channels.Class {{c1::IC}} drugs have good Na blocking capabilities …
Published	07/30/2024	Classes {{c1::IC, IA, and III}} terminate arrhythmia via {{c2::medical cardioversion}}
Published	07/30/2024	Location of Activity of antiarrythmic drugs:Atrium, ventricle: Class {{c1::IC, IA, III}}AV Node: Class {{c1::II, IV}}
Published	07/30/2024	Class {{c1::IC agents (Flecainide)}} confers increased risk for proarrythmia (Tendency to facilitate emergence of new arrhythmias)
Published	07/30/2024	PROARRHYTHMIA RELATIVE RISKIf you provide Class {{c1::III}} agents -> {{c1::K+}} Blocking -> Risk of {{c2::Torsades de Pointes}}If you provide C…
Published	07/30/2024	CLASS 1 ANTIARRHYTHMIC DRUGS{{c1::T::T/F}}Risk of Reentry Exacerbation is higher for Class IC compared to Class IB.
Published	07/30/2024	CLASS IA ANTIARRHYTHMIC DRUGS{{c1::QUINIDINE::Drug}}Blocks alpha adrenergic receptors and can cause peripheral vasodilation (especially IV)Vagolytic e…
Published	07/30/2024	CLASS IA ANTIARRHYTHMIC DRUGS{{c1::QUINIDINE::Drug}}THERAPEUTIC USE:{{c2::Moderately effective for atrial/ventricular tachyarrhythmiasShould not be us…
Published	07/30/2024	CLASS IA ANTIARRHYTHMIC DRUGS{{c1::QUINIDINE::Drug}}ADVERSE EFFECTS:Most COMMON side effect: {{c2::GI Disturbances (Diarrhea)}}Most IMPORTANT side eff…
Published	07/30/2024	CLASS IA ANTIARRHYTHMIC DRUGS{{c1::QUINIDINE::Drug}}DRUG INTERACTIONS:Increases {{c3::digoxin}} levelInhibits {{c3::cytochrome P450}} decreasing metab…
Published	07/30/2024	CLASS IB ANTIARRHYTHMIC DRUGS{{c1::T:: T/F}}Class IB drugs are those which have little effect on the QRS of normal heart at normal heart rates, and sl…
Published	07/30/2024	CLASS IB ANTIARRHYTHMIC DRUGSAction is only on the {{c1::ventricle}} therefore, it is only effective for {{c1::ventricular}} arrhythmias
Published	07/30/2024	CLASS IB ANTIARRHYTHMIC DRUGS{{c1::LIDOCAINE::Drug}}THERAPEUTIC USES:{{c2::Ventricular tachyarrhythmiasLittle effect on atrial tissue}}
Published	07/30/2024	CLASS IB ANTIARRHYTHMIC DRUGS{{c1::LIDOCAINE::Drug}}ADVERSE EFFECTS:{{c2::CNS side effectsRarely causes proarrhythmiaPropranolol, metoprolol, and cime…
Published	07/30/2024	CLASS IC ANTIARRHYTHMIC DRUGS{{c1::F::T/F}}Class IC drugs have a mild effect to prolong the QRS of normal heart at normal heart rates, with a large ef…
Published	07/30/2024	CLASS IC ANTIARRHYTHMIC DRUGS{{c1::FLECAINIDE::Drug}}Significant negative inotropic effect, similar to {{c2::disopyramide}}Negative inotropic effect: …
Published	07/30/2024	CLASS IC ANTIARRHYTHMIC DRUGS{{c1::FLECAINIDE::Drug}}THERAPEUTIC USES:{{c2::Effective on atrial and ventricular arrhythmiasTerminating and preventing …
Published	07/30/2024	CLASS III ANTIARRHYTHMIC DRUGS{{c1::SOTALOL::Drug}}MOA:{{c2::beta-adrenergic receptor blocking (class 2)action potential prolonging (class 3)}}
Published	07/30/2024	CLASS III ANTIARRHYTHMIC DRUGS{{c1::SOTALOL::Drug}}THERAPEUTIC USES:{{c2::life-threatening ventricular arrhythmiasmaintenance of sinus rhythm in patie…
Published	07/30/2024	CLASS III ANTIARRHYTHMIC DRUGS{{c1::SOTALOL::Drug}}ADVERSE EFFECTS:{{c2::Bradycardia, negative inotropy, asthma exacerbationTorsades de Pointes}}
Published	07/30/2024	CLASS III ANTIARRHYTHMIC DRUGS{{c1::AMIODARONE::Drug}}THERAPEUTIC USES:{{c2::maintaining Normal Sinus Rhythm (NSR) with atrial tachyarrhythmiasBypass …
Published	07/30/2024	CLASS III ANTIARRHYTHMIC DRUGS{{c1::AMIODARONE::Drug}}ADVERSE EFFECTS:{{c2::GastrointestinalPulmonary (ARDs, Chronic intersitial fibrosis)ThyroidCutan…
Published	07/30/2024	CLASS III ANTIARRHYTHMIC DRUGS{{c1::AMIODARONE::Drug}}DRUG INTERACTIONS:Increase levels: {{c3::Digoxin, quinidine, procainamide, phenytoin, flecainide…
Published	07/30/2024	CLASS III ANTIARRHYTHMIC DRUGS{{c1::DRONEDARONE::Drug}}Like amiodarone except that it has no iodine so it has no effect on the thyroid gland
Published	07/30/2024	CLASS III ANTIARRHYTHMIC DRUGS{{c1::DRONEDARONE::Drug}}THERAPEUTIC USES:{{c2::Only for Atrial Fibrillation}}
Published	07/30/2024	CLASS III ANTIARRHYTHMIC DRUGS{{c1::DRONEDARONE::Drug}}ADVERSE EFFECTS:{{c2::liver toxicity }}
Published	07/30/2024	CLASS III ANTIARRHYTHMIC DRUGS{{c1::DRONEDARONE::Drug}}DRUG INTERACTIONSDo not coadminister with potent inhibitors such as {{c2::azole, similar antifu…
Published	07/30/2024	CLASS III ANTIARRHYTHMIC DRUGS{{c1::VERNAKALANT::Drug}}THERAPEUTIC USES:{{c2::Indicated only for atrial arrhythmias but not for ventricular arrhythmia…
Published	07/30/2024	CLASS II ANTIARRHYTHMIC DRUGS (BETA-BLOCKERS)Antiarrhythmic effect due to:{{c1::Beta-adrenoceptor blocking effect + Direct membrane effects}}
Published	07/30/2024	CLASS II ANTIARRHYTHMIC DRUGS (BETA-BLOCKERS)DOC for {{c1::the prevention of arrhythmia in patients who had a myocardial infarction (Post-MI)}}
Published	07/30/2024	CLASS II ANTIARRHYTHMIC DRUGS (BETA-BLOCKERS){{c1::Esmolol::Drug}} short-acting, for intraoperative and other acute arrhythmias
Published	07/30/2024	CLASS IV ANTIARRHYTHMIC DRUGS (CALCIUM CHANNEL BLOCKERS){{c1::VERAPAMIL::Drug}}ADVERSE EFFECTS:{{c3::Constipation (usually), lassitude, nervousness, p…
Published	07/30/2024	CLASS IV ANTIARRHYTHMIC DRUGS (CALCIUM CHANNEL BLOCKERS){{c1::VERAPAMIL::Drug}}THERAPEUTIC USE:{{c2:: ★ Second line for supraventricular tachycar…
Published	07/30/2024	MISCELLANEOUS ANTIARRHYTHMIC DRUGS{{c1::AdenosineMagnesiumPotassium::Enumerate}}
Published	07/30/2024	MISCELLANEOUS ANTIARRHYTHMIC DRUGS{{c1::ADENOSINE::Drug}}MOA: Activation of an inward rectifier K + current and inhibition of calcium current: hy…
Published	07/30/2024	MISCELLANEOUS ANTIARRHYTHMIC DRUGS{{c1::ADENOSINE::Drug}}CLINICAL USE: ★ DOC for {{c2::supraventricular tachycardia that has normal blood pressur…
Published	07/30/2024	MISCELLANEOUS ANTIARRHYTHMIC DRUGS{{c1::ADENOSINE::Drug}}INTERACTIONS: - less effective: {{c2::Theophylline, Caffeine (Adenosine Receptor blocker…
Published	07/30/2024	MISCELLANEOUS ANTIARRHYTHMIC DRUGS{{c1::ADENOSINE::Drug}}TOXICITY: Short livedHigh grade AV blockFlushingAF may occurHeadache, hypotension, nause…
Published	07/30/2024	MISCELLANEOUS ANTIARRHYTHMIC DRUGS{{c1::MAGNESIUM::Drug}}CLINICAL USE:★ DOC for {{c2::Digitalis-induced arrhythmias}} if {{c3::hypomagnesemia is prese…
Published	07/30/2024	PRINCIPLES OF DRUG USEEndpoints in Atrial Fibrillation:{{c1::Cardioversion}} – for acute AFGive {{c2::CAD or Amiodarone}}
Published	07/30/2024	PRINCIPLES OF DRUG USEEndpoints in Atrial Fibrillation:{{c1::Rate control}} – for Chronic AFGive {{c2::Class II}}For Risk of thrombus formation in LA,…
Status	Last Update	Fields