Notes in MIM 30 Central tolerance

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Published	09/14/2024	Where does central tolerance occur for B & T cells?
Published	09/14/2024	When does central tolerance occur?
Published	09/14/2024	What are the mechanisms of central tolerance?
Published	09/14/2024	{{c1::Deletion}} of self-reactive lymphocytes (B cells and T cells) is a form of central tolerance High-affinity binding to self-antigen …
Published	09/14/2024	Generation of Treg cells Natural Treg cells develop in the {{c3::thymus}} from moderately high-affinity CD4+ SP thymocytes; these cells …
Published	09/14/2024	{{c1::Anergy}} induction in B cells is a form of central tolerance. {{c2::Low::low/high}}-affinity binding to self-antigen causes a state wher…
Published	09/14/2024	{{c1::Receptor}} editing in B cells is a form of central tolerance. If the BCR (B cell receptor) recognizes self-antigen, the developing B cel…
Published	09/14/2024	Central and peripheral tolerance in CD4+ T cells helps maintain B cell tolerance in the periphery due to the {{c1::T-dependant B cell}} response.
Published	09/14/2024	Where does peripheral tolerance occur?
Published	09/14/2024	When does peripheral tolerance occur?
Published	09/14/2024	What are the Mechanisms of Peripheral Tolerance?
Published	09/14/2024	Mechanisms of Peripheral Tolerance: Deletion of self-reactive lymphocytes: Lack of costimulation: Even if self-reactive T cells encounte…
Published	09/14/2024	Anergy induction: Lack of costimulation or engagement of inhibitory receptors (e.g., {{c1::CTLA-4}} binding to {{c1::CD80/CD86}} or…
Published	09/14/2024	Suppression by Treg cells for peripheral tolerance: {{c1::Natural}} Treg cells (from the thymus) and {{c1::inducible}} Treg cells (develo…
Published	09/14/2024	What is AIRE (Autoimmune Regulator)? what does it have to do with immune tolerance?
Published	09/14/2024	Mutations in {{c1::AIRE::transcription factor}} lead to Autoimmune Polyendocrine Syndrome Type 1 (APS-1).
Published	09/14/2024	What is Foxp3? what does it have to do with immunity?
Published	09/14/2024	Mutations of {{c1::Foxp3}} transcription factor result in IPEX syndrome. Symptoms include: {{c2::Immune dysregulation, Polyen…
Published	09/14/2024	What is CTLA 4 and what does it have to do with immunity?
Published	09/14/2024	What is PD-1 and how does it relate to immunity?
Published	09/14/2024	what is Fas95 (CD95) and how does it relate to immunity?
Published	09/14/2024	Treg Cells: Development and Suppression Mechanisms Development: {{c1::Natural}} Treg cells develop in the {{c2::thymus}} from CD4+ SP thymocyt…
Published	09/14/2024	Treg Cells: Development and Suppression Mechanisms Mechanisms of Suppression: {{c1::Cytokine}}-mediated suppression: Treg cells secrete I…
Published	09/14/2024	What is the phenotype expression of Treg Cells? Treg cells express high levels of {{c1::CD25 (IL-2Rα)}}, {{c1::Foxp3}}, and {{c1:CTLA-4.}}
Published	09/14/2024	{{c1::Checkpoint blockade}} therapies target inhibitory receptors like {{c2::CTLA-4}} and {{c2::PD-1}}, allowing T cells to remain acti…
Published	09/14/2024	What are some drug therapies for cancer treatment that utilize checkpoint blockade?{{c1::Anti-CTLA-4 (e.g., ipilimumab)}} and {{c2::ant…
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