Notes in 09. Fluoroquinolones and 10. Linezolid

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Status	Last Update	Fields
Published	10/21/2024	Fluoroquinolone drugs include:{{c1::Moxifloxacin}}{{c1::Levofloxacin}}
Published	10/21/2024	{{c1::Moxifloxacin}} is most active against M. tuberculosis in vitro
Published	10/21/2024	Second Line Drugs: Used against strains that are resistant to the {{c1::first line drugs}}
Published	10/21/2024	Dosing:→ Moxifloxacin {{c1::400 mg daily}}→ Levofloxacin {{c2::500-750 mg daily to 1000 mg if tolerated}}
Published	10/21/2024	Most common adverse effects of Fluoroquinolone:→ {{c1::Nausea}}→ {{c1::Vomiting}}→ {{c1::Diarrhea}}
Published	10/21/2024	Always check ECG when taking Levofloxacin due to a possible {{c1:: QT prolongation}}
Published	10/21/2024	{{c1::Moxifloxacin}} does not need renal dose adjustment
Published	10/21/2024	{{c1::Levofloxacin}} must be taken with Vitamin B6 due to side effect of {{c1::peripheral neuropathy}} and must be with renal adjustment
Published	10/21/2024	Other adverse effects of Fluoroquinolones:→ {{c1::Headache}}→ Skin→ {{c1:: Rash}}→ {{c1:: Abnormal LFTs (Liver Function Tests)}}→ QT prolongation→ …
Published	10/21/2024	Risk factors→ {{c1:: Age}}→ {{c1::Renal insufficiency}}→ {{c1::Concurrent steroid use}}
Published	10/21/2024	MOA of Linezolid:Inhibits protein synthesis by preventing formation of {{c1::ribosome complex that initiates protein synthesis}}
Published	10/21/2024	Linezolid has unique binding site on {{c1:: 23S ribosomal RNA}} of the 5s subunit
Published	10/21/2024	Inhibits M tuberculosis in vitro at conc of {{c1:: 4-8 mcg/mL}}
Published	10/21/2024	LinezolidDosage: {{c1:: 600 mg}} in adult and {{c1:: supplemental pyridoxine}} is recommended
Published	10/21/2024	LinezolidAdverse effectsPrincipal Toxicity: {{c1:: Hematologic}}
Published	10/21/2024	Adverse effects of linezolid in patients with predisposition to bone marrow suppression:{{c1:: Anemia}}{{c1::neutropenia}}
Published	10/21/2024	Adverse effects of linezolid in prolonged course{{c1::Optic and peripheral neuropathy}}{{c1:: Lactic Acidosis}}
Published	10/21/2024	Adverse effect of linezolid if given with SSRIs (Selective Serotonin Reuptake Inhibitors){{c1::Serotonin Syndrome}} (Mild: Fever chills)(Severe: Muscl…
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