Notes in L01 - What is Cancer

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Published	02/02/2025	What is cancer?What is a neoplasm?What is a beningn tumour?What is a malignant tumour?
Published	02/02/2025	Give 2 examples of tumours that originate from epithelial tissues.Give 4 examples of tumours that originate from non-epithelial tissues.
Published	02/02/2025	What is the microevolution process?What are driver mutations?
Published	02/02/2025	How do mutations arise?
Published	02/02/2025	What are monoclonal and polyclonal growths?Why may the monoclonal origin of a cancer be masked?
Published	02/02/2025	What are oncogenes?What does oncogene deregulation require?What are tumour supressor genes?What does tumour supressor gene deregulation require?
Published	02/02/2025	Cancer can originate from {{c1::any tissue}}Cancer is a {{c1::genetic}} disease driven by mutations in genes controlling {{c1::vital cellula…
Published	02/02/2025	What are the hallmarks of cancer?What do they help with?How many are there?
Published	02/02/2025	What is cancer hallmark 1?What are the three main ways cells achieve this?
Published	02/02/2025	What is hallmark 2 of a cancer cell?What is the cell cycle clock?What is pRb and how does it work?What does a loss of functional pRb lead to?
Published	02/02/2025	What is Hallmark 3 of a cancer cell?How is it achieved?What is a clinical side effect?
Published	02/02/2025	What is Hallmark 4 of a cancer cell?How is it achieved?
Published	02/02/2025	What is Hallmark 5 of a cancer cell?How is it achieved?
Published	02/02/2025	What is Hallmark 6 of cancer cells?How is this achieved?Describe EMT in further detail.
Published	02/02/2025	What is the metastatic process?
Published	02/02/2025	What is Hallmark 7 of a cancer cell?What are two ways this can be achieved?What are these switches linked to?
Published	02/02/2025	What is Hallmark 8 of cancer cells?How can this be achieved?
Published	02/02/2025	What are the enabling characteristics of cancer cells?
Published	02/02/2025	How do neoplastic cells interact with their microenvironment?What are the two types of life history microenvironments?
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