Notes in 07 Disorders of the Cerebellum

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Status	Last Update	Fields
Published	05/10/2024	Friedreich ataxia presents in {{c1::childhood::age group}} with {{c2::kyphoscoliosis::MSK}}
Published	05/10/2024	Do patients with cerebellar lesions sway with their eyes open or closed? {{c1::Both :)}}
Published	05/10/2024	{{c1::Dysdiadochokinesis}} is the impairment of performing rapid alternating movements and is associated with cerebellar dysfunction
Published	05/10/2024	{{c1::Ataxia}} is the incoordination of muscle movement
Published	05/10/2024	When getting a history of ataxia, it is important to {{c1::localize}} it and figure out the {{c1::timeframe}}
Published	05/10/2024	{{c1::Vascular}} causes of acute ataxia invole ischemic or hemorrhagic stroke
Published	05/10/2024	{{c1::Inflammatory}} causes of ataxia involve demyelinating disorders (MS) or cerebellitis
Published	05/10/2024	If you are dealing with {{c1::acute}} ataxia, you should be able to see some changes on MRI
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Published	05/10/2024	When dealing with Creutzfeldt-Jakob disease (CJD), you will see {{c1::cortical ribboning}} on MRI
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Published	05/10/2024	What is going on in the top 2 MRIs when compared to the bottom ones?{{c1::There is cerebellar atrophy}}
Published	05/13/2024	{{c1::Multiple system atrophy}} is the most common degenerative ataxia and is an alpha-synucleinopathy associated with REM behavior disorder and …
Published	05/10/2024	Red flag examination features that suggest {{c1::multiple system atrophy}} as the cause of ataxia include blue hands/feet, (+) Babinski reflex, head d…
Published	05/10/2024	What is happening in this MRI in a patient with chronic ataxia, and what's the diagnosis?{{c1::This is the "hot cross buns sign", suggestive of Multip…
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Published	05/10/2024	{{c1::Spinocerebellar}} ataxia is one of the largest categories of the autosomal dominant ataxias, with many of these conditions being triple-repeat e…
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Published	05/10/2024	The treatment for friedreich-ataxia is {{c1::omavelexone}} which works to improve {{c2::mitochondrial}} function and has antioxidant effects by t…
Published	05/10/2024	{{c1::Friedrich ataxia}} is weird because the patient has areflexia but a (+) babinski sign
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Published	05/10/2024	The {{c1::HINTS}} exam is when you cover an eye to see if it moves when you uncover it. If it does move then the eyes are misaligned, signal…
Published	05/13/2024	What is the mode of inheritance of Fragile X syndrome?{{c1::X-linked dominant}}
Published	05/13/2024	What class of diseases is Fragile X syndrome a part of?{{c1::Trinucleotide repeat expansion diseases}}
Published	05/13/2024	{{c2::Fragile X}} syndrome is due to a trinucleotide repeat in the {{c1::FMR1}} gene
Published	05/13/2024	What sequence of nucleotides is repeated in Fragile X syndrome?{{c1::CGG}}
Published	05/13/2024	What class of diseases is Friedreich ataxia a part of?{{c1::Trinucleotide repeat expansion diseases}}
Published	05/13/2024	What sequence of nucleotides is repeated in Friedreich ataxia?{{c1::GAA}}
Published	05/13/2024	{{c1::Friedreich ataxia}} is a trinucleotide repeat disorder that causes degeneration of the cerebellum and multiple spinal cord tracts
Published	05/13/2024	What is the mode of inheritance of Friedreich ataxia? {{c1::Autosomal recessive}}
Published	05/13/2024	Friedreich ataxia is caused by a mutated {{c1::frataxin}} gene on chromosome {{c2::9}}
Published	05/13/2024	The frataxin gene is essential for {{c1::mitochondrial}} {{c2::iron}} regulation
Published	05/13/2024	Mutation of the frataxin gene in Friedreich ataxia leads to impairment of {{c1::mitochondrial}} function
Published	05/13/2024	Friedreich ataxia patients often have {{c1::pes cavus::foot type}} with hammer toes
Published	05/13/2024	What eye movement disorder may be present in patients with Friedreich ataxia? {{c1::Nystagmus}}
Published	05/13/2024	The hallmark of {{c2::cerebellar}} dysfunction is {{c1::intention}} tremor without paralysis or paresis
Published	05/13/2024	Which movement disorder presents as a slow, zigzag motion when pointing/extending toward a target? {{c1::Intention tremor}}
Published	05/13/2024	Patients with lateral cerebellar lesions have propensity to fall {{c1::toward}} the lesioned side
Published	05/13/2024	One sign of lateral cerebellar lesion is {{c1::dysmetria}}, which is the inability to stop a movement at the proper place (e.g. finger to nose)
Published	05/13/2024	One sign of lateral cerebellar lesion is {{c1::dysdiadochokinesia}}, which is the reduced ability to perform alternating movements quickly (e.g. prona…
Published	05/13/2024	One sign of cerebellar lesions is {{c1::scanning dysarthria}}, in which patients divide words into syllables
Published	05/13/2024	One sign of lateral cerebellar lesion is {{c1::gaze}} dysfunction when the eyes try to fix on a point
Published	05/13/2024	Lesions of the {{c2::posterior}} cerebellar vermis usually result from medulloblastomas or ependymomas and present with {{c1::truncal}} ataxia
Published	05/13/2024	Do patients with dorsal column lesions sway with their eyes open or closed? {{c1::Closed (Romberg sign)}}
Published	05/13/2024	Ataxia-TelangiectasiA presents with a triad of:- {{c1::cerebellar defects (Ataxia)}}- {{c2::spider angiomas (Telangiectasia)}}- {{c3::IgA deficiency}}…
Published	05/13/2024	What is the most common cause of spontaneous lobar (parietal/occipital) hemorrhage in the elderly?{{c1::Cerebral amyl…
Published	05/13/2024	{{c1::Friedreich ataxia}} is a trinucleotide repeat disorder that can cause degeneration of the lateral corticospinal tract, spinocerebellar trac…
Published	05/13/2024	Friedreich ataxia may present with {{c1::diabetes::endocrine disorder}}
Published	05/13/2024	Anticipation is a frequent finding in {{c1::trinucleotide repeat expansion::group of}} disorders
Status	Last Update	Fields