Notes in 04_Polypharmacy and Aging Pharmacology

To Subscribe, use this Key

Status	Last Update	Fields
Published	02/10/2024	Polypharmacy describes the idea of {{c1::taking many medications}}, usually this happens as patients age and present with multiple acute and chronic c…
Published	02/10/2024	The risk of {{c1::adverse drug reactions (ADRs)}} increases as you increase the number of drugs that a patient is taking
Published	02/10/2024	Results of Medication-related problems (ADRs) in older patients {{c1::Falls}} {{c1::Cognitive loss}} {{c1::Dehydration}} {{c1::Incontinence}} {{c1::De…
Published	02/10/2024	The Concept of {{c2::Prescribing Cascade}} means that the {{c1::adverse drug events from a medication are interpreted as a new medical condition …
Published	02/10/2024	Four Stages of Pharmacokinetics (ADME)[1] {{c1::Absorption}}[2] {{c1::Distribution}}[3] {{c1::Metabolism}}[4] {{c1::Excretion}}
Published	02/10/2024	Changes to Absorption Pharmacokinetics in Older Patients:[1] {{c1::Changes in Rate of absorption}}[2] {{c1::May lead to delay in onset of drug effect}…
Published	02/10/2024	Due to an increase in {{c1::fat}}, and a decrease in {{c1::muscle}} and {{c1::body water}} in Older patients, there is an increase in {{c2::half life}…
Published	02/10/2024	Due to a decrease of {{c1::Albumin}} levels in Older patients, there is an increase in {{c2::serum levels}} of acidic drugs
Published	02/10/2024	In Older patients, there is an increase in the {{c1::permeability}} across the blood brain barrier, which affects the distribution of drugs
Published	02/10/2024	In Older patients, {{c1::Hepatic metabolism}} is less efficient due to a decrease in {{c2::liver mass}} and {{c2::liver blood flow}}
Published	02/10/2024	In Older patients, a decrease of Hepatic metabolism means that there is a:[1] Higher risk of {{c1::toxicity}} from drugs[2] Reduction of {{c1::fi…
Published	02/10/2024	In Older patients, {{c1::Renal Excretion}} is less efficient due to a reduction in {{c2::renal function}}
Published	02/10/2024	In Older patients, a decrease in Renal function means that there is a:[1] Higher risk of {{c1::toxicity}} from drugs[2] Reduction of {{c1::c…
Published	02/10/2024	As you age you become more sensitive to particular medicines; due to: {{c1::change in receptor binding}} {{c1::decrease in receptor number}} {{c1::alt…
Published	02/10/2024	When prescribing in the Aging Population, consider whether {{c1::drug}} therapy is the best therapeutic action
Published	02/10/2024	When prescribing in the Aging Population, start with {{c1::lower doses}} or {{c1::reduced frequency of administration}} of drugs
Published	02/10/2024	When prescribing in the Aging Population, think about the {{c1::side effects}} of a drug compared to its benefits (risk-benefit analysis)
Published	02/10/2024	Prescribing Tools and Guides for Polypharmacy Awareness and Optimization {{c1::Beers’ criteria}} {{c1::START-STOPP criteria}}
Published	02/10/2024	Deprescribing is a {{c1::reduction, substitution, or discontinuation of a drug due to: Adverse drug reactions, Drug-drug interactions, Drug-disease i…
Published	02/10/2024	Conclusion of a systematic review of medication withdrawal trials showed that:There is some evidence that it is safe and/or beneficial to stop {{c1::a…
Published	02/10/2024	Two Medications that cause the Most ADRs are {{c1::Anticholinergics}} and {{c1::Sedatives}}
Published	02/10/2024	Most Common Adverse Effects associated with NSAIDs are {{c1::Renal impairment}} and {{c1::GI Bleeding}}
Status	Last Update	Fields