Notes in Week 3 - Movement Disorders

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Status	Last Update	Fields
Published	08/17/2024	What type of basal ganglia connection is the following?{{c1::Normal :)}}
Published	08/17/2024	What type of basal ganglia connection is the following?{{c1::Parkinson's disease}}
Published	08/17/2024	What type of basal ganglia connection is the following?{{c1::Huntington's disease}}
Published	08/17/2024	{{c1::Parkinson's disease}} is characterized by loss of {{c2::dopaminergic}} neurons in {{c3::substantia nigra pars compacta}}
Published	08/30/2024	{{c1::Parkinson's}} disease is likely associated with the genes that code for {{c2::alpha-synuclein}}, {{c3::Parkin}}, and {{c4::LRRK2}}, and environm…
Published	08/30/2024	Which drugs can induce Parkinsonism?{{c1::Reserpine}}, {{c2::tetrabenazine}}, {{c3::antipsychotics}}, and {{c4::MPTP}}
Published	08/17/2024	Which drug that can induce Parkinsonism destroys dopaminergic neurons?{{c1::MPTP}}
Published	08/17/2024	What is a dopamine prodrug for Parkinson's Disease?{{c1::Levodopa}}
Published	08/17/2024	What drug class for Parkinson's disease binds to dopamine receptors and mimics the action of dopamine?{{c1::Direct-acting dopamine agonists}}
Published	08/17/2024	What is the name of a drug for Parkinson's disease inhibits dopa decarboxylase?{{c1::Carbidopa}}
Published	08/17/2024	What drug class for Parkinson's disease inhibits Catechol-o-methyltransferase?{{c1::COMT inhibitors}}What do they end with?{{c2::-capone}}
Published	08/30/2024	Which drug class for Parkinson's disease has central activity as anticholingeric agents?{{c1::Muscarinic antagonists}}
Published	08/30/2024	What drug class for Parkinson's disease inihibits adenosine?{{c1::Adenosine A2A inhibitors}} like {{c2::Istradefylline}}
Published	08/17/2024	Does dopamine cross the BBB?{{c1::No}}
Published	08/17/2024	Does Levodopa cross the BBB?{{c1::Yes}}
Published	08/17/2024	How is Levodopa converted to dopamine?{{c1::Decarboxylation}}
Published	08/17/2024	What is the historic gold standard for Parkinson's disease?{{c1::Levodopa}}
Published	08/17/2024	Can amino acids intefere with Levodopa transport across BBB?{{c1::Yes}}
Published	08/17/2024	What percent of Levodopa crosses the BBB?{{c1::1-3%}}
Published	08/30/2024	What are the metabolites of Levodopa?{{c1::HVA and DOPAC::2}}
Published	08/17/2024	How much of Levodopa appears in the urine as metabolites?{{c1::2/3}}
Published	08/17/2024	Can L-dopa wear off?{{c1::Yes}}
Published	08/30/2024	What is an issue with L-dopa?{{c1::Supersensitivity}}
Published	08/17/2024	What drug inhibits dopa decarboxylase?{{c1::Carbidopa}}
Published	08/17/2024	Does Carbidopa pass the BBB?{{c1::No}}
Published	08/17/2024	How much can Carbidopa reduce the daily dose of L-dopa by?{{c1::75%}}
Published	08/17/2024	What is the name of a combination of L-dopa and carbidopa?{{c1::Rytary}}
Published	08/17/2024	What should you avoid with L-dopa?{{c1::Anti-emetics b/c GI upset}}
Published	08/30/2024	What systems are affected by L-dopa?{{c1::GI, CV, and CNS (dyskinesias)::3}}
Published	08/17/2024	When is dyskinesias the worst (as a L-dopa adverse effect)?{{c1::At peak plasma}}
Published	08/30/2024	Why should you withdraw L-dopa slowly?{{c1::Avoid severe akinesia}}
Published	08/30/2024	What can happen if you give a MAO-inhibitor with L-dopa?{{c1::Hypertensive crisis}}
Published	08/30/2024	What are the contraindications for L-dopa?{{c1::Psychosis, angle closure glaucoma, and active peptic ulcers::3}}
Published	08/17/2024	Can dopamine agonists cross the BBB?{{c1::Yes, even without competing with amino acids}}
Published	08/30/2024	Which drug for Parkinson's disease is also commonly used to treat hyperprolactinemia?{{c1::Dopamine agonists (Bromocriptine)}}
Published	08/17/2024	What are adverse effects in ergot derivatives (dopamine agonists) that isn't the same as L-dopa?{{c1::Erythromelalgia}}, {{c2::vasospasm}}, and {{c3::…
Published	08/30/2024	What drug class has the contraindications psychotic illness, MI history, peripheral artery disease, and peptic ulcers?{{c1::Ergot derivatives (Dopamin…
Published	08/30/2024	What is used as monotherapy for mild parkinsonism?{{c1::Pramipexole}}
Published	08/30/2024	What can reduce required L-dopa dose and smooth response fluctuations?{{c1::Pramipexole}}
Published	08/17/2024	Are ergoline-induced adverse effects likely for Parmipexole and Ropinirole?{{c1::No}}
Published	08/17/2024	What is basically the same as Pramipexole?{{c1::Ropinirole}}
Published	08/30/2024	What can be used as temporary relief of off-period akinesia?{{c1::Apomorphine}}
Published	08/17/2024	How would you administer Apomorphine?{{c1::Subcutaneous}}
Published	08/30/2024	What is the onset of Apomorphine?{{c1::~10 minutes (duration is 2 hours)}}
Published	08/17/2024	Apomorphine can cause {{c1::nausea}}
Published	08/17/2024	MAO-{{c1::B::A or B}} only metabolizes dopamine
Published	08/17/2024	Which COMT inhibitor is both central and peripheral inhibitor?{{c1::Tolcapone}}
Published	08/30/2024	Which COMT inhibitor is only peripheral inhibitor only?{{c1::Entacapone}}
Published	08/30/2024	A {{c1::decrease}} in peripheral dopa decarboxylase will cause a compensatory {{c2::increase}} in COMT
Published	08/17/2024	Tolcapone and Entacapone have a half life of {{c1::2 hours}} and {{c2::Tolcapone}} has a longer duration
Published	08/17/2024	What Parkinson drug gives you orange urine?{{c1::COMT inhibitors}}
Published	08/17/2024	Tolcapone may be {{c1::hepato}}-toxic
Published	08/30/2024	What drug is for the treatment of tardive dyskinesia?{{c1::Valbenazine (VMAT2 inhibitor)}}
Published	08/30/2024	What drugs can exacerbate the chorea in Huntington's disease?{{c1::Dopmine-like drugs}}
Published	08/30/2024	What do you give for ALS?{{c1::Riluzole}}
Published	08/30/2024	What is a free radical scavenger for ALS?{{c1::Edaravone}}
Published	08/30/2024	What drug is the most effective for Tourette's Syndrome?{{c1::Haloperidol}}
Status	Last Update	Fields