Notes in I&D Asynch Nov 6 Adaptive Immunity

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Status	Last Update	Fields
Published	11/16/2023	Naïve T & B lymphocytes recirculate through peripheral lymphoid tissue in search for their ________
Published	11/16/2023	Previously naïve T & B cells mature into _____ cells to elicit a highly specific adaptive immune response
Published	11/16/2023	What two cell types are both innate and adaptive?
Published	11/16/2023	What is used to present antigen to CD8 T cells?
Published	11/16/2023	What is used to present antigen to CD4 T cells?
Published	11/16/2023	B cell receptors can recognize various ________ like protein, lipids, and glycolipids. T cell receptors can recognize only ____________ of protein ant…
Published	11/16/2023	What are the MHCs involved in doing?
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Published	11/16/2023	Describe VDJ recombination and its purpose...
Published	11/16/2023	What portion of a secreted antibody(Ex: IgG) defines the class of antibody?
Published	11/16/2023	What is an epitope?
Published	11/16/2023	Each epitope interacts with a different B cell Ag receptor, _________ immune responses.
Published	11/16/2023	Name that Isotype!• Peaks in 7-10 days• In blood• First antibody class to be secreted• Good for activating complement and agglutinating pathogens&nbsp…
Published	11/16/2023	Name that Isotype!• Highest concentration in blood• Peaks in 2.5 – 3 wks• Can diffuse into extravascular sites, can cross placenta • Great for: Comple…
Published	11/16/2023	Name that Isotype!• Predominantly in a membrane-bound form on mature B cells • Acts as B Cell Receptors in the initial Ag-triggering of B cells&n…
Published	11/16/2023	Name that Isotype!• Binds to receptors on mast cells and activates cells to cause histamine release when antigen binds • Great for: Response to p…
Published	11/16/2023	Name that Isotype!• Can cross epithelium; Passive immunity <--- breast milk• Main antibody secreted onto mucosal surfaces - Tears, saliva, mucus, c…
Published	11/16/2023	Affinity vs avidity
Published	11/16/2023	Act as central component of B cell receptors (BCR) Neutralization (or blocking) of pathogens and toxins *Mediate responses to antigen by Fc Receptor…
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Published	11/16/2023	_________________ = Direct crosslinking of BCR & Ag; No memory B cells; Mostly IgM
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Published	11/16/2023	Describe Opsonization: Fc-Dependent Phagocytosis
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Published	11/16/2023	CD8+ T cells are also known as _________ T cells.
Published	11/16/2023	CD4+ T cells are also known as _________ T cells.
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Published	11/16/2023	PAMPs _____ PRRs which cause the DC to secrete _______
Published	11/16/2023	What is the alloimmune response?
Published	11/16/2023	This disease is caused by a donor tissue not correctly matching the host tissue's HLA. The donor T cells attack the host tissue causing this condition…
Published	11/16/2023	A way to bypass peptide specificity to activate T cells is a concept called what?
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Published	11/16/2023	A massive release of TNFa is called....
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