Notes in DILLI

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Published 09/08/2024 Cirrhosis is chronic liver damage marked by the {{c1::degeneration}} of {{c1::cells}}, {{c1::inflammation}}, and {{c2::f…
Published 09/08/2024 Common causes of cirrhosis are (5) {{c1::alcoholism, viral hepatitis, nonalcoholic fatty liver disease, bile duct disease, genetic disorders}}
Published 09/08/2024 {{c1::Drug induced liver injury}} is responsible for approximately 50% of cases of acute liver failure in the US (accounts for 10% of all cases o…
Published 09/08/2024 Mechanism and histological presentation are drug {{c1::specific}} of DILI 
Published 09/08/2024 Risk factors of DILI are (5) {{c1::age, alcohol consumption, genetics, malnutrition, female gender}}
Published 09/08/2024 Management of DILI: {{c1::withdrawal}} of offending agent{{c2::Corticosteroids/antihistamines}} if immune mediated (limited evidence, not often u…
Published 09/08/2024 Prognosis of DILI: most will {{c1::fully recover}}
Published 09/08/2024  poor prognosis of DILI if development of {{c1::jaundice}} with ALT > {{c2::3x ULN}}, acute {{c3::liver failure}} d/t antiepile…
Published 09/08/2024 Acetaminophen (APAP, tylenol) Toxicity: Undergoes {{c1::glucuronidation}} and {{c1::sulfation}} into {{c1::non toxic}}&n…
Published 09/08/2024 {{c1::N-acetylcysteine (NAC)}} replenishes {{c2::glutathione}} stores to form {{c3::non-toxic metabolites}} in APAP toxicityDose duration: continue if…
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