Notes in DILLI

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Status	Last Update	Fields
Published	09/08/2024	Cirrhosis is chronic liver damage marked by the {{c1::degeneration}} of {{c1::cells}}, {{c1::inflammation}}, and {{c2::f…
Published	09/08/2024	Common causes of cirrhosis are (5) {{c1::alcoholism, viral hepatitis, nonalcoholic fatty liver disease, bile duct disease, genetic disorders}}
Published	09/08/2024	{{c1::Drug induced liver injury}} is responsible for approximately 50% of cases of acute liver failure in the US (accounts for 10% of all cases o…
Published	09/08/2024	Mechanism and histological presentation are drug {{c1::specific}} of DILI
Published	09/08/2024	Risk factors of DILI are (5) {{c1::age, alcohol consumption, genetics, malnutrition, female gender}}
Published	09/08/2024	Management of DILI: {{c1::withdrawal}} of offending agent{{c2::Corticosteroids/antihistamines}} if immune mediated (limited evidence, not often u…
Published	09/08/2024	Prognosis of DILI: most will {{c1::fully recover}}
Published	09/08/2024	poor prognosis of DILI if development of {{c1::jaundice}} with ALT > {{c2::3x ULN}}, acute {{c3::liver failure}} d/t antiepile…
Published	09/08/2024	Acetaminophen (APAP, tylenol) Toxicity: Undergoes {{c1::glucuronidation}} and {{c1::sulfation}} into {{c1::non toxic}}&n…
Published	09/08/2024	{{c1::N-acetylcysteine (NAC)}} replenishes {{c2::glutathione}} stores to form {{c3::non-toxic metabolites}} in APAP toxicityDose duration: continue if…
Published	09/08/2024	Toxic doses of {{c5::Acetamoniphen}}:Adults: {{c1::7-15}} g (recommended daily max is {{c2::4}} g or {{c2::2}} g in hepatic dysfunction…
Published	09/08/2024	what stage of DILI is described by death, emergent liver transplant?{{c1::stage 5}}
Published	09/08/2024	what stage of DILI is described by encephalopathy, coagulation, coma, hypoglycemia, jaundice, renal failurelab values: elevated AST, ALT, PT, lactic a…
Published	09/08/2024	what stage of DILI is described as RUQ abdominal pain, jaundice, coagulopathy, hepatomegalylab values: elevated, AST, ALT, and PT {{c1::stage 2}}
Published	09/08/2024	what stage of DILI is described as anorexia, nausea, vomiting, diaphoresislab values: normal AST and ALT{{c1::stage 1}}
Published	09/08/2024	{{c2::Clavulanate (Clavulanic acid)}}: onset of injury about 3 weeks after initiation of therapy, unknown mechanism, typically {{c1::idiosyncratic/cho…
Published	09/08/2024	the two types of hepatoxicity are {{c1::intrinsic}} and {{c1::idiosyncratic}}
Published	09/08/2024	intrinsic hepatoxicity is dose-{{c1::dependent}}{{c1::common}}{{c1::short}} latency{{c1::predictable}}ex. {{c1::acetaminophen}}
Published	09/08/2024	idiosyncratic hepatoxicity is:dose-{{c1::independent}}{{c1::uncommon}}{{c1::long}} latency and {{c1::hard to identify}}{{c1::unpredictable}}ex. {…
Published	09/08/2024	{{c1::Cholestatic}}: elevated {{c2::ALP}} disproportionate to {{c2::AST/ALT}}, jaundice, priotive, elevated bilirubin
Published	09/08/2024	{{c1::Hepatocellular}}: {{c3::cytotoxic}}, extremely elevated {{c2::AST/ALT}} disproportionate to {{c2::ALP}}
Published	09/08/2024	Cholestatic is {{c1::less severe}} than hepatocellular
Published	09/08/2024	{{c1::Mixed:}}: elevated {{c2::AST/ALT}} and {{c2::ALP}}
Published	09/08/2024	{{c1::Tylenol}}: intrinsic hepatocellular
Published	09/08/2024	Clavulanate: {{c1::idiosyncratic cholestatic}}
Status	Last Update	Fields