Notes in ✧ TCA Cycle

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Published	01/14/2024	The {{c1::pyruvate dehydrogenase}} complex is a mitochondrial enzyme complex linking glycolysis and the TCA cycle
Published	01/14/2024	Pyruvate dehydrogenase requires five enzymes/cofactors: 1. {{c1::Thiamine pyrophosphate (B1)}}2. {{c2::Lipoic acid}}3. {{c3::Coenzyme A (B5, pantothen…
Published	01/14/2024	{{c1::Acetyl-CoA}} is combined with {{c2::oxaloacetate}} via the enzyme {{c3::citrate synthase}}, forming {{c4::citrate}}
Published	01/14/2024	Citrate synthase is regulated via negative feedback by {{c1::ATP}}
Published	01/14/2024	Citrate is converted into {{c2::isocitrate}} via the enzyme cis-Aconitase (Kreb's cycle)
Published	01/14/2024	Isocitrate is converted to {{c1::α-ketoglutarate}} via the enzyme {{c2::isocitrate dehydrogenase}}
Published	01/14/2024	Conversion of isocitrate into α-ketoglutarate releases a molecule of {{c1::CO2}} and {{c1::NADH}}
Published	01/14/2024	Isocitrate dehydrogenase is regulated via negative feedback by {{c1::ATP}} and {{c2::NADH}}
Published	01/14/2024	Isocitrate dehydrogenase is regulated via positive feedback by {{c1::ADP}}
Published	01/14/2024	What is the rate-limiting enzyme for the Krebs cycle (TCA cycle)? {{c1::Isocitrate dehydrogenase}}
Published	01/14/2024	α-ketoglutarate is converted to {{c1::succinyl CoA}} via the enzyme {{c2::α-ketoglutarate dehydrogenase}}
Published	01/14/2024	Conversion of α-ketoglutarate into succinyl CoA releases a molecule of {{c1::CO2}} and {{c1::NADH}}
Published	01/14/2024	α-ketoglutarate dehydrogenase is regulated via negative feedback by {{c1::succinyl-CoA}}, ATP, and NADH
Published	01/14/2024	Succinyl CoA is converted to {{c1::succinate}} via the enzyme succinyl CoA synthetase
Published	01/14/2024	Conversion of succinyl CoA into succinate produces a molecule of {{c1::GTP}}
Published	01/14/2024	Which step of the Krebs cycle directly produces a molecule of GTP?{{c1::Succinyl CoA --> Succinate}}
Published	01/14/2024	Fumarate is converted to {{c1::malate}} via the enzyme fumarase
Published	01/14/2024	Malate is converted to {{c1::oxaloacetate}} via the enzyme malate dehydrogenase
Published	01/14/2024	Conversion of malate into oxaloacetate produces a molecule of {{c1::NADH}}
Published	01/14/2024	Which Krebs cycle enzyme requires the same 5 cofactors as pyruvate dehydrogenase (TLCFN)? {{c1::α-ketoglutarate dehydrogenase}}
Published	01/14/2024	Where in the cell does the Krebs cycle take place?{{c1::Mitochondria}}
Published	01/14/2024	In total, the TCA cycle produces {{c1::3}} NADH per acetyl-CoA
Published	01/14/2024	In total, the TCA cycle produces {{c1::1}} FADH2 per acetyl-CoA
Published	01/14/2024	In total, the TCA cycle produces {{c1::1}} GTP per acetyl-CoA
Published	01/14/2024	After complete metabolism, what is the total amount of ATP (or GTP) produced from 1 round of the Krebs cycle? {{c1::10 ATP equivalents}}
Published	01/14/2024	Where in the cell does conversion of pyruvate -> oxaloacetate take place?{{c1::Mitochondria}}
Published	01/14/2024	Acetyl-CoA carboxylase is regulated via positive feedback by {{c1::insulin}} and {{c2::citrate}}
Published	01/14/2024	The first step of fatty acid synthesis is transport of {{c1::citrate}} from the mitochondria to the cytosol through its shuttle
Published	01/14/2024	In the liver, glutamate may transfer its NH3 to {{c1::oxaloacetate}}, forming {{c2::aspartate}} and {{c3::α-ketoglutarate}}
Published	01/14/2024	Thiamine pyrophosphate (B1) is a cofactor for the enzyme {{c1::α-ketoglutarate dehydrogenase}} (TCA cycle)
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