Notes in JEMManki Term 1 (AnkiCollab)::FOM::Week 4::Lecture::Pham CV

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Published	09/18/2023	Sympathetic preganglionic neurons release {{c1::acetylcholine}} onto {{c2::nicotinic receptors}} of the {{c1::post-ganglionic neuron}}
Published	09/18/2023	Sympathetic postganglionic neurons release {{c1::catecholamines}} onto {{c2::adrenergic receptors}} on the {{c1::target organ cell}}
Published	09/18/2023	{{c2::α-1}} receptors affect {{c1::walls of blood vessels, pupils, urinary retention, ejaculation}}
Published	09/18/2023	parasympathetic preganglionic neurons release {{c1::ACH}} onto {{c1::Nicotinic recptors}} on the postganglionic neuron
Published	09/18/2023	Parasympathetic postganglionic neurons release {{c1::ACH}} onto {{c1::muscarinic receptors}} of the target organ cell
Published	09/18/2023	Nicotinic receptors are {{c1::Ligand gated ion channels::type}} allowing flow of {{c1::K+ Na+::ions}} causing {{c1::cell depolarization}}
Published	09/18/2023	{{c2::M1, M3, or M5}} receptor are {{c1::GqPCR}} activating {{c1::PKC}}
Published	09/18/2023	{{c2::M1}} receptor is {{c1::GsPCR}} causing (process) {{c2:: ↑ adenylate cyclase -> ↑ cAMP -> ↑ PKA activity}}
Published	09/18/2023	{{c2::M2, M4 (M1)}} are {{c1::GiPCR}} causing {{c1:: ↓ adenylate cyclase -> ↓ Gs protein (inhibitory)}}
Published	09/18/2023	Types of Sympathetic Agonists {{c1::Direct, indirect-acting, mixed-acting agonists}}
Published	09/18/2023	Types of Sympathetic antagonists {{c1::presynaptic adrenergic, and postsynaptic adrenergic antagonists}}
Published	09/18/2023	Types of direct sympathetic agonists {{c1::α-1 agonist, β agonists}}
Published	09/18/2023	β agonists can be {{c1::selective}} or {{c1::non-selective ie β1 vs β2}}
Published	09/18/2023	presynaptic adrenergic antagonists: {{c1::central (α-2 agonist) vs peripheral }}
Published	09/18/2023	postsynaptic adrenergic antagonists {{c1::α-blocker or β-blocker}}
Published	09/18/2023	β-blockers can be {{c1::selective or non- selective}}
Published	09/18/2023	parasympathetic agonists {{c1::direct or indirect cholinomimetics}}
Published	09/18/2023	direct cholinomimetics {{c1::mimic ACH}}
Published	09/18/2023	indirect cholinomimetics {{c1::ACH-esterases}}
Published	09/18/2023	parasympathetic antagonists are {{c1::muscarinic antagonistss}}
Published	09/18/2023	Parasympathetic: DUMB HAVES {{c1::defecation}}
Published	09/18/2023	Parasympathetic: DUMB HAVES {{c1::urination}}
Published	09/18/2023	Parasympathetic: DUMB HAVES {{c1::muscle excitation}}
Published	09/18/2023	Parasympathetic: DUMB HAVES {{c1::bronchospasm}}
Published	09/18/2023	Parasympathetic: DUMB HAVES {{c1::HR slowing}}
Published	09/18/2023	Parasympathetic: DUMB HAVES {{c1::autonomic ganglia stimulation}}
Published	09/18/2023	Parasympathetic: DUMB HAVES {{c1::vasodilation}}
Published	09/18/2023	Parasympathetic: DUMB HAVES {{c1::eye miosis}}
Published	09/18/2023	Parasympathetic: DUMB HAVES {{c1::secretions ie lacrimal, salivary, GI glands, sweat}}
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