Notes in OG6.3 Gestational Trophoblastic Disease

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Published	10/04/2024	Gestational Trophoblastic Disease is more common in {{c1::asian::ethnicity}} women
Published	10/04/2024	A hydatidiform mole can go one of the following ways:- {{c1::Spontaneous regression }}- {{c1::Persistant Trophoblastic Disease }}-…
Published	10/04/2024	Normal Pregnancy, miscarriage and ectopic pregnancy can lead to {{c1::placental site trophoblast::type of gestational trophoblastic disease}} and…
Published	10/04/2024	Complete hydatidiform mole arises when {{c1::a sperm duplicates inside the ovum::definition}}.
Published	10/04/2024	Complete hydatidiform mole arises as {{c1::46XX::genotype}}
Published	10/04/2024	Complete hydatidiform mole {{c1::doesn't::does/doesn't}} form embryonic tissue.
Published	10/04/2024	Partial hydatidiform mole arises when {{c1::two sperm fuse with the ovum}}
Published	10/04/2024	Partial hydatidiform mole is {{c1::69 XXY/69 XXX/69 XYY::Genotypes (3)}}
Published	10/04/2024	A {{c1::complete}} hydatiform mole consists of an abnormal placenta with a mass of tissue with grape-like, swollen chorionic villi
Published	10/04/2024	Most common symptom of hydatidiform mole is {{c1::vaginal bleeding in the first trimester}}
Published	10/04/2024	{{c1::Snow storm}} appearance on ultrasound is characteristic of {{c2::hydatidiform mole}}
Published	10/04/2024	3 investigations after diagnosing hydatidiform mole:- {{c1::Baseline TFTs }}- {{c1::Chest x-ray to rule out metastases from chorio…
Published	10/04/2024	Definitive diagnosis of hydatidiform mole → {{c1::histological after removal}}
Published	10/04/2024	Hydatidiform mole suspected, best treatment → {{c1::suction evacuation under anaesthesia}}
Published	10/04/2024	Follow up for hydatidiform mole includes {{c1::weekly::frequency}} β-hCG measurements until {{c2::undetectable}}
Published	10/04/2024	If a patient's hCG level after hydatidiform mole is normal within {{c1::8 weeks}} of evacuation, follow up can be limited to {{c2::6 months}…
Published	10/04/2024	Patients can use {{c1::OCPs}} as contraception after hydatidiform mole once hCG is normal
Published	10/04/2024	Low risk persistent gestational trophoblastic disease is treated with {{c1::methotrexate }}
Published	10/04/2024	High risk persistent gestational trophoblastic disease is treated with {{c1::EMA-CO protocol }}
Published	10/04/2024	Treatment for persistent gestational trophoblastic disease is continued until {{c1::6 weeks after hCG levels have become undetectable}}
Published	10/04/2024	Check serum hCG {{c1::6}} and {{c1::10 }} weeks after normal pregnancy to make sure no molar pregnancy
Published	10/04/2024	Choriocarcinoma is a malignant tumour containing {{c1::syncytiotrophoblast}} and {{c1::cytotrophoblast }} cells
Published	10/04/2024	Most common precursor for choriocarcinoma is {{c1::hydatidiform mole}}
Published	10/04/2024	Patient with vaginal bleeding, abdominal and vaginal swelling, and dyspnea, hemoptysis and headaches 6 weeks after giving birth → {{c1::chor…
Published	10/04/2024	Low risk choriocarcinoma is defined as {{c1::small tumour mass}} and {{c1::no metastases }}
Published	10/04/2024	Low risk choriocarcinoma is treated with {{c1::methotrexate }}
Published	10/04/2024	Treatment for choriocarcinoma with methotrexate continues until {{c1::hCG is normal + 2 more cycles}}
Published	10/04/2024	High risk choriocarcinoma is defined as {{c1::large tumour mass}}, {{c1::very high hCG }}, {{c1::long interval between the anteced…
Published	10/04/2024	Baseline hCG < {{c1::40,000 IU/L}} is a marker of good prognosis in choriocarcinoma
Published	10/04/2024	Baseline hCG > {{c1::40,000 IU/L}} is a marker of bad prognosis in choriocarcinoma
Published	10/04/2024	{{c1::< 4 months}} since end of pregnancy is a marker of good prognosis in choriocarcinoma
Published	10/04/2024	{{c1::> 4 months}} since end of pregnancy is a marker of bad prognosis in choriocarcinoma
Published	10/04/2024	Antecedent pregnancy {{c1::not reaching::reaching/not reaching}} term is a marker of good prognosis in choriocarcinoma
Published	10/04/2024	Antecedent pregnancy {{c1::reaching::reaching/not reaching}} term is a marker of bad prognosis in choriocarcinoma
Published	10/04/2024	Patients with choriocarcinoma are adviced to avoid pregnancy for at least {{c1::1 year}} after treatment
Published	10/04/2024	Patient with treated choriocarcinoma and family complete → {{c1::hysterectomy}}
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