Notes in Blands

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Status	Last Update	Fields
Published	03/01/2025	Lidocaine MOA: Class {{c1::IB}}; Stabilizes {{c1::Na+}} channel {{c1::inactive}} formSmall effect on {{c1::Vmax}} at therapeutic doses and {{c1::fast}…
Published	03/01/2025	Lidocaine therapeutics:{{c1::Ventricular}} arrhythmias in emergency medicine, surgery, and ICU{{c1::Rapid}} kinetics ({{c1::amide}} linkage) allow pre…
Published	03/01/2025	Procainamide MOA: Class {{c1::IA}}; Stabilizes {{c1::Na+}} channel {{c1::inactive}} form, plus off-target {{c1::K+}} channel inhibition{{c1::Prolongat…
Published	03/01/2025	Dofetilide MOA: Class {{c1::III}}; {{c1::KV11.1, IKr)}} channel inhibitor
Published	03/01/2025	Amiodarone MOA: Class {{c1::III}}; High-affinity {{c1::Kv}} channels inhibitor{{c1::Prolonged}} action potential duration and effective refractory per…
Published	03/01/2025	Amiodarone adverse effects:{{c1::Long QT}} Syndrome{{c1::After-depolarizations}}{{c1::Hypotension}} (vasodilation + bradycardia){{c1::Pulmonary fibros…
Published	03/01/2025	Sotalol MOA: Class {{c1::III}}; {{c1::KV}} channel and {{c1::β1}} inhibitor.↑ {{c1::action potential duration}} and {{c1::effective refractory period}…
Published	03/01/2025	Sotalol therapeutics:{{c1::Ventricular and supraventricular::2}} tachyarrhythmias, espically {{c1::paroxysmal}} and {{c1::re-entrant or accessory::2}}…
Published	03/01/2025	Metoprolol MOA: Class {{c1::II}}; {{c1::β1-AdR antagonist}}SA node and Purkinje fibers: ↓ {{c1::automaticity}}AV node: ↓ {{c1::conduction}}/ ↑{{c1::ef…
Published	03/01/2025	Metoprolol therapeutics:{{c1::Supraventricular}} tachycardia{{c1::Atrial}} fibrillation → slows {{c1::ventricular}} rate but does not convert to {{c1:…
Published	03/01/2025	Verapamil / Diltiazem adverse effects:{{c1::Bradycardia}}{{c1::Hypotension}} with vasodilator or β-blocker co-administrationContraindicated for patien…
Status	Last Update	Fields