Notes in 01. Clinical concepts in infectious diseases

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Status	Last Update	Fields
Published	06/26/2023
Published	06/26/2023
Published	06/26/2023	Defintions and concepts Pathogenicity → the ability of an {{c1::organism}} to cause disease Pathogenesis → the mechanism process of dev…
Published	06/26/2023	defintions reservoir → any living host, person, animal, arthropod, plant or envrionment in which a pathogen can be permanetly maintained and from…
Published	06/26/2023	spillover Bats comprise 20% of classified animal species common reservoir for numerous {{c1::viruses}} that can spillover
Published	06/26/2023	bat virus diveristy MC bat virus → {{c1::coronaviridae}}
Published	06/26/2023	transmission → mechanism by which an infectious agent spreads to or among humans contact → direct and indirect direct contact infected&…
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Published	06/26/2023	gram positive bacteria
Published	06/26/2023	gram negative bacteria
Published	06/26/2023	Virology → genetics overview Viruses contain either a {{c1::DNA}} or {{c1::RNA}} genome The virus usually hijacks some or all of t…
Published	06/26/2023	Virology → viral genetics dsDNA → utilize {{c1::their own}} viral DNA polymerase or host DNA polymerase to replicate ssDNA → form a {{c…
Published	06/26/2023	RNA vs DNA viruses RNA viruses have {{c1::higher}} mutation rates viral RNA polymerases lack the {{c1::proofreading}} ability of DNA po…
Published	06/26/2023	DNA viruses
Published	06/26/2023	RNA viruses
Published	06/26/2023
Published	06/26/2023	Naked vs Enveloped Viruses Naked lysis of cells upon {{c1::virons existing host cell}}Often causes {{c1::acute infections}}{{c1::m…
Published	06/26/2023	Enveloped viruses advantages exiting from host cell {{c1::without}} killing can {{c1::prevent}} immune system response Envelo…
Published	06/26/2023	genetic patterns of infection
Published	06/26/2023	factors affecting treatment{{c1::prokaryotic vs Eukaryotic}} Parasitic infections, intracellular pathogens, prions Viral infections DNA…
Published	06/26/2023	Gram Positive → {{c1::skin}} infection, {{c1::respiratory}} infection Gram negative → {{c2::pseudomonal}} infection, and {{c2…
Published	06/26/2023	Multi-drug resistant organisms (MDROs) Methicillin Resistant Staph Aureus Vancomycin resistant Staph Aureus Vancomycin Intermediate {Re…
Published	06/26/2023	Mechanisms of bacterial resistance Beta Lactamases A, B, C, DGram (-) bacilli produce {{c1::more broad}} spectrum beta lactamases than …
Published	06/26/2023	Mechanisms of Resistance Esterases{{c1::Hydrolyze}} lactone ring of erythromycin → E. coli Porin Mutations In gram negative bacteria De…
Published	06/26/2023	Mechanisms of Bacterial Resistance Efflux pumps Enteric Gram (-) bacteria Resistance to {{c1::tetracyclines, macrolides}}, aminogl…
Published	06/26/2023	Dr. Douglas emphasized HPI is 80-90% of importance PE is 10-20%
Published	06/26/2023	DDxfactors possibly indicating an infectious disease Clinical Hx travel, pets, occupation known exposure time from potential expos…
Published	06/26/2023
Published	06/26/2023
Published	06/26/2023
Published	06/26/2023
Status	Last Update	Fields