Notes in Cell Death, Inflammation, Repair

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Published	09/05/2023	{{c1::Wound healing}} is the process where body repairs damaged tissue after any traumatic injuries   → {{c2::acute}} wounds heal up quickly over…
Published	09/05/2023	Some tissues regenerate more easily than others*{{c1::regenerative capacity}} of tissue is classified as labile, stable, and permanent - {{c2::la…
Published	09/05/2023	Skinoften the most visible tissue that’s damagedwound healing occurs by primary, secondary, and tertiary intention - healing by {{c1::primary}}…
Published	09/05/2023	steps of would healing - {{c3::Penetrating}} injury: skin is punctured through the top two layers of skin ({{c1::epidermis}} and {{c2::dermis}}) …
Published	09/05/2023	Factors that prevent proper healing → leads to {{c1::chronic}} wounds - capillaries become narrowed by some disease → {{c2::blood flow}} decrease…
Published	09/08/2023	Cells have two ways to die:- {{c1::apoptosis}}: programmed cell death (physiologic)*ex: old skin cells, human hands and feet having individual digits …
Published	09/08/2023	normal cell disturbance causes either {{c1::adaptation}} or {{c1::injury}}
Published	09/08/2023	irreversible cell injury leads to {{c1::necrosis}} or {{c1::apoptosis}}
Published	09/08/2023	necrosis is usually {{c1::pathologic}}apoptosis can be {{c2::pathologic}} or {{c2::physiologic}} (ex. fetal webbing in hands)
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Published	09/08/2023	{{c1::Autophagy}}: cell eats its own contents → implicated in aging, exercise, and some pathologic processes→ use initiation and nucleation complexes …
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Published	09/08/2023	5 Rs of inflammation*inflammation: {{c6::protective}} host response to injury via cells and chemical mediators- {{c1::recogntion}} of injurious stimul…
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Published	09/08/2023	tissue repair:- mild, superficial injury (skin cuts, surgical incisions) → {{c2::regeneration}}- severe injury (surgical excision of tissue, trauma) →…
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Published	10/05/2023	Apoptosis- has two activating mechanisms... intrinsic pathway = {{c6::mitochondrial}} pathway- occurs when cell is exposed to {{c1::str…
Published	10/05/2023	Necrosis- can be triggered by external factors (like an infection, extremely hot or cold temps) or internal factors (like tissue {{c1::ischemia}}…
Published	10/05/2023	{{c11::coagulative}} necrosis- tissue becomes {{c12::hypoxic}}, most commonly due to ischemia, and dies buts retains some structure→ hypoxia causes {{…
Published	10/05/2023	gangrenous necrosis- also occurs due to hypoxia... some consider it a form of coagulative necrosis - typically affects lower limbs and {{c1::gast…
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