Notes in 01_Parkinson's

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Published 02/10/2024 {{c1::Parkinson’s disease}} is {{c2::a condition where there is a progressive reduction of dopamine in the basal ganglia of the br…
Published 02/10/2024 Presentation of {{c2::Parkinsonism}}A clinical syndrome with ≥ 2 of: {{c1::Bradykinesia (slowness of movement)}} {{c1::Rigidity (stiffness)}} {{c1::T…
Published 02/10/2024 Drugs that induce Parkinsonism  {{c1::dopamine antagonist (e.g. antipsychotics)}} {{c1::anti-emetics (e.g. metoclopramide, prochlorperazine)}} {{…
Published 02/10/2024 {{c1::Lewy body dementia}} is a type of dementia associated with features of {{c2::Parkinsonism}} and {{c2::Visual hallucinations}}
Published 02/10/2024 Diagnosis of Parkinson's disease {{c1::Clinical diagnosis (Parkinsonism: bradykinesia, rigidity, tremor, postural instability)}} {{c1::DaTscan showin…
Published 02/10/2024 Signs that Indicate Diagnosis other than Parkinsonism {{c1::Rapid progression}} {{c1::Symmetrical tremor}} {{c1::Lack of rest tremor}} {{c1::Poor resp…
Published 02/10/2024 Pharmacological Agents used to treat Parkinson's disease{{c1::Monoamine Oxidase-B (MAO-B) Inhibitors (e.g. selegiline, rasagiline)}}{{c1::COMT inhibit…
Published 02/10/2024 Mechanism of Action of MAO-B inhibitors{{c1::MAO-B inhibitors work by inhibiting the action of monoamine oxidase-B enzyme which breaks down dopam…
Published 02/10/2024 Mechanism of Action of COMT inhibitors{{c1::Inhibiting an enzyme called catechol-o-methyltransferase (COMT) which metabolises levodopa in both th…
Published 02/10/2024 Mechanism of Action of Dopamine agonists{{c1::Mimic dopamine in the basal ganglia and stimulate the dopamine receptors}} {{c1::Usually used to de…
Published 02/10/2024 Levodopa is combined with {{c1::peripheral decarboxylase inhibitors (e.g. carbidopa and benserazide)}} to prevent it from being broken down to do…
Published 02/10/2024 Early Treatment of Parkinson's disease {{c1::MAO-B inhibitors (e.g. Selegiline, Rasagiline)}} {{c1::COMT inhibitor (e.g. Entacapone, Tolacapone)}} {{c…
Published 02/10/2024 Late Treatment of Parkinson's disease {{c1::Usage of MAO-B inhibitors, COMT inhibitor, slow release levodopa}} {{c1::Addition of Dopamine agonists}} {…
Published 02/10/2024 {{c2::Dyskinesias}} are side-effects of Parkinson's medications which are associated with {{c1::peak dose levodopa}}
Published 02/10/2024 {{c2::Akinesia}} and {{c2::Neuroleptic malignant syndrome}} are  side-effects of Parkinson's medications which are associated with {{c1::abr…
Published 02/10/2024 {{c2::Dopamine receptor agonists (e.g. pramipexole, ropinirole, rotigotine)}} are Parkinson's medications which are associated with {{c1::hallucinatio…
Published 02/10/2024 Do not give {{c1::antipsychotics (e.g. haloperidol)}} and {{c1::antiemetics (e.g. chlopromazine, metoclopramide)}} to patients with Parkinson’s diseas…
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