Notes in f. Gene Therapy

To Subscribe, use this Key

Status	Last Update	Fields
Published	07/28/2024	What are the 3 strategies for gene/nucleic acid therapeutics?
Published	07/28/2024	{{c1::Gene addition/augmentation}} increases the levels of an mRNA or a protein that is missing or reduced in expression, due to a genetic or epigenet…
Published	07/28/2024	{{c1::Gene expression inhibition}} antagonize mRNA and/or protein levels via RNA-inhibitory mechanisms to reduce expression of a potentially toxic or …
Published	07/28/2024	{{c1::Gene correction}} repairs a specific DNA sequence alteration by a precise gene replacement
Published	07/28/2024	When using a viral vector-based approach for nucleic acid delivery in gene therapy, a {{c1::replication-deficient}} virus is used to deliver non-…
Published	07/28/2024	{{c1::Adenovirus}} delivery vectors are easy to produce and infect a large range of cells, but are not used any more due to illiciting strong immune r…
Published	07/28/2024	{{c1::Retrovirus}} and {{c2::lentivirus}} delivery vectors are difficult to produce and have a moderate gene carrying capacity, however are ineff…
Published	07/28/2024	{{c1::Adeno-associated virus}} are easy to produce, effects many cells, and are useful for in vivo approaches
Published	07/28/2024	{{c1::Adeno-associated viruses}} are best used vectors for in vivo gene therapy approaches
Published	07/28/2024	{{c1::Retroviruses/lentiviruses}} are best used for ex vivo gene therapy approaches
Status	Last Update	Fields