Notes in 04 Receptors in Therapeutic and Toxic Effects

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Published	07/30/2024	{{c1::ED50::ED50/TD50/LD50}} refes to the {{c2::Median Effective Dose::Median Toxic Dose/Median/Effective Dose/Median Lethal Dose}}
Published	07/30/2024	{{c1::LD50::ED50/TD50/LD50}} refes to the {{c2::Median Lethal Dose::Median Toxic Dose/Median/Effective Dose/Median Lethal Dose}}
Published	07/30/2024	{{c1::TD50::ED50/TD50/LD50}} refes to the {{c2::Median Toxic Dose::Median Toxic Dose/Median/Effective Dose/Median Lethal Dose}}
Published	07/30/2024	Variable Relationship(1) Therapeutic Index (TI)(2) Drug Safety{{c1::Inc-Inc::Inc-Inc,Inc-Dec,No Effect}}
Published	07/30/2024	The {{c1::Quantal Dose-Response Curve::(Curve)}} is the curve from where the therapeutic index of a drug is derived from
Published	07/30/2024	The {{c1::Quantal Dose-Response Curve::(Curve)}} is a sigmoid curve from which the minimum dose required to produce a specific response is d…
Published	07/30/2024	{{c1::True::True/False}}LD50 is only experimentally defined on a quantal dose-response curve
Published	07/30/2024	Emax is also determined in the {{c1::graded::graded/quantal}} dose-response curve
Published	07/30/2024	Quantitative Comparison:Drug Safety(1) LD50 = 400; ED50 = 20(2) LD50 = 150; ED50 = 3{{c1::1 < 2::1 > 2, 1 < 2, 1 = 2}}
Published	07/30/2024	The {{c1::therapeutic window}} is the dosage range between the minimum effective therapeutic concentration (Dose MEC) and the minimum toxic …
Published	07/30/2024	Quantitative ComparisonClinical Relevance(1) Therapeutic Index(2) Therapeutic Window{{c1::1 < 2::1 > 2, 1 < 2, 1 = 2}}
Published	07/30/2024	The ideal time to measure PEAK (Minimum Toxic Concentration) on assessing a therapeutic window is {{c1::1-2 hrs after administration::(Time)…
Published	07/30/2024	The ideal time to measure TROUGH (Minimum Effective Concentration) on assessing a therapeutic window is {{c1::before administering next dose…
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