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Notes in
Endocrine Aspects of Male Hypogonadism
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Published
03/15/2025
What type of hormone is testosterone?
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Which cells primarily produce testosterone?
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What percentage of testosterone secretion comes from the adrenal gland?
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Which enzyme converts testosterone to oestrogen?
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What percentage of testosterone is unbound/free in circulation?
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What testosterone level defines male hypogonadism?
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Which condition is characterized by an inability of the testis to produce normal levels of testosterone?
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Which syndrome, characterized by hypogonadism and anosmia, is a cause of secondary hypogonadism?
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What symptom is characteristic of pre-pubertal hypogonadism affecting the voice?
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Which condition refers to undescended testes seen in pre-pubertal hypogonadism?
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What is the normal range for total testosterone levels in serum?
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What form of testosterone is referred to as "free and weakly bound"?
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What percentage of testosterone is bound to SHBG?
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Name a condition that decreases SHBG levels.
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Which medication blocks oestrogen receptors in the hypothalamus and pituitary to stimulate testosterone production?
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Which type of cancer is a contraindication for testosterone replacement?
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How often should therapy response be reviewed after starting testosterone replacement therapy (TRT)?
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Which oral testosterone replacement avoids first-pass metabolism?
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Which testosterone replacement form is recommended for patients who prefer a more physiological approach with fewer hormonal fluctuations?
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Which of the following is NOT a function of testosterone?
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Which hormone stimulates Leydig cells to produce testosterone?
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Which of the following is NOT a cause of primary hypogonadism?
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Which of the following conditions is commonly associated with combined hypogonadism?
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Which of the following is NOT a non-specific post-pubertal symptom of hypogonadism?
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Which investigation measures the amount of active, unbound testosterone?
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Which of the following conditions is associated with an increase in SHBG levels?
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Which investigation is essential for diagnosing possible pituitary masses in hypogonadism?
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Which of the following is NOT a requirement when starting Jatenzo therapy?
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Which testosterone replacement method is most likely to cause fluctuations in libido, sexual function, and mood?
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Arrange the following in the correct order for the Hypothalamic-Pituitary-Testis axis:
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Arrange the following in the sequence of events for secondary hypogonadism pathophysiology:
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Arrange the stages of symptom development in hypogonadism based on the timing of deficiency:
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Arrange the steps for clinical diagnosis of hypogonadism:
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Arrange the steps for monitoring patients after starting TRT:
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True or false: Endocrine Aspects of Male Hypogonadism 1
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True or false: Endocrine Aspects of Male Hypogonadism 2
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Match the condition to its effect on SHBG:
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DHT | Oestradiol | Testosterone
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Gynaecomastia | Loss of libido | Reduced cognitive function | Decreased bone mass | Anaemia
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Exogenous testosterone | Aromatase inhibitors (Letrozole) | Clomiphene
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Jatenzo (oral) | Sublingual drops | IM Injections | Transdermal patches | Subcutaneous pellets
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Klinefelter’s Syndrome | Hyperprolactinaemia | Alcoholism | Cryptorchidism | Congenital GnRH deficiency | Liver Cirrhosis
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Serum testosterone | LH/FSH | SHBG | Semen analysis | MRI | DEXA scan
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Fill in the missing values in the table on male hormones and cells:
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Match the causes to the correct type of hypogonadism:
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Complete the table regarding testosterone investigations and normal ranges:
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Complete the table regarding monitoring and therapy adjustments : Parameter, Monitoring Frequency, Action if Abnormal
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Testosterone is converted into [DHT] by the enzyme 5α-reductase.The enzyme [Aromatase] converts testosterone into oestrogen.Only [5%] of testosterone …
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Hyperprolactinaemia, commonly caused by a [pituitary adenoma], is a cause of secondary hypogonadism. Pre-pubertal hypogonadism may result in [cryptorc…
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03/15/2025
[SHBG] levels can influence the amount of free, active testosterone in the body. The medication [Letrozole] acts as an aromatase inhibitor to prevent …
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[Haematocrit] levels should be monitored regularly during TRT, and therapy should be reduced if levels are elevated. [Jatenzo] is the first FDA-approv…
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Status
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