Notes in Case 1: Acute Bleeding

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Status	Last Update	Fields
Published	11/30/2023	{{c1::Primary}} hemostasis forms a weak platelet plug
Published	11/30/2023	Primary hemostasis is mediated by interactions between {{c1::platelets}} and the {{c2::vessel wall}}
Published	11/30/2023	{{c1::Secondary}} hemostasis stabilizes the platelet plug
Published	11/30/2023	Is the plug formed by primary hemostasis stable?{{c1::No}}
Published	11/30/2023	Following upregulation of GpIIb/IIIa, platelets aggregate at the site of injury via crosslinking of GpIIb/IIIa receptors with {{c1::fibrinogen}} to ma…
Published	11/30/2023	In the first step of wound healing, {{c1::hemostasis}}, a {{c2::blood clot}} forms at the wound along with a {{c2::platelet plug}} and fibrin and affe…
Published	11/30/2023	Primary hemostasis begins with {{c1::adhesion}}, followed by {{c2::vWF}} binding GPIb, leading to a conformational change of the platelets which expos…
Published	11/30/2023	Secondary hemostasis involves a {{c1::coagulation cascade}} leading to clot formation.
Published	01/02/2024	How does body reduce flow to achieve HemostasisVeins - {{c1::Manual Pressure}}Arteries - {{c2::endothelial factors}} lead to {{c2::vasoconstriction}} …
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Published	11/30/2023	Aspirin MOA:Blocks {{c1::COX-1}} synthesis of {{c2::prostaglandins and TXA2}} → prevents activation of {{c1::thromboxane A2 receptor}} → prevents {{c2…
Published	01/02/2024	Warfarin MOAInhibits {{c1::vitamin K epoxide reductase}} → depletion of {{c1::vitamin K}} → inhibition of {{c1::vitamin K-dependent clotting factors (…
Published	11/30/2023	{{c1::Clotting factors}} are typically synthesized in the liver {{c2::RBCs, WBCs, and megakaryocytes/platelets}} are synthesized in the bone marr…
Published	11/30/2023	Acute bleeds that have happened over a {{c1::longer::longer/shorter}} time present with greater anemia
Status	Last Update	Fields