Notes in 06. Electrophysiology

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Published 02/28/2025 Electrical Conduction Pathway in the Heart:Initiation at the {{c1::SA::AV/SA}} node = causes {{c2::atria}} to contract and push blood into the {{c2::v…
Published 02/28/2025 The initial depolarization of AV node AP is done be {{c1::Ca2+::Ca2+/Na+}} channels
Published 02/28/2025 Tropies:{{c1::Chronotropy}} (heart rate) = rate at which {{c5::SA::AV/SA}} node generates APs{{c2::Inotropy}} (contractility) = strength of myocardial…
Published 02/28/2025 {{c1::image-occlusion:rect:left=.1175:top=.1669:width=.0859:height=.0591:oi=1}}{{c2::image-occlusion:rect:left=.4108:top=.1625:width=.0932:height=.063…
Published 02/28/2025 SA Node Action Potential: Phase 4. Gradual Depolarization {{c1::Funny (HCN) channel::channel type}} is activated during {{c2::hyperpolarization::…
Published 02/28/2025 SA Node Action Potential: Phase 0. Slow Depolarization {{c1::L-type Ca2+ channels::channel type}} activate = leads to the upstroke (dep…
Published 02/28/2025 SA Node Action Potential: Phase 3. Repolarization{{c1::Delayed rectifier VG channels::channel type}} open = {{c2::K+::ion}} efflux = repolarizati…
Published 02/28/2025 Increase in heart rate (chronotropic) from sympathetic activation increases influx of {{c1::Ca2+}} and {{c1::Na+}} during {{c2::phase 4::phase}} …
Published 02/28/2025 Parasympathetic activity decreases heart rate by:{{c1::ACh}} inhibits adenylate cyclase = decreases {{c2::cAMP}} = decrease activity of {{c3::HCN funn…
Published 02/28/2025 An increase in {{c2::cAMP}} leads to increased activity of {{c1::HCN funny channel::channel type}} = more Na+ influx
Published 02/28/2025 {{c1::PKA}} effects:Increases {{c3::L-type calcium channel::channel type}} = accelerates SA node AP Increases {{c2::delayed rectifier K+ cha…
Published 02/28/2025 PNS reduces heart rate by = ACh binding to {{c1::M2}} receptors = reduces {{c2::cAMP}} and increases {{c2::K+}} efflux
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