Notes in NAS X (Degeneration & regeneration of trauma )

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Published	11/11/2024	The main caues of degeneration of nerves are the {{c1::genetics of the body}}, the {{c1::natural process of aging}} and {{c1::aquired causes through i…
Published	11/11/2024	Injured {{c1::peripheral}} nerves have a capacity to {{c2::regenerate}} and re-{{c2::innervate}} effectors.
Published	11/11/2024	CNS axons do not {{c1::regenerate}} when injured.
Published	11/11/2024	An insult is the {{c1::cause}} of some kind of {{c1::physical or mental injury}}.
Published	11/11/2024	{{c1::Seddon's classsification}} is a system used to rate {{c2::injuries}} to {{c2::nerves}} based on the degree to which the {{c2::insult}} reaches t…
Published	11/11/2024	There are 3 levels of depths of seddon's classifications: {{c1::superficial}}, {{c1::intermediate}} and {{c1::deep}}.
Published	11/11/2024	{{c2::Neuropraxia}} is the {{c1::temporary loss of a neurone function}}.
Published	11/11/2024	{{c1::Axonotmesis}} is {{c2::an injury to the axons and mylelin sheath in a peripheral nerve}}, usualy due to a form of {{c2::crushing injury}}.
Published	11/11/2024	{{c2::Neurotmesis}} is the {{c1::complete transection of a nerve including all the layers}}.
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Published	11/11/2024	During {{c1::axonotmesis}}, the nerve is split into 2 parts: the {{c2::proximal}} segment (is {{c3::connected}} to the cell body) and {{c2::distal}} s…
Published	11/11/2024	During axonotmesis, the distal segment stops {{c1::conducting action potentials}} and begin to undertake {{c1::wallerian degeneration}}.
Published	11/11/2024	When neurons are injured, {{c1::schwann cells}}/{{c1::oligodenrocytes}}, {{c1::astrocytes}} and {{c1::microglia}} are critical in supporting it and it…
Published	11/11/2024	After a nerve injury, both sides of the cut axons are exposed and begin leaking {{c1::intracellular fluid}}.
Published	11/11/2024	During {{c2::wallerian degeneration}}, the {{c1::axons}} and {{c1::myelin sheath}} of the {{c1::distal}} segment are broken down and {{c1::phagocytes}…
Published	11/11/2024	Days after nerve injury, the proximal segment presents its self as {{c2::chromatolysis}}, with the nucleus {{c1::moving to the side}} and the nissl bo…
Published	11/11/2024	Due to chromatolysis, the the porximal segment begins to grow {{c1::nerve sprouts}} in order to try to {{c1::reinnervate}} the effector muscle.
Published	11/11/2024	In terms of examination of a denervated muscle, the affected muscle is immediately {{c1::paralysed}}, {{c1::areflexic}}, {{c1::atonic}} and starts to …
Published	11/11/2024	during axonotmesis, macrophages will release {{c1::mitogens}}, which induce {{c1::schwann}} cells to begin to {{c1::repopulate}}.
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