Notes in 02_Rheumatoid Arthritis

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Published	02/10/2024	{{c1::Rheumatoid Arthritis}} is a chronic, autoimmune, systemic illness characterised by a symmetrical peripheral arthritis and other systemic feature…
Published	02/10/2024	Presentation of {{c1::Rheumatoid Arthritis}} {{c2::Symmetrical}} {{c2::Polyarthritis (more than one joint)}} {{c2::Pain at rest}} {{c2::Stiffness…
Published	02/10/2024	Clinical signs of Rheumatoid Arthritis {{c1::Tenderness}} {{c1::Synoival swelling}} {{c1::Limitation of Movement}} {{c1::Rheumatoid nodules}} {{c1::He…
Published	02/10/2024	Gender associated with higher levels of Rheumatoid arthritis{{c1::F:M — 3:1}}
Published	02/10/2024	Pathophysiology of Rheumatoid arthritis{{c1::Autoimmune inflammation involving TNF-a, IL-6 and many other cytokines and inflammatory cells causing syn…
Published	02/10/2024	Systemic symptoms of Rheumatoid arthritis{{c1::Scleritis and Episcleritis}}{{c1::Fatigue}}{{c1::Weight loss}}{{c1::Anaemia}}{{c1::Interstitial Lung Di…
Published	02/10/2024	The meaning of seropositive and seronegative?It is based on autoantibody production, dividing RA patients into two groups Seropositive RA {{c1::Rheu…
Published	02/10/2024	Diagnostic criteria of Rheumatoid arthritis come from the American College of Rheumatology (ACR) {{c1::The joints that are involved (more and sma…
Published	02/10/2024	Which score indicates a diagnosis of Rheumatoid arthritis? Scores are added up and a score ≥ {{c1::6}} indicates a diagnosis of rheumatoid arthri…
Published	02/10/2024	Investigations of Rheumatoid Arthritis {{c1::History-taking and Examination (Symptoms of Synovitis)}} {{c1::Immunology/Serology: Rheumatoid Factor (I…
Published	02/10/2024	The Score used to monitor Rheumatoid arthritis activity is {{c1::DAS28}}
Published	02/10/2024	Rheumatoid arthritis — Therapeutic Categories{{c1::NSAIDs}}{{c1::Disease Modifying Anti Rheumatic Drugs (DMARDs)}}{{c1::Biological Therapies}}{{c1::Co…
Published	02/10/2024	DMARDs include which medications?{{c1::Methotrexate}}, {{c1::Sulfasalazine}}, {{c1::Hydroxychloroquine}}, {{c1::Leflunomide}}
Published	02/10/2024	The cornerstone for Combination therapy with DMARD and biologic therapy in Rheumatoid arthritis is {{c1::Methotrexate}}
Published	02/10/2024	Both {{c1::Methotrexate}} and {{c1::Sulfasalazine}} are DMARDs that require {{c2::folic acid}} supplementation
Published	02/10/2024	Examples of TNF-a inhibitors include ({{c1::adalimumab}}, {{c1::infliximab}}, and {{c1::etanercept}})
Published	02/10/2024	{{c1::Rituximab}} is an Anti B cell therapy. It is a monoclonal antibody that targets the CD20 protein on the surface of&nbsp…
Published	02/10/2024	Approach to Managing Rheumatoid arthritis {{c1::Early and aggressive intervention is the key to obtaining optimal outcomes in the management of RA}} {…
Published	02/10/2024	Treatment Strategy of Early and Aggressive Rheumatoid arthritis {{c1::Sequential Monotherapy}} {{c1::Combination: step up, step down, parallel}} {{c1:…
Published	02/10/2024	First line of Rheumatoid arthritis treatment is monotherapy with {{c1::methotrexate}}, {{c1::leflunomide}} or {{c1::sulfasalazine}}.
Published	02/10/2024	{{c1::NSAIDs}} in Rheumatoid arthritis are widely used for symptomatic relief. They do not alter the disease progression in any way
Published	02/10/2024	Long-term usage of {{c1::corticosteroids e.g. Prednisolone}} in Rheumatoid arthritis is associated with poorer outcomes but there is short term b…
Published	02/10/2024	Long-term usage of corticosteroids e.g. Prednisolone in Rheumatoid arthritis is associated with which condition?{{c1::Osteoporosis}}
Published	02/10/2024	{{c1::DMARD}} therapy should be initiated ASAP after diagnosis of Rheumatoid Arthritis
Published	02/10/2024	NICE guidelines state to use {{c1::TNF-a}} therapy only after {{c2::2 other DMARD’s}} have been unsuccessfulin treating Rheumatoid arthritis.
Published	02/10/2024	Side effect of Anti-TNF-α therapiesAssociated with {{c1::reactivation of latent TB infections }}
Published	02/10/2024	A common side effect that can be caused by all DMARDS is{{c1::Myelosuppression – (bone marrow suppression)}} and {{c1::rash}}
Published	02/10/2024	{{c1::Folic acid}} is given with Methotrexate to reduce its side effect of GI disturbance
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