Notes in Case 1: SLE

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Status	Last Update	Fields
Published	02/01/2024	Which antimalarial can be used to treat rheumatoid arthritis and SLE?{{c1::Hydroxychloroquine}}
Published	02/01/2024	What type of hypersensitivity reaction is lupus-associated glomerulonephritis? {{c1::Type III}}
Published	02/01/2024	The gene that most affects the development of SLE is {{c1::HLA}}
Published	02/01/2024	Autoimmunity is the result of {{c1::genetics}} + {{c1::trigger}}
Published	02/01/2024	The 3 lab tests for anti-nuclear antibodies (ANA) are Indirect immunofluorescence, Enzyme immunoassay, and Multiplex immunoassay. Which…
Published	02/01/2024	It is significantly easier for the body to clear {{c1::large::size}} immune complexes
Published	02/01/2024	In SLE, anti-nuclear antibodies arise because of some trigger that causes excess {{c1::cell death (apoptosis & necrosis)}}
Published	02/01/2024	In SLE, anti-nuclear antibodies arise because nuclear antigens activate {{c1::TLRs::class of PRRs}} in the {{c2::endosome::cellular location…
Published	02/01/2024	In SLE, the activation of TLRs in dendritic cells upregulates production of {{c1::type I interferons::cytokine(s)}}
Published	02/01/2024	In a skin biopsy from a SLE patient, where do you expect to see immune complex deposition?{{c1::Dermo-epidermal junction}}
Published	02/01/2024	The most serious complication of SLE is {{c1::glomerulonephritis}}
Published	02/05/2024	Treatment of SLE includes {{c2::antimalarials hydroxychloroquine}}, general {{c1::immunosuppressants}}, and targeted drugs
Published	02/01/2024	Anifrolumab is a monoclonal antibody against {{c2::IFN-α}}, useful in the treatment of SLE
Published	02/01/2024	Antimalarials are helpful in treating SLE because they prevent {{c1::acidification of the lysosome}}, which prevents nuclear antigen from binding…
Published	02/01/2024	SLE is associated with certain alleles for the HLA genes that encode MHC class {{c1::II}} molecules
Published	02/05/2024	What type of hypersensitivity reaction is systemic lupus erythematosus (SLE)? {{c1::Type III* HSR (immune complex deposition)}}
Published	02/01/2024	First-line treatment for SLE includes {{c1::glucocorticoids}} for flare ups
Published	02/01/2024	Common causes of death in SLE patients include {{c1::renal}} failure, {{c2::infection}}, and {{c3::cardiovascular}} disease
Published	02/01/2024	(-) {{c1::ANA (sensitive)}} = rules OUT lupus
Published	02/05/2024	Why is the diagnosis of lupus nephritis important to make in the setting of SLE?{{c1::Severity of the disease dictates treatment}}
Status	Last Update	Fields