Notes in 03_Autoimmunity

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Published	02/10/2024	{{c1::Immunological tolerance}} is {{c2::unresponsiveness to an antigen that is induced by previous exposure to that antigen}}
Published	02/10/2024	{{c1::Tolerogens}} are {{c2::antigens that induce tolerance}}
Published	02/10/2024	{{c1::Self-Tolerance}} is {{c2::tolerance to self-antigens (the body’s own antigens), which is a fundamental property of the normal immune system}}
Published	02/10/2024	{{c1::Autoantibodies}} are {{c2::antibodies secreted by B cells that are directed at normal cellular components, these are present in healthy individu…
Published	02/10/2024	{{c1::Molecular mimicry}} means that {{c2::structural similarity between self-proteins and microbial antigens may trigger an autoimmune response}}
Published	02/10/2024	{{c1::Autoimmune disease}} involves {{c2::failure of the mechanism that prevents the specific immune cells from recognising and attacking self-antigen…
Published	02/10/2024	Describe B Cell Central Self Tolerance (Location and Mechanism) {{c1::B Cells develop their specific antibodies in the bone marrow}} {{c1::The bone ma…
Published	02/10/2024	Describe T Cell Central Self Tolerance (Location and Mechanism) known as T Cell Education First: {{c1::T Cells express both CD4 and CD8, one must be s…
Published	02/10/2024	During {{c1::inflammation}} or {{c1::tissue damage}}, there are higher levels of self-antigens presented to immune cells, under these conditions there…
Published	02/10/2024	Causes of Breakdown of T Cell Tolerance (Risk Factors for Autoimmune Disease) {{c1::Genetic predisposition}} Environmental factors {{c1::Infections …
Published	02/10/2024	Features of {{c2::Non-Organ Specific}} Autoimmune Disease {{c1::Multiple organs}} {{c1::Widely distributed autoimmune responses against self…
Published	02/10/2024	Features of {{c2::Organ Specific}} Autoimmune Disease {{c1::Restricted to one organ}} {{c1::Usually endocrine glands}}
Published	02/10/2024	Treatment of Autoimmune Diseases can be either via {{c1::Suppression}} or {{c1::Replacement}}
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