Notes in 08 Autoimmine Diseases

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Published	07/30/2024	SLE usually affects px who are {{c1::female and child bearing}}
Published	07/30/2024	SLE may typically have {{c1::3::n}} autoantibodies present simultaneously
Published	07/30/2024	SLE Diagnosis:{{c1::4 of clinical and immunologic criteria present at any time (not necessarily concurrently), including at least 1 clinical and 1 imm…
Published	07/30/2024	The most common test for SLE requested is {{c1::ANA}} using {{c1::indirect immunofluorescence::method}}
Published	07/30/2024	Is ANA specific for SLE?{{c1::N. Even if ANA is (-), we cannot rule it out::Y/N}}
Published	07/30/2024	ANA is categorized based on specificity for:{{c1::DNAHistonesNon-histone proteinsNucleolar antigens::4}}
Published	07/30/2024	When reporting ANA (+), also add the patient's {{c1::titer}}
Published	07/30/2024	[Identify] (TAKE THE TIME TO LOOK AT ALL IMAGES){{c1::Homogenous/Diffuse Nuclear}} ANA Pattern
Published	07/30/2024	[Identify] (TAKE THE TIME TO LOOK AT ALL IMAGES){{c1::Speckled}} ANA Pattern
Published	07/30/2024	[Identify] (TAKE THE TIME TO LOOK AT ALL IMAGES){{c1::Centromeric}} ANA Pattern
Published	07/30/2024	[Identify] (TAKE THE TIME TO LOOK AT ALL IMAGES){{c1::Nucleolar}} ANA Pattern
Published	07/30/2024	{{c3::Homogenous or Diffuse Nuclear}} ANA Pattern May indicate presence of antibody against... {{c1::ChromatinHistonesOccasionally dsDNA::3}}Think of:…
Published	07/30/2024	{{c2::Speckled}} ANA Pattern May indicate presence of antibody against... {{c1::Sm antigenRibonucleoproteinSS-A reactive antigenSS-B reactive antigen:…
Published	07/30/2024	{{c2::Centromeric and Nucleolar}} ANA Pattern May indicate presence of antibody against... {{c1::RNA}}Think of: {{c3::Systemic Sclerosis}}
Published	07/30/2024	The most common and least specific ANA pattern is {{c1::speckled}}
Published	07/30/2024	There are 3 Autoantibodies in SLE that are considered Specific for SLE:{{c1::Anti-dsDNAAnti-SmAntiphospholipid Antibodies}}
Published	07/30/2024	Anti-dsDNA has tropism for {{c1::glomerular basement membrane}}
Published	07/30/2024	Aside from SLE, Anti-dsDNA can also increase in {{c1::chronic hepatitis, infectious mononucleosis, biliary cirrhosis::3 diseases}}
Published	07/30/2024	The 4 Extractable Nuclear Antigens are:{{c1::Anti-SmnRMPSS-ASS-B}}
Published	07/30/2024	Anti-Sm bind to {{c1::RNA and proteins::substance}}
Published	07/30/2024	Anti-Sm is more common in px who are {{c1::Black and Asian::2 ethnicities}}
Published	07/30/2024	Why should pregnant px who suffer from miscarriages be worked up for APAS?{{c1::APAS causes one to be in a hypercoaguable state}}
Published	07/30/2024	Antiphospholipid Antibodies are a group of antibodies against:Phospholipids{{c1::anticardiolipin IgG/IgManti-β2 glycoprotein I IgG/IgMlupus anticoagul…
Published	07/30/2024	Primary Sjogren Syndrome Clinical Findings:{{c1::Isolated Sicca Complex}}
Published	07/30/2024	Secondary Sjogren Syndrome Clinical Findings:{{c1::Isolated Sicca ComplexAnother SARD}}
Published	07/30/2024	[QC] Risk for B Cell Lymphoproliferative Disorders (Hodgkin’s Lymphoma or Non-Hodgkin’s Lymphoma)1. Primary Sjogren Syndrome2. Secondary Sjogren Syndr…
Published	07/30/2024	Antibodies in Sjogren Syndrome:{{c1::Anti SS-A/RoAnti SS-B/La}}
Published	07/30/2024	[QC] Prevalence in Sjogren Syndrome1. Anti SS-A/Ro2. Anti SS-B/La{{c1::A}}
Published	07/30/2024	{{c1::Systemic Sclerosis or Scleroderma}} - Multisystem connective tissue disorder manifesting as vascular lesions and tissue fibrosis usually in…
Published	07/30/2024	2 Categories of Systemic Sclerosis or Scleroderma:{{c1::Diffuse Cutaneous SSc (dcSSc)Limited Cutaneous SSc (lcSSc)}}
Published	07/30/2024	[QC] Rapidity of Progression1. dcSSc2. lcSSc{{c1::A}}
Published	07/30/2024	[QC] Prognosis1. dcSSc2. lcSSc{{c1::B}}
Published	07/30/2024	[QC] Visceral Involvement1. dcSSc2. lcSSc{{c1::A}}
Published	07/30/2024	In lcSSc, the disease is confined to the {{c1::distal extremities and the face::body parts}}
Published	07/30/2024	lcSSc Clinical Findings:{{c1::CRESTCalcinosis CutisRaynaud's PhenomenonEsophageal DysmotilitySclerodactylyTelangiectasia}}
Published	07/30/2024	Antibodies in Systemic Sclerosis or Scleroderma:{{c1::Anti-CentromereAnti-Scleroderma (Scl-70)/Anti-Topoisomerase-I::2}}
Published	07/30/2024	The most common Anti-Centromere antibody in Systemic Sclerosis is Anti-CENP-{{c1::B}}
Published	07/30/2024	[QC] Systemic Sclerosis Severity1. Anti-CENP2. Anti-Scleroderma (Scl-70)/ Anti-Topoisomerase-I{{c1::B}}
Published	07/30/2024	[QC] Presence of Anti-CENP in Systemic Sclerosis1. dcSSc2. lcSSc{{c1::B}}
Published	07/30/2024	[QC] Anti-CENP in Systemic Sclerosis1. Younger age onset2. Older age onset{{c1::B}}
Published	07/30/2024	[QC] Specificity for Systemic Sclerosis1. Anti-CENP2. Anti-Scleroderma (Scl-70) or Anti-Topoisomerase-I{{c1::B}}
Published	07/30/2024	[QC] Pulmonary Fibrosis, MSK, Cardiac involvement1. Anti-CENP2. Anti-Scleroderma (Scl-70) or Anti-Topoisomerase-I{{c1::B}}
Published	07/30/2024	[QC] flexion contractures and renal vascular damage1. Anti-CENP2. Anti-Scleroderma (Scl-70) or Anti-Topoisomerase-I{{c1::B}}
Published	07/30/2024	[QC] Earlier Development of Raynaud's Phenomenon1. Anti-CENP2. Anti-Scleroderma (Scl-70) or Anti-Topoisomerase-I{{c1::B}}
Published	07/30/2024	RA Clinical Findings:Chronic symmetric erosive arthritis of peripheral joints{{c1::Subcutaneous nodulesVasculitisInterstitial fibrosisNormochromic, no…
Published	07/30/2024	RA Etiology: Overproduction of {{c1::TNF, IL-1, and IL-6::3 pro-inflammatory mediators}}
Published	07/30/2024	[QC] RA 1. M2. F{{c1::B}}
Published	07/30/2024	Antibodies in RA:Rheumatoid Factor{{c1::Anti-Cyclic Citrullinated Peptide (Anti-CCP)Anti-Keratin AbAnti-Perinuclear Factor::3}}
Published	07/30/2024	Rheumatoid factor is directed against the F{{c1::c}} portion of antibodies
Published	07/30/2024	RA with erosions is associated w/ Rheumatoid factor is directed against Ig{{c1::A}}
Published	07/30/2024	Anti-{{c1::CCP}} Antibodies are an early and specific marker for RA when RF (-)
Published	07/30/2024	Anti-{{c1::CCP}} Antibodies are associated w/ severity, erosion, relapse, and mortality in RA
Published	07/30/2024	[QC] Sensitivity for RA1. AKA2. APF{{c1::B}}
Published	07/30/2024	[QC] Specific for RA1. AKA2. APF{{c1::A}}
Published	07/30/2024	Idiopathic Inflammatory Myopathies are the Collective Term for:{{c1::PolymyositisDermatomyositisNecrotizing MyopathiesInclusion Body Myositis::4 Disea…
Published	07/30/2024	{{c1::Necrotizing Myopathies}} - Idiopathic Inflammatory Myopathies that occur on adults after exposure to certain viral infections / statins
Published	07/30/2024	Idiopathic Inflammatory Myopathies Clinical Findings:{{c1::Muscle weakness with pain and tenderness (muscle inflammation)}}
Published	07/30/2024	Idiopathic Inflammatory Myopathies Biopsy:{{c1::Inflammatory infiltrates in skeletal muscle with necrosis and degeneration}}
Published	07/30/2024	Dermatomyositis Clinical Findings:Inflammatory infiltrates in skeletal muscle with necrosis and degeneration{{c1::Maculopapular or eczema-like skin le…
Published	07/30/2024	Antibodies in Idiopathic Inflammatory Myopathies:{{c1::Anti-PML/SclAntibodies to aminoacyl-tRNA synthetases (ARS) (Anti-Jo-1, Anti-PL-7 (threonyl…
Published	07/30/2024	Anti-{{c1::Jo-1}} is the most prevalent antibody to aminoacyl-tRNA synthetases (ARS)
Published	07/30/2024	[QC] Anti-Jo-11. Polymyositis2. Dermatomyositis{{c1::B. Not seen in polymyositis}}
Published	07/30/2024	Other Laboratory Tests for Idiopathic Inflammatory Myopathies:{{c1::ESRTotal CPKLDH::3}}
Published	07/30/2024	{{c2::Mixed Connective Tissue Disease}} - Combination or overlap of features usually associated with SLE, systemic sclerosis, and polymyositis.&n…
Published	07/30/2024	IFA using {{c1::Hep-2}} cells derived from laryngeal squamous cell carcinoma is the preferred screening immunoassay to detect most clinicall…
Published	07/30/2024	Usual cut off for a positive test in immunofluorescence technique is 1:{{c1::160}} titer
Published	07/30/2024	We should know this already just read this {{c1::HAHAHAH}}
Status	Last Update	Fields