Notes in Week 5 Pharm

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Status	Last Update	Fields
Published	02/03/2025	Tacrolimus MOA: {{c1::Binds to FKBP to inhibit calcineurin and NFAT}}Inhibits phosphatase activity of {{c1::calcineurin}}Prevents dephosphorylation an…
Published	02/01/2025	Tacrolimus is used to treat {{c1::psoriasis}} and {{c1::atopic dermatitis}}
Published	02/01/2025	The adverse effects of Tacrolimus include:Topical: does not cause skin {{c1::thinning}} and safe to use on face, axillae, and groinOral: highly {{c1::…
Published	02/01/2025	Dupilumab MOA: {{c1::anti-IL4R antibody}}Inhibits IL-{{c1::4}} and IL-{{c1::13}} signaling↓Ig{{c1::E}} levels
Published	02/01/2025	Dupilumab is used to treat severe and refractory {{c1::atopic dermatitis}} and {{c1::eosinophilic}} asthma
Published	02/01/2025	The adverse effects of dupilumab include:{{c1::Injection site}} reaction{{c1::Oropharyngeal}} pain{{c1::Eosinophilia}}
Published	02/01/2025	Calcipotriene MOA: {{c1::Vitamin D3 analog}}Activates VitD receptor in {{c1::keratinocytes}}, dermal {{c1::fibroblasts}}, and {{c1::immune}} cell…
Published	02/01/2025	Calcipotriene is used to treat {{c1::psoriasis}} (with/without topical steroids) and {{c1::actinic keratoses}} (with 5-FU cream)
Published	02/01/2025	Adverse effects of calcipotreine:{{c1::Skin}} irritation{{c1::Hypercalcemia}}
Published	02/01/2025	Mupirocin MOA: {{c1::Reversible isoleucyl t-RNA synthetase inhibitor}}Inhibits {{c1::protein}} production
Published	02/01/2025	Mupirocin therapeutics:MRSA and MSSA that cause {{c1::Impetigo}}{{c1::Impetiginized eczema}}{{c1::Folliculitis}}
Published	02/01/2025	Adverse effects of mupirocin:{{c1::Allergic}} reactions{{c1::Skin}} irritation
Published	02/01/2025	Clindamycin MOA: {{c1::Reversible 50S inhibitor}} (bacteriostatic)Prevents {{c1::peptide}} bond formation
Published	02/03/2025	Adverse effect of clindamycin is {{c1::pseudomembranous enterocolitis i.e. C. difficile}}
Published	02/03/2025	Tretinoin / Isotretinoin MOA: {{c1::Retinoic acid receptor (RAR) agonist}}Regulates gene expression to help remove stuck {{c1::corneocytes}}
Published	02/03/2025	Tretinoin is a {{c1::topical}} used to treat {{c1::comedonal}} acne
Published	02/03/2025	Isotretinoin is a {{c1::systemic}} drug is used to treat severe, resistant, {{c1::nodular}}/{{c1::cystic}} acne
Published	02/03/2025	Clindamycin is a {{c1::topical}} used to treat inflammatory {{c1::papules}} and {{c1::pustules}}
Published	02/01/2025	Tretinoin / isotretinoin adverse effects:{{c1::Erythema}}{{c1::Peeling}}{{c1::Dry}} skin{{c1::Sun}} sensitivity{{c1::Teratogenic}}
Published	02/10/2025	5-Fluorouracil MOA: {{c1::Thymidylate synthase (TS) inhibitor}}Prevents {{c1::DNA}} synthesis by inhibiting the production of {{c1::dTMP}}FUPT ge…
Published	02/01/2025	5-Florouracil is a topical used to treat {{c1::actinic keratoses::skin problem}}
Published	02/01/2025	The adverse effect of 5-Fluorouracil is {{c1::myelosuppression}}
Published	02/01/2025	Imiquimod MOA: {{c1::TLR7 agonist}}Stimulates {{c1::innate}} and {{c1::adaptive}} immune responseInduces inflammatory {{c1::cytokine}} and {{c1::…
Published	02/05/2025	Imiquimod is a {{c1::topical}} used to treat {{c1::actinic keratoses}}
Published	02/01/2025	Imiquimod adverse effects:{{c1::Weeping}}{{c1::Erythema}}{{c1::Edema}}{{c1::Erosion}}{{c1::Flaking}}{{c1::Scabbing}}
Published	02/05/2025	Aminolevulinic acid (ALA) MOA: Produces {{c1::ROS}} when exposed to {{c1::blue light}} which causes {{c1::apoptosis}}Absorbed by {{c1::skin}} and conv…
Published	02/05/2025	Aminolevulinic acid is a {{c1::topical}} used to treat {{c1::actinic keratoses}}
Published	02/02/2025	Adverse effect of aminolevulinic acid is {{c1::skin irritation}}
Published	02/03/2025	Topical corticosterioid adverse effects:{{c1::Skin thinning}}{{c1::Hypopigmentation}}{{c1::Allergic reaction}}
Published	02/05/2025	What vehicle is most effective for topical drug solutions?{{c1::Ointments}} because they are {{c1::lipophilic}}
Published	02/03/2025	What potency is triamcinolone?{{c1::Medium}}
Published	02/03/2025	Tretinoin / isotretinoin are {{c1::first}} generation. These drugs are the {{c1::least::least/most}} specific
Status	Last Update	Fields