Notes in IE 5 Physio Phar 111 Lec 3

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Status	Last Update	Fields
Published	10/29/2023	Pain -- {{c1::unpleasant sensory and emotional experience associated with actual or potential tissue damage or described as damage}}
Published	10/29/2023	pain is highly subjective – results from {{c1::sensory input, influenced by personality, environment, emotion}}
Published	10/29/2023	Acute pain – {{c1::sudden onset, subsides quickly once cause removed and healing is established}} Chronic Pain – {{c2::lasts 6 months and persists eve…
Published	10/29/2023	Components of pain - Sensory: {{c1::pricking, burning, stabbing, aching ...}} - Affective: {{c1::hurting, depression}} - Autonomic: {{c1::changes in H…
Published	10/29/2023	somatic pain
Published	10/29/2023	deep pain
Published	10/29/2023	Visceral Pain
Published	10/29/2023	{{c7::Free nerve endings}} – {{c1::pain and temperature }}{{c6::Merkel’s disc, Meissner’s corpuscle, Hair follicle receptor}} – {{c2::touch}}&nbs…
Published	10/29/2023	Primary afferent pain fibers – nociceptors - Specific sensory neurons - Activated by {{c1::noxious stimuli to skin or deep subcutaneous tissues}} - Sm…
Published	10/29/2023	A𝛿 fibers
Published	10/29/2023	C fibers
Published	10/29/2023	Mechano-nociceptors ({{c1::A𝛿 & C fibers}}) – {{c2::pressure }}Thermal-nociceptors ({{c2::A𝛿 & C fibers}}) – {{c3::temp. }}Polymodal…
Published	10/29/2023	Neo- Spinothalamic pain pathway Nociceptor → {{c1::cell body (Dorsal root ganglion)}} → {{c2::spinal cord (basal lamina 1 + 2)}} → {{c1::Lateral Spino…
Published	10/29/2023	Local anesthetics – {{c1::prilocaine, lidocaine, mepivacaine, bupivacaine}}
Published	10/29/2023	Local anesthetics as pain killers- Block nerve conduction in the pain fiber by {{c1::blocking Na channels}} 1. {{c2::Drug becomes ionized in the body}…
Published	10/29/2023	Tissue damage causes… 1. {{c1::Persistent pain}} 2. {{c2::Hyperalgesia}} – {{c3::increased sensitivity to pain}} 3. {{c3::allodynia}} – {{c2::pain due…
Published	10/29/2023	pain response1. {{c1::Tissue damage}} 2. {{c2::K+, 5-HT, Prostaglandin (PG), Bradykinin (BK) release}} 3. {{c3::K+, 5-HT, BK activate pain fibers…
Published	10/30/2023	NSAIDS as painkillers - COX catalyzes the reaction of {{c1::arachidonic acid into PG’s}} - {{c2::NSAIDS}} block COX from {{c1::making arachidonic acid…
Published	10/30/2023	ascending pathway can {{c1::interfere and influence}} descending pathway Ascending – {{c2::afferent}} ; Descending – {{c2::efferent}}
Published	10/30/2023	The gate control theory of pain (Melzack & Wall 1965) - circuit that {{c1::attenuates transmission between nociceptors & spinothalamic project…
Published	10/30/2023	Dorsal horn inhibitory interneurons – cellular effects of opioid peptides- Opioid peptides interneurons use – {{c1::Endorphins, enkephalins, dynorphin…
Published	10/30/2023	Three things opiates can do1. {{c1::Opiates decrease the duration of sensory neuron action potentials }}2. {{c2::Opiates decrease afferent e…
Published	10/30/2023	Opioid pain killers - Endogenous opioids stimulate {{c1::descending inhibition}} - Descending inhibitory pathways from different regions of the CNS ut…
Published	10/30/2023	TENS machine {{c1::stimulates large diameter touch fibers with electrodes on the skin to close the GATE}} → less pain
Published	10/30/2023	Phantom limb pain
Status	Last Update	Fields