Notes in HIV: Pathogenesis

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Published	01/07/2024	{{c1::Group-specific antigen (gag)}} of HIV is a polyprotein, contains core structural proteins, makes up inner shell and structural units of vir…
Published	01/07/2024	{{c1::Viral proteases (ex: HIV-1 protease)}} are necessary for production of infectious viral particles
Published	01/07/2024	{{c1::Integrase}} integrates a DNA copy of viral genome into host DNA during replication cycle.
Published	01/07/2024	{{c1::Env}} glycoprotein is on the surface of virus and virus-infected cells. It is composed of {{c1::gp120}} (surface binding unit, binds to CD4) and…
Published	01/07/2024	{{c1::CRISPR}} is a techology that will likely transform treatment of HIV in the future.
Published	01/07/2024	Most of the spread of HIV can be traced back to the {{c1::Congo river basin::geographical location}}
Published	01/07/2024	More likely to transmit HIV if{{c1::Breaches}} in the genital mucosal membranes (ulcers, STIs) in unexposed people{{c1::High}}er viral loads in the in…
Published	01/07/2024	Some people in {{c1::acute}} HIV infection can look like they have an AIDS-defining infection (oral candidiasis, CMV, toxoplasmosis).
Published	01/07/2024	Symptoms of {{c1::primary}} HIV infection include:Headache, sore throat, lymphadenopathy, fever, rash, pharyngitis, weight lossFlu-like or mononucleos…
Published	01/07/2024	{{c1::HIV wasting}} is significant, progressive weight loss in HIV infection due to increased energy expenditure from proinflammatory response/cytokin…
Published	01/07/2024	Level of {{c1::plasma HIV-1}} predicts rate of decline of CD4+ T cells
Published	01/07/2024	Level of {{c1::CD4+ T cells}} predicts likelihood of getting AIDS or dying
Published	01/07/2024	{{c1::Homozygous}} defect in {{c1::HIV-1 coreceptor}} accounts for resistance of some multiply-exposed individuals to HIV-1 infection.
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