Notes in O2 & Hemoglobin (11/7)

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Status	Last Update	Fields
Published	11/11/2023	Factors that affecting Hb affinity for O2 (4)
Published	11/11/2023	Factors that increase Hb/O2 affinity
Published	11/11/2023	Factors that decrease Hb/O2 affinity
Published	11/11/2023	Myocytes have a specialized oxygen-carrying protein, {{c1::myoglobin}}{{c1::Myoglobin}} is a {{c4::monomer}} and therefore does not have {{c5::coopera…
Published	11/11/2023	{{c2::Myoglobin::myoglobin or hemoglobin}} binds oxygen tighter than {{c2::hemoglobin::myoglobin or hemoglobin}} at {{c1::low}} concentrations of oxyg…
Published	11/11/2023	{{c1::Myoglobin}} acts as an oxygen reservoir for myocytes.
Published	11/11/2023	When intracellular pO2 levels decrease in times of very high muscle metabolism, oxygen is released from {{c1::myoglobin}} to the mitochondria.
Published	11/11/2023	When oxygen binds free {{c1::heme}} in solution, the oxygen quickly {{c2::oxidizes}} iron (Fe2+ → Fe3+)
Published	11/11/2023	{{c4::Bohr Effect}}‒{{c1::⇩::⇩ or ⇧}} pH increases the cooperativity which {{c2::decreases}} the oxygen binding of hemoglobin ⇒ {{c2::increases}}…
Published	11/11/2023	In myocytes, {{c1::decreasing::⇩ or ⇧}} pH {{c2::increases::⇩ or ⇧}} the amount of oxygen transferred to myoglobin.
Published	11/11/2023	Normally only about 1% of hemoglobin is methemoglobin because {{c1::cytochrome b5 reductase}} reduces the {{c2::methemoglobin}}
Published	11/11/2023	{{c1::Methemoglobinemia}} is when methemoglobin rises higher than {{c2::20}}%.
Published	11/11/2023	Type 1 Methemoglobinemia
Published	11/11/2023	Type 2 Methemoglobinemia
Published	11/11/2023	Acquired Methemoglobinemia
Published	11/11/2023	Increasing {{c1::CO₂}} & {{c1::BPG}} will decrease hemoglobin's affinity for oxygen
Published	11/11/2023	When hemoglobin contains an oxidized iron (Fe3+ ), the hemoglobin is referred to as {{c1::methemoglobin (metHb)}}
Published	11/11/2023	Fetal hemoglobin is {{c1::less}} cooperative so that O₂ can bind more tightly
Published	11/11/2023	Treatment for Methemoglobinemia
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