Notes in f. Evidence of Genetic Factors and Multifactorial Inheritance

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Published	07/28/2024	Multifactorial traits result from two components:{{c1::environmental}} factorsvariants in {{c1::multiple}} gene(s)
Published	07/28/2024	Height is a {{c1::poly::mono/poly}}genic trait
Published	07/28/2024	{{c1::GWAs}} show that while common variants can play a role in pathogenesis of genetic diseases there is also the extreme genetic heterogen…
Published	07/28/2024	What is the "common variants, common diseases" hypothesis?
Published	07/28/2024	What is the omnigenic hypothesis for multifactorial inheritance?
Published	07/28/2024	Polygenic risk scores are aggregated from {{c1::SNPs}} to provide estimate of {{c1::risk}} through {{c2::odds ratio}}
Published	07/28/2024	Drawbacks to polygenic risk scores:Doesn't identify {{c1::protective}} allelesDoesn't provide information on {{c1::treatment}}
Published	07/28/2024	What does the threshold model state for common birth defects?
Published	07/28/2024	What does recurrence risk refer to?
Published	07/28/2024	Increasing severity of disease among family members will {{c1::increase::increase/decrease}} recurrence risk
Published	07/28/2024	When the "less affected" sex for a disease is affected, there is a(n) {{c1::increased::increased/decreased}} risk to relatives
Published	07/28/2024	Why is there is an increased risk to relatives when the "less affected" sex is affected?
Published	07/28/2024	Recurrence risk to the child of the more affected sex is {{c1::higher::higher/lower}} when affected parent is of the {{c1::mo…
Published	07/28/2024	Recurrence risk is {{c1::lower::higher/lower}} with more degrees of separation from the proband
Published	07/28/2024	What is the current consensus around twins and disease concordance for multifactorial diseases?
Published	07/28/2024	Why is knowledge about Mendelian forms of common complex diseases useful?
Published	07/28/2024	How do GWAS test the "common disease, common variant" hypothesis?
Published	07/28/2024	What is the "thrifty genotype"?
Published	07/28/2024	Common birth defects:have increased risk with {{c1::more}} affected individuals in the family and higher recurrence risk if child is of {{c2::more}} f…
Published	07/28/2024	Familial aggregation:In case of cleft palate, risk {{c1::increases::increases /decreases}} if you are closer to affected relative
Published	07/28/2024	Twin studies:  • Entirely Genetic {{c1::MZ 100% DZ 50%}}• Entirely Non-genetic  {{c2::MZ = DZ << 100%}} • Multifactoria…
Published	07/28/2024	5 Diagnostic criteria of diabetes mellitus
Published	07/28/2024	Genetic causes for diseases can be identified by checking for {{c1::Linkage co-segregation of a marker locus}}{{c2::Association of phenotype with geno…
Published	07/28/2024	If a disorder was entirely genetic, concordance rates would be {{c1::100%}} for monozygotic twins and {{c2::50%}} for dizygotic twins. If disease was …
Published	07/28/2024	Epidemiologic evidence shows that both complex and infectious diseases have some rate of {{c1::disease concordance}}
Published	07/28/2024	Multifactorial diseases are different from Mendelian disorders in that they are caused by a {{c1::multitude of factors, including multiple gene mutati…
Published	07/28/2024	Common birth defects are generalized to follow a {{c1::threshold model with individual susceptibility}}
Published	07/28/2024	What are the different factors influencing inheritance of multifactorial disorder vs. mendelian trait/disorder?
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