Notes in Stem Cells HM

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Published	08/28/2024	Stem cells have three key properties:{{c1::They are undifferentiated}}{{c1::They have differentiation potential}}{{c1::They can replicate (some eviden…
Published	08/28/2024	{{c1::Totipotent Stem Cells}} have the potential to differentiate into all of the cells and tissues that make up an embryo and support its develo…
Published	08/28/2024	A {{c1::Pluripotent Stem Cell}} can give rise to cells derived from ALL three embryonic germ layers
Published	08/28/2024	A {{c1::multipotent stem cell}} is a cell in an adult that can give rise to multiple cell lineages in a single tissue/organ
Published	08/28/2024	A {{c1::unipotent stem cell}} is a cell in an adult organism that can differentiate along one cell lineage
Published	08/28/2024	Sources of {{c1::pluripotent stem cells}} are the {{c2::blastocyst inner cell mass}} and {{c2::gonadal ridges (embryonic germ cells)}}
Published	08/28/2024	Stem cell phenotype depends on both {{c1::intrinsic regulatory signals (transcription factors)}} and {{c1::extrinsic signals (provided by su…
Published	08/28/2024	{{c1::Organoids}} are small, {{c2::artificially}} grown masses of cells or tissue that resemble a specific organ
Published	08/28/2024	Developmental {{c1::plasticity}}:‐ The ability to differentiate into multiple lineages. ‐ {{c2::No directionality}} is implied (from/to). ‐ Represents…
Published	08/28/2024	The stem cell {{c1::niche}} does not supply the cells with blood or nutrients, instead supplies the cell with regulatory factors to ensure {{c2::contr…
Published	08/28/2024	Undifferentiated cells are ideal for {{c1::transplants}} because they don't express proteins characteristic of organ-specific differentiated tissue
Published	08/28/2024	Sources of {{c1::pluripotent}} stem cells are the blastocyst {{c2::inner cell mass}} (fertilized or cloned embryos) and gonadal {{c2::ridges}} (embryo…
Published	08/28/2024	In addition to intrinsic regulatory signals (transcription factors), extrinsic signals provided by surrounding cells are required to maintain the stem…
Published	08/28/2024	• {{c2::Intestinal stem cells (ISC)}} maintain four functional cell populations—(1) {{c1::absorptive}}, (2) {{c1::goblet}}, (3) {{c1::Paneth}}, and (4…
Published	08/28/2024	Differentiation most often driven by the {{c1::SAME}} intrinsic and extrinsic factors that drive normal development. Factors may be added or removed t…
Published	08/28/2024	3D culturing of embryonic and adult mammalian stem cells allow derivatives to {{c1::self‐organize}}
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