Notes in MCBD Exam 1

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Status	Last Update	Fields
Published	11/16/2023	Sickle cell anemia is caused by a _______ mutation, resulting in protein misfolding.
Published	11/16/2023	The accumulation of what causes alzheimers/huntingtons/parkinsons?
Published	11/16/2023	Histone acetylation causes an increase in ______, while methylation(histone or DNA) causes ________.
Published	11/16/2023	Essential amino acids mneumonic
Published	11/16/2023	What protein is produced by fibroblasts, epithelial cells, odontoblasts, osteoblasts, and chondrocytes and forms the organic matrix in dentin & ce…
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Published	11/16/2023	Type I collagen biosynthesis disorder causing deformity, curved long bones, and weak bones
Published	11/16/2023	Type I collagen biosynthesis disorder causing joint hypermobility, cutaneous fragility, hyperextensibility.
Published	11/16/2023	Type III collagen biosynthesis disorder causing abnormal wound healing and lots of scar tissue due to tissue overgrowth.
Published	11/16/2023	Type IV collagen biosynthesis disorder causing antibodies to be produced against collagen in lungs and kidneys.
Published	11/16/2023	Type IV collagen biosynthesis disorder causing loss of kidney function and hearing
Published	11/16/2023	Type IV collagen biosynthesis disorder causing fragile, blistering skin
Published	11/16/2023	Gingival swelling Mucocutaneous petechiae Poor wound healing Perifollicular papules Edema of lower extremities Painful hemarthrosis Brittle bones
Published	11/16/2023	Connective tissue protein – Lungs, skin, ligament, arteries Doesn’t contain hydroxylysine, thus more elastic
Published	11/16/2023	alpha-antitrypsin (AAT) does what? Its nonfunction causes what?
Published	11/16/2023	Plasma proteins are synthesized in the _____ and act as _____ to stabilize pH.
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Published	11/16/2023	-Present in heart & skeletal muscle -Oxygen reservoir - Stores O2 in muscle -Higher affinity for O2 than hemoglobin
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Published	11/16/2023	Scurvy often leads to gingival inflammation, bleeding gum, dry mouth, and bruising. What is the underlying molecular cause?
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Published	11/16/2023	Factors affecting kinetic properties of enzymes mnemonic:
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Published	11/16/2023	Vmax =
Published	11/16/2023	Km =
Published	11/16/2023	The lineweaver burk equation is the ______ form of the Michaelis-Menten equation
Published	11/16/2023	The binding of a substrate to one binding site of an enzyme affects the binding of another substrate to a different binding site of the same…
Published	11/16/2023	Allosteric enzymes have an altered ____ and ____ depending on if an activating or repressing substrate is bound.
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Published	11/16/2023	Which Lineweaver-Burk plot is caused by competetive inhibition? Non-competetive inhibition?
Published	11/16/2023	What is Km ?
Published	11/16/2023	When does Km change?
Published	11/16/2023	When does Km remain unaffected?
Published	11/16/2023	Vmax
Published	11/16/2023	When does Vmax change?
Published	11/16/2023	When does Vmax remain unaffected?
Published	11/16/2023	Elevated amylase and lipase levels in the serum suggest __________
Published	11/16/2023	Increased ____________ without increase in _____________ likely means salivary glands inflammation or acute stress. This commonly happens when salivar…
Published	11/16/2023	_________ is released when liver is damaged. This can be detected in serum(blood).
Published	11/16/2023	_____ is found in the heart, brain, and skeletal muscles. It leaks into blood when muscle tissue is damaged. Elevated levels usually indicate stress o…
Published	11/16/2023	________ is responsible for metabolizing galactose. When the enzyme is non-functional, galactose cant be metabolized and patients, usually babies, get…
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Published	11/16/2023	Which of the following is NOT part of the Triple Response of Lewis?  Tissue destruction  Vasoconstriction  Edema  Vasodilation&nbs…
Published	11/16/2023	Enzymatic diagnosis of acute pancreatitis may be achieved by testing:  Salivary amylase  Creatine phosphokinase  Alanine aminotransfera…
Published	11/16/2023	Which is a correct matching of a protein and its associated disease?  Type III Collagen - Ehlers-Danlos type IV  Type III Collagen - Epiderm…
Published	11/16/2023	These inflammatory cells are important in the fight against parasites because of Major Basic Protein.  Eosinophils  Plasma cells  Mast …
Published	11/16/2023	The main role of this enzyme during DNA replication is to provide relief from a supercoil formation.  Topoisomerase  Helicase  DNA poly…
Published	11/16/2023	Telomerase dysfunction could lead to oral leukoplakia & premature tooth loss. What is the main function of telomerase?  To reverse telomere s…
Published	11/16/2023	Cardinal signs of inflammation
Published	11/16/2023	Acute inflammation is...
Published	11/16/2023	The Triple Response of Lewis
Published	11/16/2023	Cells of acute inflammation include...
Published	11/16/2023	Chronic inflammatory cells include...
Published	11/16/2023	Macrophages in chronic inflammation...
Published	11/16/2023	Lymphocytes - B and T cells in chromic inflammation...
Published	11/16/2023	Plasma cells in chromic inflammation...
Published	11/16/2023	Eosinophils in chromic inflammaton...
Published	11/16/2023	Mast cells in chronic inflammation...
Published	11/16/2023	Granulomatous inflammation is a type of chronic inflammation that features large numbers of activated macrophages, often epithelioid macrophages, that…
Published	11/16/2023	A granuloma consists of...
Published	11/16/2023	DNA primase
Published	11/16/2023	Helicase
Published	11/16/2023	Topoisomerase
Published	11/16/2023	DNA pol III
Published	11/16/2023	DNA ligase
Published	11/16/2023	DNA polymerae I
Published	11/16/2023	Senescent
Published	11/16/2023	Topoisomerase inhibitor mechanism
Published	11/16/2023	926b74c6c5d14d4cb02a8592ffd4a3fd-oa-1
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Published	11/16/2023	3 steps to post-transcriptional modicication
Published	11/16/2023	-Small (18-25 nt) non-coding RNA molecules  -Interact with the 3 UTR of target mRNAs to ′induce mRNA degradation and  translational repressi…
Published	11/16/2023	-Heterogeneous group of RNA molecules with more than 200 nucleotides of length -Do not encode proteins
Published	11/16/2023	Production of >2 variants of a protein from the same gene:
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