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Notes in
Neurulation and Development of the PNS
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{{c1::Neurulation}} is the process wherby the {{c2::neural plate}} forms the {{c3::neural tube}}
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The {{c1::notochord}} induces the {{c2::neuroectoderm}} to form the {{c3::neural plate}} beginning in the {{c4::3rd}} week
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The {{c1::notochord}} secretes signaling molecules such as the {{c2::Sonic hedgehog protein (SHH)}}
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The {{c1::notochord}} is a solid {{c2::mesodermal}} rod
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{{c1::Secondary neurulation}} deals with the {{c2::caudal cell mass (tail bud)}}
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Neurulation top down veiw {{c1::}}
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The {{c1::cranial}} neuropore closes around day {{c2::25}}
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The {{c1::caudal}} neuropore closes around day {{c2::28}}
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{{c1::Folic acid (vitamin B9)}} is required for formation of the {{c2::neural tube}}
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{{c1::Neural Tube Defects}} are the {{c2::second}} most common congenital disability
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{{c1::Anecephaly}} is the failure of the {{c2::cranial neuropore}} to close
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{{c1::Encephalocele}} is a sac containing {{c2::brain/meniges/cerbrospinal fluid}} forms {{c2::outside the skull}}
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{{c1::Myeloschisis}} is the exposed {{c2::neural tissue}} without {{c2::skin or meninges covering}}
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{{c1::Meningocele}} is a cystic dialation of meninges containing cerbro spinal fluid {{c2::without}} neural tissue
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{{c1::Myelomeningocele}} is exposed {{c2::neural tissue and meninges}} with a fluid filled sac that protrudes from the vertebral level
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{{c1::Spina bifida occulta}} is a uncolsed {{c2::spinal arch}}
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{{c1::Fusion}} of the neural fold begins in the {{c2::cervical region (fifth somite)}}
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{{c1::Neural crest cells}} undergo {{c2::epithelial-mesenchymal-transition}} {{c3::dorasl or ventrally}}
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{{c1::Dorsal}} migrating neural crest cells form {{c2::melanocytes in the skin and hair follicles}}
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{{c1::Ventral}} migrating neural crest cells form {{c7::{{c2::sensory ganglia}}, {{c3::sympathetic neurons}}, {{c4::enteric neurons}}, {{c5::schwann c…
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{{c1::Hirschspring's}} disease is the failure of {{c2::vagal neural crest migration}} affecting {{c3::distal hindgut}}
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{{c1::Hirschprung}} disease is associated with {{c2::inability to pass first stool}}, {{c3::bilious vomiting}}, and {{c4::abdominal distension}}
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{{c1::Dorsal}} horn is {{c2::sensory/afferent}}
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{{c1::Ventral}} horn is {{c2::motor/efferent}}
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The meninges devolp from {{c1::NCC and mesenchyme::type of cell(s)}} between {{c2::20-35}} days
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At {{c1::8}} weeks the spinal cord will extend to {{c2::the end of the vertebral canal}}
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At {{c1::24}} week the spinal cord will be located at or above S1
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In {{c1::adults}} the spinal cord ends at {{c2::L1}}
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{{c1::Tethered Cord Syndrome}} is if the {{c2::spinal cord}} is attatched to the {{c3::vetebral column}}
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{{c1::Tethered cord syndrome}} can cause {{c2::motor or sensory}} dysfunction and is often characterized by {{c3:: bladder/bowel dysfunction}}
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Motor nerve fibers develope around week {{c1::4}}
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{{c1::Motor neurons}} extend from the {{c2::basal plates (ventral horns)}}
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{{c1::Dorsal nerve roots}} are positioned {{c4::{{c2::outside of the spinal cord}} in the {{c3::dorsal root ganglia}}}}
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{{c1::Schwann cells}} {{c2::myelinate}} the {{c3::peripheral nerves}}
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