Notes in 26 Lentivirus

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Status	Last Update	Fields
Published	07/30/2024	LENTIVIRUS GENERALITIESMOT: {{c1::Exchange of body fluids}}Persists {{c1::indefinitely}} in infected hostMutation rate: {{c1::high}}Progression: {{c1:…
Published	07/30/2024	LENTIVIRUS GENERALITIESVirion: spherical or cylindricalEnvelope: {{c1::present::present/absent}}Genome: {{c1::ss::ss/ds}}RNAReplication: reverse trans…
Published	07/30/2024	LENTIVIRUS GENES{{c1::gag::gene}}: Core and matrix proteins{{c1::pol}}: Enzymes for viral transcription{{c1::env}}: Surface and transmembrane proteins
Published	07/30/2024	LENTIVIRUS PROTEINS{{c1::gag::Gene}}: {{c2::p24, p17}}{{c1::pol}}: {{c2::Reverse transcriptase, integrase, protease}}{{c1::env}}: {{c2::gp120, gp41}}
Published	07/30/2024	The most efficient means of transmitting HIV is {{c1::anal}}
Published	07/30/2024	The estimated risk of transmission in needlestick injury is {{c1::< 0.3%}}
Published	07/30/2024	Aside from sexual contact and parenteral exposure, HIV can also be transmitted {{c1::vertically and through breastfeeding::2}}
Published	07/30/2024	Specimen w/ Highest titers of HIV: {{c1::blood and semen::2}}
Published	07/30/2024	4 Stages of HIV Infection:{{c1::Primary InfectionClinical LatencyClinical Disease}}Death
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROME{{c1::Acute HIV Syndrome/Acute Retroviral Syndrome}}First sign of HIV infection in {{c2::50-90%::%}} casesSymptoms a…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEDiagnosis of AIDSCD4 count of {{c1::<200}}{{c1::AIDS defining illness}} regardless of CD4 count
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEDiagnosis of AIDSLaboratory AxisClinical AxisTotal Lymphocyte CountCD4+ CountStage: 1 {{c3::Asymptomatic}}Stage 2: {…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEDiagnosis of AIDS{{c1::Stage I}}{{c2::Stage II}}{{c3::Stage III}}{{c4::Stage IV}}  {{c1:: Asymptomatic infectio…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMELaboratory Diagnosis of AIDSSerologyDetermination of antiviral {{c1::antibodies}}Most widely used screening method: …
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMELaboratory Diagnosis of AIDSWestern Blot InterpretationA: {{c1::Control strip}}B: {{c1::Indeterminate result. Reacti…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMELaboratory Diagnosis of AIDSNucleic Acid DetectionDetect {{c1::Nucleic acid}} or {{c1::Antigens}}Detectable {{c1::BE…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMELaboratory Diagnosis of AIDS{{c1::RNA levels}}: precedes a positive HIV antibody test by {{c2::11 days}}{{c1::p24 an…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMELaboratory Diagnosis of AIDSAverage window period with 3rd generation antibody test: {{c1::22 days}}Standard antigen…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMENational Diagnostic Algorithm2 parallel screening tests: {{c1::2 immuno assaysImmunoassay + Rapid Diagnostic Te…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMERapid HIV Diagnostic Algorithm (rHIVda){{c1::Western Blot}} is no longer included due to false positive or indetermi…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMERapid HIV Diagnostic Algorithm (rHIVda)Uses: {{c1::Immunoassay or Rapid Diagnostic Test}}Tests for: {{c1::HIV 1 and …
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMERapid HIV Diagnostic Algorithm (rHIVda) Test 1Test 2Test 3Non-Reactive{{c1::Repeat test after 2-6 weeks}} …
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROME EpidemiologyPhilippine dataTotal new cases as of June 2023: {{c1::1,518}}Advanced stage: {{c1::27%}}Predominant gen…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEEpidemiologyPrimary MOT: {{c1::Homosexual practice}}Secondary MOT: {{c1::Bisexual practice}}
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEEpidemiologyMOT and Percentage of Infection Among Newly DiagnosedMale-male sex: {{c1::64%}}Male-female sex: {{c1::24…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEEpidemiologyPrimary age group affected by HIV: {{c1::25-34 years}}
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEGoalsControl HIV InfectionHIV RNA load: {{c1::<20-75 copies/mL}}Restoration of immune statusCD4+ Count: {{c1::&gt…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMENatural HistoryAcute HIV Infection Syndrome: {{c1::High::High/Low}} viremia and {{c1::low::high/low}} CD4+ countSero…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEIf left untreated: CD4+ cells gradually {{c1::decline}} over the years after a period of latency and the viral …
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEHIV Replication Cycle1. Infection starts by the binding {{c1::gp120}} to the CD4+ molecule found on T cells2. {{c1::…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEAntiretroviral TherapyFusion and Entry InhibitorsPost-Attachment InhibitorsNucleotide Reverse Transcriptase Inhbitor…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROME HAART RegimenUse {{c1::Combination Therapy}}GoalsDisrupt {{c1::multiple viral processes}}Avoid development of {{c1:…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEHAART RegimenConditions that require HAART{{c1::Pregnancy, AIDS-defining conditions, Acute opportunistic i…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEHAART RegimenPreferred regimenAny of the following:{{c1::2 NRTI + NNRTI2 NRTIs + Protease Inhibitors2 NRTIs + Integr…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEStrains of HIVStrains: {{c1::HIV-1 and HIV-2}}More difficult to treat: {{c2::HIV-2}}
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEStrains of HIV HIV-1HIV-2Cases{{c1::~95%}}{{c2::~5%}}Distribution{{c1::Worldwide}}{{c2::West Africa}}Progressio…
Published	07/30/2024	ACQUIRED IMMUNODEFICIENCY SYNDROMEAntiretroviral Therapy Limitations{{c1::Not curative}} due to infected cells in latency areas{{c1::Drug resistance a…
Status	Last Update	Fields