Notes in 02_Cushing’s Syndrome and Disease

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Published	02/10/2024	{{c1::Cushing’s Syndrome}} refers to the {{c2::signs and symptoms that develop after prolonged abnormal elevation of cortisol}}.
Published	02/10/2024	{{c1::Cushing’s Disease}} is an {{c2::excessive Adrenocorticotropic Hormone (ACTH) secretion secondary to a pituitary adenoma (benign tumour)}}
Published	02/10/2024	Presentation of {{c2::Cushing’s Syndrome}} {{c1::Round moon face}}{{c1::Central obesity}}{{c1::Stretch marks (abdominal striae)}}{{c1::Bruising and sk…
Published	02/10/2024	ACTH-dependent causes of Cushing’s Syndrome{{c2::75}}% of cases involve {{c1::Pituitary tumour (Cushing’s disease)}}{{c2::5}}% of cases involve {…
Published	02/10/2024	ACTH-independent causes of Cushing’s Syndrome{{c2::20}}% of cases involve:{{c1::Adrenal tumour (adenoma or carcinoma)}} {{c1::Corticosteroid ther…
Published	02/10/2024	Tests for diagnosing {{c2::Cushing’s syndrome}} include{{c1::dexamethasone suppression test (DST)}} and {{c1::24-hour urinary free cortisol}}
Published	02/10/2024	The {{c1::dexamethasone suppression test}} is the test of choice for diagnosing {{c2::Cushing’s Syndrome}}
Published	02/10/2024	{{c1::24-hour urinary free cortisol}} can be used as an alternative to the dexamethasone suppression test for Cushing's Syndrome
Published	02/10/2024	Treatment of Choice of  Cushing’s Syndrome is {{c1::Surgery and Steroid Replacement post-operatively}}
Published	02/10/2024	Timing of Dexamethasone suppression test is given {{c1::at night (10pm)}} and measured {{c1::in the morning (9am)}}
Published	02/10/2024	If the result of low dose DST (1mg) is {{c1::low}} cortisol then {{c2::Cushing's}} can be excluded
Published	02/10/2024	If the result of low dose DST (1mg) is {{c1::high/normal}} cortisol then {{c2::Cushing's Syndrome}} is diagnosed
Published	02/10/2024	The high dose DST (8mg) is performed after an {{c1::abnormal}} result on the low dose DST (1mg).
Published	02/10/2024	If the result of high dose DST (8mg) is {{c1::low}} cortisol then {{c2::Cushing's Disease}} is diagnosed
Published	02/10/2024	If the result of high dose DST (8mg) is {{c1::high/normal}} cortisol then the diagnosis is either {{c2::Adrenal Adenoma (low ACTH)}} or {{c2…
Published	02/10/2024	Describe the Suppression of Cortisol and ACTH in Pituitary Adenoma after a DST test{{c1::Suppressed}} cortisol and {{c1::Suppressed}} ACTH
Published	02/10/2024	Describe the Suppression of Cortisol and ACTH in Adrenal Adenoma after a DST test{{c1::Unsuppressed}} cortisol and {{c1::Suppressed}} ACTH
Published	02/10/2024	Describe the Suppression of Cortisol and ACTH in Ectopic ACTH after a DST test{{c1::Unsuppressed}} cortisol and {{c1::Unsuppressed}} ACTH
Published	02/10/2024	Approach to Cushing’s Syndrome (Diagram)[1] {{c1::Screen for hypercortisolism (DST or 24-HR urinary free cortisol)}}[2] {{c1::Confirm hypercortisolism…
Published	02/10/2024	Medical treatment of Cushing’s Syndrome[1] {{c1::Adrenal hormone synthesis inhibitors (e.g. Ketoconazole)}}[2] {{c1::Adrenocortical cells destroy…
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