Notes in 8. Autonomic Nervous System

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Status	Last Update	Fields
Published	06/03/2024	SLUDE
Published	06/03/2024	PNS is stimulatory basically everywhere except the ...
Published	06/03/2024	autonomic nervous system breaks down into two systems:
Published	06/03/2024	effect of epinephrine (sympathetic agonist) on SLUDE
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Published	06/03/2024	name of enzyme that creates ACh
Published	06/03/2024	steps of NE synthesis: (enzymes in parenthesis){{c2::tyrosine}} ({{c5::tyrosine hydroxylase}}) > {{c3::L-dopa}} ({{c6::aromatic amino-acid decarbox…
Published	06/03/2024	epinephrine synthesized from ..., ... (outside/inside) the granule, by ... enzyme
Published	06/03/2024	main method of removing NE from synaptic cleft
Published	06/03/2024	relation of MAO and COMT to NE
Published	06/03/2024	sympathomimetics vs sympatholytics
Published	06/03/2024	atropine target/function
Published	06/03/2024	ACh can bind both M and N receptors, but muscarine and nicotine can only bind ...
Published	06/03/2024	Why is muscarine either inhibitory or stimulatory?
Published	06/03/2024	M2 vs M3 receptor
Published	06/03/2024	nicotinic receptors are always ... (inhib/stimul)
Published	06/03/2024	nicotine vs varenicline
Published	06/03/2024	difference in mechanism of causing neuromuscular blockage between depolarizing agents (agonists) and blocking agents (antagonists) (cholinolytic posts…
Published	06/03/2024	examples of competitive antagonists: (NMJ blocker, N-AChR)
Published	06/03/2024	examples of cholinergic agonists: (NMJ blockade, N-AChR)
Published	06/03/2024	difference between direct and indirect parasympathomimetics (increase PNS)
Published	06/03/2024	Compare and contrast the stability of covalent intermediates formed between AChE and the following: ACh (ester); NEOSTIGMINE …
Published	06/03/2024	Compare and contrast how the plant alkaloids, PILOCARPINE and ATROPINE affect XEROSTOMIA and GLAUCOMA.
Published	06/03/2024	Summarize the effect of PNS activation in the following (pupil, aqueous humor; heart, GI, bronchi), and from these PREDICT the effects of PARASYM…
Published	06/03/2024	Describe the mechanism of BoTx, and rationalize this agent’s extreme potency and long duration of action.
Published	06/03/2024	Define SYMPATHETIC TONE, and describe its relationship to the famous “FIGHT OR FLIGHT” response.
Published	06/03/2024	beta-2 receptors generally located in areas of ...
Published	06/03/2024	beta-1 receptors stimulate the ...
Published	06/03/2024	alpha-1 receptor general location/function
Published	06/03/2024	explain key points here
Published	06/03/2024	Smooth Muscle: Describe the effects of Ca2+, and cAMP on MYOSIN LIGHT CHAIN KINASE, and relate these to the PREDICTED actions of agonists an…
Published	06/03/2024	Where are chronotropic and inotropic effects observed?
Published	06/03/2024	Describe the CHRONOTROPIC and INOTROPIC effects of catecholamines, and PREDICT the pharmacological effect of β-1 agonists and antagonists on…
Published	06/03/2024	Consider a patient with both ASTHMA and ANGINA (coronary artery insufficiency). Explain the clinical significance of β-1 and β-2-selective S…
Published	06/03/2024	Demographics indicate that the US population is older and fatter than ever, suggesting DIABETES and HYPERTENSION will become increasingly common.…
Published	06/03/2024	three methods (also kind of progressions) of tachyphylaxis (beta-receptor attenuation)
Published	06/03/2024	Explain the role of CLONIDINE (α-2 agonist), and PRESYNAPTIC INHIBITION in the treatment of HYPERTENSIVE CRISIS.
Published	06/03/2024	Explain why the nasal drip of allergic rhinitis may be first ameliorated (vasoconstriction) and then exacerbated (reactive hyperemia) by nasal de…
Published	06/03/2024	Describe the common mechanism by which α-1 blockers (e.g. PHENTOLAMINE, TAMSULOSIN) can be used to hasten recovery from local anesthesia, treat s…
Published	06/03/2024	explain epinephrine reversal
Published	06/03/2024	Describe 3 distinct mechanisms by which INDIRECT SYMPATHOMIMETICS can increase the synaptic concentration of BIOGENIC  AMINES.
Published	06/03/2024	Describe the basis for using REUPTAKE INHIBITORS and MAO INHIBITORS as antidepressants, and why dietary restrictions (TYRAMINE) may sometimes be …
Published	06/03/2024	Ecstasy vs cocaine on dopaminergic transmission
Published	06/03/2024	alpha-2 receptor location/function
Published	06/03/2024	3237ec6188bd4e1abefc336b31dd78f7-ao-1
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Published	06/03/2024	f6355d7c1ee94aa1886c429c3f022ec1-ao-1
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Published	06/03/2024	98254d7329f34553a84308406a6e89da-ao-1
Published	06/03/2024	98254d7329f34553a84308406a6e89da-ao-2
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Published	06/03/2024	98254d7329f34553a84308406a6e89da-ao-4
Published	06/03/2024	PKA is activated by...
Published	06/03/2024	atropine inhibits what receptor
Published	06/03/2024	Gq-coupled receptors activate...
Published	06/03/2024	what does phospholipase C produce, and what is its effect?
Published	06/03/2024
Status	Last Update	Fields