Notes in G4 Connective Tissue

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Published	11/02/2024	Ground substance consists of
Published	11/02/2024	Why do GAGs have a high negative charge?
Published	11/02/2024	A collagen molecule is formed by three polypeptides that form a {{c1::triple helix}}
Published	11/02/2024	Insufficient or abnormal collagen synthesis results in what pathological conditions (4)?
Published	11/02/2024	Elastic fibers are produced mainly during {{c1::embryonic development}} and {{c1::adolescence}} -- resilient during human life, but many tissues gradu…
Published	11/02/2024	What can help you identify fibroblasts under microscopy?
Published	11/02/2024	During wound healing, fibroblasts can differentiate into {{c1::myofibroblasts}} that resemble {{c1::smooth muscle cells}} to aid in {{c1::wound contra…
Published	11/02/2024	What are macrophages derived from pre and post-natally?
Published	11/02/2024	List the different tissue-resident macrophages (4), and the functions that they maintain in all tissues (3):{{c1::Kupffer cells}} - liver{{c1::Mi…
Published	11/02/2024	How do macrophages participate in immune defense?
Published	11/02/2024	Mast Cells originate in the {{c1::bone marrow}}, then migrate to CT where they mature and produce characteristic {{c1::granules}}
Published	11/02/2024	Mast cells are the source of {{c1::mediators of inflammation}}, with most of them stored in granules
Published	11/02/2024	What do Mast cell granules contain?
Published	11/02/2024	What do Plasma cells do?
Published	11/02/2024	How can you identify a plasma cell?
Published	11/02/2024	Unilocular adipocytes v.s. Multilocular adipocytes
Published	11/02/2024	Fibroblasts secrete {{c1::procollagen}}
Published	11/02/2024	Mesenchyme
Published	11/02/2024	Mesenchymal cell
Published	11/02/2024	Mucous CT- present in the {{c1::umbilical cord}}- formed by {{c1::gelatinous-like ECM}}- sparse cells have {{c1::fibroblast}} morphology- ground subst…
Published	11/02/2024	What are the characteristics and functions of loose (areolar) connective tissue?- {{c1::loose network of fibers}} and many cell types- {{c1::ground su…
Published	11/02/2024	Dense CT is characterized by?
Published	11/02/2024	Dense Irregular CT
Published	11/02/2024	Dense Regular CT (tendon) can transmit what?
Published	11/02/2024	Elastic CT
Published	11/02/2024	Reticular CT- contains abundant {{c1::reticular fibers (collagen type III)}} produced by reticular cells- {{c1::reticular fibers}} are withi…
Published	11/02/2024	What type of fat is prominent in newborns?
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Published	11/02/2024	glycosaminoglycans (GAGs) are linear polymers of repeating {{c1::disaccharide units}}
Published	11/02/2024	{{c1::hyaluronic acid (hyaluronan)}} is the largest and most ubiquitous GAG
Published	11/02/2024	proteoglycans are large molecules composed of a {{c1::core protein}} with {{c1::covalently bonded GAGs}}
Published	11/02/2024	multiadhesive proteins link {{c1::ECM elements}} to the {{c1::cell surface}} by interacting with cell surface receptors
Published	11/02/2024	{{c1::Fibronectin}}, located in the reticular lamina, is the main adhesion molecule of the ECM. It has binding sites to heparin, collagen type I, II, …
Published	11/02/2024	What is the molecular structure of collagen and what contributes to its tensile strength?Collagen is a {{c1::triple helix molecule}}, rich in {{c1::gl…
Published	11/02/2024	What is the difference between collagen fibrils, fibers, and bundles?
Published	11/02/2024	Reticular fibers are very thin {{c1::collagen type III fibers}} that form a network (stroma) around the {{c1::functional cells}} (parenchyma) of organ…
Published	11/02/2024	Major types of collagen:Type I - {{c1::skin, bones, tendon}}Type II - {{c1::cartilage}}Type III - {{c1::reticular fibers}}Type IV - {{c1::nonfibrilar,…
Published	11/02/2024	Elastic fibers are formed by {{c1::networks of elastin molecules}} crosslinked by {{c1::desmosine}} and {{c1::isodesmosine}}.
Published	11/02/2024	2 types of fibers in ECM
Published	11/02/2024	categories of connective tissue cells
Published	11/02/2024	fibroblasts- most abdundant and widely distributed {{c1::fixed (resident) cells}}- {{c1::elongaged with oval nucleus::shape}} in LM
Published	11/02/2024	cells of connective tissue (6):
Published	11/02/2024	classification of connective tissue (3):
Published	11/02/2024	white fat vs brown fat
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