Notes in Cool Kidz Drugs

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Status	Last Update	Fields
Published	09/30/2024	sample {{c1::coolz}}
Published	09/30/2024	{{c1::Mesolimbic}} system connects the {{c2::ventral tegmental area}} to the {{c2::limbic forebrain}} and is involved in {{c3::psychosis}}
Published	09/30/2024	{{c1::Mesocortical}} pathway connects the {{c2::ventral tegmental area}} to the {{c2::prefrontal cortex}} and is involved in {{c3::motivation}}, {{c4:…
Published	09/30/2024	{{c1::Tuberofundibular}} pathway connects the {{c2::arcuate nucleus (hypothalamus)}} to the {{c2::pituitary stalk}} and is involved in {{c3::prolactin…
Published	09/30/2024	{{c1::Nigrostriatal}} pathway connects the {{c2::substantia nigra}} to the {{c2::striatum}} and is involved in {{c3::Parkinson's}} disease and {{c4::t…
Published	09/30/2024	Repeated drug use stimulates {{c1::dopamine}} release in the {{c2::dorsal striatum}}, which is involved in {{c3::habit}} formation
Published	09/30/2024	{{c1::Insula}} is involved in {{c2::conscious}} awareness of drug craving and harm
Published	09/30/2024	{{c1::Prefrontal cortex}} is involved in {{c2::memory}} storage (craving), judgement, willpower, and response intensity
Published	09/30/2024	Abused drugs release supraphysiologic levels of {{c1::dopamine}} onto the {{c2::nucleus accumbens}}
Published	09/30/2024	{{c1::Ventral tegmental area}} fires {{c2::dopaminergic}} neurons in repsonse to rewarding stimuli
Published	09/30/2024	All addictive drugs activate the {{c1::mesolimbic}} dopamine system
Published	09/30/2024	Dopaminergic neurons from the {{c1::ventral tegmental area}} are normally under {{c2::inhibitory}} modulation by a {{c3::GABA}}-ergic neuron, resultin…
Published	09/30/2024	{{c1::Opioids}}, {{c2::THC}}, and {{c3::GHB}} bind to {{c5::Gi/0::G-protein}} to block {{c4::Ca2+}} entry into {{c5::GABA}}-ergic interneurons
Published	09/30/2024	{{c1::Benzodiazepines}} and {{c2::ethanol}} bind to {{c3::ion channels}} on the {{c4::GABA}}-ergic interneuron to inhibit {{c4::GABA}} release
Published	09/30/2024	{{c1::Nicotine}} binds to {{c2::ion channels}} on {{c3::dopamin}}-ergic neurons in the {{c4::ventral tegmental area}} to stimulate release onto the {{…
Published	09/30/2024	{{c1::Cocaine}} and {{c2::amphetamines}} stimulate dopamine {{c3::release}} and prevent {{c3::reuptake}} in neurons in the {{c4::ventral tegmental are…
Published	09/30/2024	{{c1::Meperidine}} is a {{c2::mu}}-opioid receptor agonist that does not produce {{c3::constipation}} or {{c4::miosis}} due to its muscarinic properti…
Published	09/30/2024	{{c1::Xylazine}} is a(n) {{c2::alpha 2}}-receptor agonist used to dilute opioid powder
Published	09/30/2024	{{c1::Flunitrazepam}} is part of the {{c2::benzodiazepine}} drug class sold under the trade name {{c3::Rophynol}}
Published	09/30/2024	Side effects of Flunitrazepam (Rophynol) include {{c2::visual}} and {{c2::GI}} disturbances, {{c3::urinary retention}}, and {{c4::memory loss}}
Published	09/30/2024	{{c1::Gamma-hydroxybutyrate (GHB)}} activates {{c2::GABAB}} receptors linked to {{c3::K+}} channels, thereby causing {{c4::hyper}}-polarization of the…
Published	09/30/2024	Methaqualone is a CNS depressant that activates {{c1::GABAA}} receptors
Published	09/30/2024	Treatment for cocaine overdoses includes {{c1::Diazepam}}, {{c2::Labetolol}}, or {{c3::Ca2+ channel blockers}}
Published	09/30/2024	Why is Propranolol not used to treat cocaine overdoses? {{c1::it's a non-specific beta blocker and would cause vasoconstriction due to unmitigated alp…
Published	09/30/2024	Amphetamines enter VTA neurons through {{c1::dopamine transporters (DAT)}}, then bind to {{c2::vesicular monoamine transporters (VMAT)}} to block dopa…
Published	09/30/2024	Blocking of {{c1::VMAT}} by amphetamines causes {{c2::dopamine}} to build up in the cytoplasm and be extrasynaptically released through {{c3::DATs}}
Published	09/30/2024	In the central nervouse system, cocaine increases dopamine levels in the synaptic cleft of the VTA by blocking {{c1::dopamine transporters (DATs)…
Published	09/30/2024	In the peripheral nervous system, cocaine inhibits voltage-gated {{c1::Na+}} channels thus acting as an anesthetic
Published	09/30/2024	What drug can reduce withdrawal symptoms of nicotine? {{c1::Clonidine}}
Published	09/30/2024	What drugs can reduce nicotine cravings? {{c1::Nortriptyline and Bupropion}}
Published	09/30/2024	Stimulation of the {{c1::5-HT2A}} receptor in the {{c2::prefrontal}} cortex accounts for many of the classic psychedlic effects
Published	09/30/2024	Stimulation of the {{c1::5-HT1A}} receptor has a modulatory role in {{c2::mood}} and {{c2::anxiety}}, thereby contributing to the overall psychedelic …
Published	09/30/2024	NMDA is a {{c1::glutamate}} receptor
Published	09/30/2024	Ketamine, PCP, dextromorphan, and salvia are {{c1::NMDA}}-receptor {{c2::antagonists}}
Published	09/30/2024	Salvinorin A is a {{c1::kappa}}-opioid receptor {{c2::agonist}} that induces intense hallucinations
Published	09/30/2024	The serotonin 5-HT2A receptor is coupled to {{c1::Gq::G-protein}}, which activates {{c2::phospholipase C (PLC)}} to increase intracellular {{c3::…
Published	09/30/2024	5-HT2A receptors are found in the {{c1::prefrontal cortex}}, {{c2::hippocampus}}, and {{c3::thalamus}} in the brain
Published	09/30/2024	The {{c1::Default Mode Network}} is a system of {{c2::self-referential}} thinking and {{c3::memory recall}}
Published	09/30/2024	Key regions of the Default Mode Network are the {{c1::medial prefrontal cortex}}, {{c2::posterior cingulate cortex}}, {{c3::precuneus}}, {{c4::angular…
Published	09/30/2024	The {{c1::Central Executive}} Network controls working memory, decision-making, and problem-solving
Published	09/30/2024	The {{c1::Salience}} Network detects/prioritizes important stimuli and switches between the {{c2::Default Mode}} Network and the {{c2::Central Executi…
Published	09/30/2024	Balance between the {{c1::Default Mode}} and {{c1::Central Executive}} networks is cruical for optimal cognitive function
Published	09/30/2024	Key regions of the Salience network are the {{c1::anterior insula}} and {{c2::anterior cingulate cortex}}
Published	09/30/2024	Key regions of the Central Executive Network are the {{c1::dorsolateral prefrontal cortex}} and {{c2::posterior parietal cortex}}
Published	09/30/2024	Hallucinogens disrupt connections in the {{c1::Default Mode}} Network, leading to {{c2::altered perceptions}}, {{c3::ego dissolution}}, and {{c4::less…
Published	09/30/2024	Hallucinogens increase {{c1::glutamate}} release in the cortex by enhancing excitatory {{c2::a}}-fferent input via presynaptic {{c3::serotonin}} recep…
Published	09/30/2024	LSD activates the {{c1::5-HT2A}} receptor bound to {{c2::Gq::G-protein}}, which causes increased intracellular {{c3::Ca2+}} concentrations
Published	09/30/2024	Are hallucinogens associated with dependence and/or addiction? {{c1::fuck no baby, hallucinogens ftw}}
Published	09/30/2024	THC binds to {{c1::CB1}} and {{c1::CB2}} receptors, which are linked to {{c2::Gi/0::G-protein}} and inhibit {{c3::adenylyl cyclase}} activity
Published	09/30/2024	{{c1::K2/spice}} are synthetic {{c2::cannabinoids}} and full {{c3::agonists}} of {{c4::CB1}} receptor, leading to intense and unpredictable psychotrop…
Status	Last Update	Fields