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Notes in
Lecture 20
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03/09/2024
Define peripheral and central tolerance and discuss theirimportance in regulation of immune response.
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03/09/2024
Differentiate between mechanisms of B cell- and T cell-tolerance.
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Discuss how antigens can cause tolerance.
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Explain how maternal immunity prevents successfulvaccination of newborn animals.
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Discuss characteristics and functions of Treg cells.
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Explain how Treg and Th17 cells regulate immune responses.
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What is tolerance?
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Why is it important to regulate the immune system? What happens if it is too high or too low?
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How is developing T cells exposed to self antigens in the thymus?
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What leads to peripheral T-cell Tolerance? pg11
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What is anergy? pg 11
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How is anergy stimulated? pg 11
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What are Tolerogenic Self-Antigens VS Immunogenic Foreign Antigens? pg 18
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What is central B cell tolerance? pg 19
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Why are B-cells more likely to become self reactive than T cells? pg 19
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Why do we vaccinate animals at a few weeks old? pg21
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How do we regulate this T cell response? pg 23
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What is T regs? pg24
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What do T regs express? pg 24
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What is foxp3? pg 24
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What is a Natural Treg cells (nTreg)?
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What is a Induced Treg cells (iTreg)?
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What is the function of the cytokine TGF-B? pg 27
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What is the function of the cytokine IL-10? pg 27
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What is the function of the cytokine IL-35? pg 27
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What cytokines are immunosuppressive mediators? pg 27
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Explain tolerance in Dizygotic twins? How is this different from Monozygotic?
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03/09/2024
What would be expected if there was an absence of Tregs in the body?
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03/09/2024
What is unique to expression in terms of Tregs?
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