Notes in Week 4 - Pulmonary Meds Part 1

To Subscribe, use this Key

Status	Last Update	Fields
Published	05/29/2025	what is the gene that is mutated in cystic fibrosis?
Published	05/29/2025	what is the primary problem in the lungs with cystic fibrosis?
Published	05/29/2025	what is critical to maximize the absorption and effect of cystic fibrosis medications?
Published	05/29/2025	what type of formulatory of medications is the cornerstone of treatment for CF?
Published	05/29/2025	what are the common organisms to cause intermittent lung infection in CF patients?
Published	05/29/2025	what organism causes a more rapid decline in pulmonary function if a patient with CF is infected?
Published	05/29/2025	what is the standard treatment for for intermittent lung infection in CF patients?
Published	05/29/2025	what is the treatment for a CF infection who is infected with pseudomonas?
Published	05/29/2025	what is recommended for CF patients with chronic pseudomonas lung infection?
Published	05/29/2025	how does azithromycin help with chronic pseudomonas lung infections if it has no bactericidal activity against it?
Published	05/29/2025	MOA of bronchodilator
Published	05/29/2025	{{c1::albuterol}} is an example of a bronchodilator
Published	05/29/2025	MOA 7% hypertonic saline
Published	05/29/2025	ADR of hypertonic saline
Published	05/29/2025	what medication is classified as a recombinant human deoxyribonuclease I?
Published	05/29/2025	MOA of Dornase alfa (Pulmozyme)
Published	05/29/2025	what is the benefit of Dornase alfa (Pulmozyme)
Published	05/29/2025	C/I to Dornase alfa (Pulmozyme)
Published	05/29/2025	ADR of Dornase alfa (Pulmozyme)
Published	05/29/2025	what should NOT be done when using Dornase alfa?
Published	05/29/2025	what inhaled antibiotics target pseudomonas?
Published	05/29/2025	MOA of tobramycin
Published	05/29/2025	what age is tobramycin and aztreonam approved for?
Published	05/29/2025	ADR of tobramycin
Published	05/29/2025	frequency for taking tobramycin
Published	05/29/2025	MOA of aztreonam
Published	05/29/2025	ADR of aztreonam
Published	05/29/2025	what oral antibiotic is used to decrease inflammation and exacerbation for pseodomonas lung infection?
Published	05/29/2025	ADR of azithromycin
Published	05/29/2025	what is the pathophysiology of CF related diabetes (CFDR)?
Published	05/29/2025	treatment for CF Related Diabetes (CFDR)
Published	05/29/2025	what enzyme is deficient in CF patients with pancreatic insufficiency?
Published	05/29/2025	what  Fat-soluble vitamin deficiencies are there in CF patients?
Published	05/29/2025	how is pancreatic insuffiency managed in CF patients?
Published	05/29/2025	is the ratio of lipase, amylase, and protease the same in all PERT products?
Published	05/29/2025	how does PERT help CF patients?
Published	05/29/2025	what is the PERT used?
Published	05/29/2025	what is unique about pancrealipase formulations?
Published	05/29/2025	what is the dosing for pancrealipase based on?
Published	05/29/2025	what is the adjustment for pancrealipase dosing?
Published	05/29/2025	PERT - PANCREALIPASEInitial dosing: < 1 year: {{c1::varies by product}}Age 1-3 years: lipase {{c1::1000}} units/kg/mealAge greater than or equ…
Published	05/29/2025	what is the max dose of pancrealipase in ALL agges?
Published	05/29/2025	why do you not exceed doses greater than 6000 units/kg meal of pancrealipase?
Published	05/29/2025	warnings for Pancrealipase
Published	05/29/2025	ADR of Pancrealipase
Published	05/29/2025	what reproductive complications can arise with CF patients?
Published	05/29/2025	CFTR defect in the {{c1::cholangiocytes}} leads to {{c1::bile duct}} obstruction and sludging which can lead to fibrosis and cirrhosis
Published	05/29/2025	what is the treatment for bile duct obstruction in CF patients?
Published	05/29/2025	MOA of  Ursoidol (Actigall)
Published	05/29/2025	what medications revolutionized CF since it specifically targeted the underlying genetic mutation of CFTR?
Published	05/29/2025	what must be tested prior to using transmembrane conductance regulator (CFTR) modulators?
Published	05/29/2025	what is the most common mutation of CF?
Published	05/29/2025	when does neonatal respiratory distress syndrome occur?
Published	05/29/2025	who typically has a higher chance of experiencing neonatal respiratory distress syndrome?
Published	05/29/2025	Fetus begins to produce lung surfactant around week {{c1::20}} of gestation and is producing an adequate amount by week {{c1::35}}
Published	05/29/2025	what causs neonatal respiratory distress syndrome?
Published	05/29/2025	what do most neonates born before 35 weeks of gestation receive?
Published	05/29/2025	what surfactant products are given to neonates?
Published	05/29/2025	what formulation are surfactants given?
Published	05/29/2025	if a neonate remains intubated and continues to require oxygen to maintain adequate oxygenation, what are the next steps (surfactant was administered …
Published	05/29/2025	MOA of surfactants
Published	05/29/2025	what can be given to mother who are at risk of preterm delivery?
Published	05/29/2025	what pathogen is responsible for majority of bronchiolitis cases?
Published	05/29/2025	what is the treatment for bronchiolitis?
Published	05/29/2025	what is the difference between bronchiolitis vs croup?
Published	05/29/2025	what is the treatment for croup?
Published	05/29/2025	what steroid is used for tx of croup?
Published	05/29/2025	In an acute setting, a patient with difficulty breathing may be given what in addition to the steroid?
Published	05/29/2025	MOA of epinephrine
Published	05/29/2025	what is the duration of action of nebulized racemic epinephrine?
Published	05/29/2025	is antibiotics used for tx of croup?
Published	05/29/2025	what is Community Acquired Pneumonia (CAP)?
Published	05/29/2025	what is the most common causes of CAP?
Published	05/29/2025	what are CAP treatment considerations?
Published	05/29/2025	what does outpatient CAP treatment require?
Published	05/29/2025	what is the selection of an empiric regimen based on with inpatient CAP treatment?
Published	05/29/2025	inpatient CAP tx for non-severe (not admitted to the ICU)
Published	05/29/2025	inpatient CAP treatment for severe (admitted to the ICU)
Published	05/29/2025	what is the difference between Hospital Acquired (HAP) and VentilatorAssociated Pneumonia (VAP)?
Published	05/29/2025	how can VAP incidence be decreased?
Published	05/29/2025	what is the common pathogens in HAP and VAP?
Published	05/29/2025	what is the treatment duration for HAP/VAP?
Published	05/29/2025	what is the treatment for HAP/VAP?
Published	05/29/2025	what antibiotics can be used for HAP/VAP?
Published	05/29/2025	what is added for MRSA coverage in HAP/VAP tx?
Published	05/29/2025	what are RF for MRSA in HAP/VAP patients?
Published	05/29/2025	what are examples of abx combinations to cover for pseudomonas, MSSA, and MRSA in HAP/VAP tx?
Published	05/29/2025	what is recommended for HAP/VAP tx if there is risk for MDR gram neg pathogens?
Published	05/29/2025	what are RF for MDR-gram negative pathogens?
Published	05/29/2025	what antibiotics are used for pseudomonas?
Published	06/01/2025	Acute OM S/S
Published	06/01/2025	{{c1::Acute OM}} is the most common childhood infection in the US and is often caused by {{c1::viruses}}
Published	06/01/2025	Bacteria that can cause Acute OM
Published	06/01/2025	Non-severe acute OM is characterized by otalgia {{c1::<48hrs}}, {{c1::no otorrhea}}, and temp {{c1::<102.2F}} and:age 6-23 months: Sx in {{c1::o…
Published	06/01/2025	When are Abx inidcated for acute OM?
Published	06/01/2025	Abx treatment duration<2yrs: 10 days2-5yrs: 7 days≥6yrs: 5-7 days
Published	06/01/2025	1st line tx for acute OM
Published	06/01/2025	Alternative Tx for acute OM
Published	06/01/2025	What should you treat a pt who has failed 1st line or alternative tx options for acute OM?
Published	06/01/2025	Tx for the common cold
Published	06/01/2025	{{c1::Influenza}} has peak activity during late Nov to March. It spreads via respiratory droplets and a person can be contagious one day prior to deve…
Published	06/01/2025	Recommendations to receiving the influenza vaccine?
Published	06/01/2025	When are anti-virals indicated for the flu?
Published	06/01/2025	Tx for influenza consists of {{c1::symptomatic care}} +/- {{c1::antiviral therapy}} (need to meet criteria)
Published	06/01/2025	Antiviral options for Influenza
Published	06/01/2025	Tamiflu, Zanamivir, and Peramivir MOA
Published	06/01/2025	Influenza antivirals are active against influenza A and B and decreases the duration of Sx by about {{c1::one day.}} However, they need to be started …
Published	06/01/2025	Tamiflu requires a renal dose adjustment when {{c1::CrCl <60mL/min}}
Published	06/01/2025	Tamiflu Warnings
Published	06/01/2025	Tamiflu ADRs
Published	06/01/2025	Zanamivir (Relenza Diskhaler) Warnings
Published	06/01/2025	Zanamavir (Relenza Diskhaler) ADRs
Published	06/01/2025	Peramivir (Rapivab) requires a renal dose adjustment when {{c1::CrCl <50mL/min}}
Published	06/01/2025	Peramivir (Rapivab) Warnings
Published	06/01/2025	Peramivir (Rapivab) ADRs
Published	06/01/2025	Which antiviral is most commonly used for influenza?
Published	06/01/2025	What is tuberculosis?
Published	06/01/2025	Mycobacterium tuberculosis is an {{c1::aerobic, non-spore forming bacillus}} which primarly infects the {{c1::lungs}} but can spread to other organs
Published	06/01/2025	Active TB is transmitted via {{c1::aerosolized droplets}} (sneezing, coughing, talking)
Published	06/01/2025	Active TB is highly contagious and often presents with:
Published	06/01/2025	Pts who have active TB infection and are hospitalized may require isolation in a {{c1::single negative pressure room}}
Published	06/01/2025	In {{c1::latent TB}}, the immune system is able to contain the infection and the pt lacks symptoms
Published	06/01/2025	How can you dx latent TB infection?
Published	06/01/2025	What is the difference between a TST and IGRA?
Published	06/01/2025	Any pt with a positive TST or IGRA should be screened for the presence of active TB infection {{c1::before}} latent TB tx is initiated
Published	06/01/2025	What is Directly Observed Therapy (DOT)?
Published	06/01/2025	Active TB Tx can be divided into two phases: {{c1::intensive & continuation}}
Published	06/01/2025	In pts with active TB, the intensive regimen is preferred aka {{c1::"RIPE" therapy}}
Published	06/01/2025	What is the RIPE therapy?
Published	06/01/2025	What is the continuation phase/therapy for active TB?
Published	06/01/2025	When you see rifampin think {{c1::DRUG INTERACTIONS}}, so always check!!
Published	06/01/2025	Rifampin can decrease the concentration and therapeutic effect of many drugs, including: {{c1::protease inhibitors}}, {{c1::warfarin}}, and {{c1::OCPs…
Published	06/01/2025	DO NOT use rifampin with {{c1::apixaban}}, {{c1::rivaroxaban}}, {{c2::edoxaban}}, or {{c2::dabigatran}}
Published	06/01/2025	Children with active TB indicate an {{c1::unidentified contagious adult/adolescent}} with active TB
Status	Last Update	Fields