Notes in 05_Sickle Cell Disease

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Published	02/10/2024	{{c1::Sickle Cell Anaemia}} is an {{c2::autosomal recessive condition with an abnormal beta-globin gene on Chr11 causing abnormal variant of Haemoglob…
Published	02/10/2024	Presentation of {{c2::Sickle Cell Anaemia}}Depends on whether the person has the trait (HbAS) or the disease (HbSS) {{c1::Chronic haemolytic anaemia …
Published	02/10/2024	Features on Investigation of Sickle Cell Disease {{c1::Haemolytic anaemia (Low haemoglobin, High reticulocytes, increased unconjugated bilirubin and L…
Published	02/10/2024	Managing Acute Events of Sickle Cell Disease (i.e. Sickle Cell Crisis){{c1::Oxygen}}{{c1::IV fluids}}{{c1::Antibiotics}}{{c1::Analgesia (Paracetamol/I…
Published	02/10/2024	{{c1::Penthidine}} should not be used as analgesia in Sickle Cell Disease as it is toxic
Published	02/10/2024	{{c1::Blood transfusion (episodic or chronic)}} reduces frequency of Sickle Cell Crises but there is a risk of iron overloading which should be manage…
Published	02/10/2024	{{c1::Hydroxycarbamide}} is used to manage Sickle Cell Disease by raising the concentration of {{c2::Foetal Haemoglobin}}
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