Notes in G06 - Bone formation and repair

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Published	08/20/2024	8845862106364570b1e37555bee1cc03-ao-1
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Published	08/20/2024	With the exception of the {{c1::clavicle}}, most bones formed by intrammembranous ossification are {{c1::flat}} bones
Published	08/20/2024	A mesenchymal cell has differentiated into an osteoblast when it begins to {{c1::secret osteoid}}
Published	08/20/2024	Osteoblasts differentiate into osteocytes when {{c1::they become entrapped in the osteoid}}
Published	08/20/2024	{{c1::Fontanelles}} are areas of incomplete intramembranous ossifications of the skull
Published	08/20/2024	The primary ossification center is formed during {{c1::the 7th week of embryonic development}}. The second ossification zones are formed {{c1::after b…
Published	08/20/2024	Do the secondary ossification centers form at the same time?{{c1::No, they typically form one at a time}}
Published	08/20/2024	In the zone of {{c1::hypertrophy}}, chondrocytes cease proliferating and begin to expand their cytoplasms and mineralize the ECM
Published	08/20/2024	Hypertrophic cartilage initiates mineralization through the secretion of {{c1::VEG-F}}, {{c1::collagen X}}, and {{c1::ALP}}
Published	08/20/2024	The epiphyseal growth plate grows through {{c1::interstitial}} growth only
Published	08/20/2024	Epiphyseal growth plate growth is upregulated by {{c1::IGF-1}} secreted from the {{c1::liver}} in response to {{c1::GH}}
Published	08/20/2024	Bone growth stops with the decrease of {{c1::GH}} release that leads to a decrease in synthesis of {{c1::IGF-1}}. This decreases the rate of {{c2::eph…
Published	08/20/2024	Do epiphyseal growth plates change in thickness?{{c1::No}}
Published	08/20/2024	Why does the articular cartilage not ossify during endochondral ossification?{{c1::it lacks a perichondrium }}
Published	08/20/2024	Following bone fracture, an inital mesh of {{c1::reticular fibers}} referred to as {{c1::granulation}} tissue is laid
Published	08/20/2024	Is bone fracture repair more reminiscent of endochondral ossification or intramembranous?{{c1::Endochondral ossification}}
Published	08/20/2024	Gigantisim is caused by {{c1::GH-secreting adenoma}} that forms prior to {{c1::fusion of the epiphyseal growth plates}}
Published	08/20/2024	Acromegaly is caused by a {{c1::GH-secreting adenoma}} after {{c1::growth plates have fused}}
Published	08/20/2024	Acromegaly typically causes expansion of the {{c1::hands}}, {{c1::feet}}, and {{c1::jaw}} as well as {{c1::organo}}megaly
Published	08/20/2024	{{c1::Achondroplasia}} is the most common cause of dwarfism and is caused by a {{c1::FGFR3}} gene defect
Published	08/20/2024	Endochondral ossification is intiated by the formation of the bony collar which involves the conversion of {{c1::periochondrium}} to {{c1::periosteum}…
Published	08/20/2024	Growth plates form with the formation of the {{c1::secondary ossification centers}}
Published	08/20/2024	Perichondrium can be found lining the {{c1::nonarticulatory}} surfaces of long bone cartilage
Published	08/20/2024	Vitamind D deficiencies will cause the expansion of the {{c1::osteoid}}
Published	08/20/2024	Collagen 1 can be synthesized by fibroblasts and {{c1::osteoblasts}}
Published	08/20/2024	Calcitonin is secreted by the {{c1::thyroid gland::organ}} in response to {{c1::hypercalcemia}}
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