Notes in Renal Glomerular Diseases

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Published	10/05/2023	glomerular diseases are on a spectrum:{{c1::nephrotic}} (proteinuria, hyperlipidemia, hypoalbuminemia, edema) ←→ {{c1::nephritic}} (hematuria, decreas…
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Published	10/05/2023	assessing glomerular cellularity{{c1::mesangial cell proliferation}}: excessive growth of mesangial cells around the glomerulus *capillaries are …
Published	10/10/2023	CASE: *more nephrotic than nephritic becuase more {{c1::proteinuria}} than {{c1::hematuria}} Inital glomeruli biopsy:   …
Published	10/05/2023	more RBC and WBC in urine → surrogates for inflammation → more {{c1::nephritic}} than {{c1::nephrotic}}
Published	10/05/2023	when looking at glomerular histology consider the following:1) are the changes global or segmental (some areas of glomerulus only)? 2) is it norm…
Published	10/05/2023	pathophysiology of renal amyloidosis- {{c1::plasma cell}} disorder: excessive production of immunoglobin light chains....- chronic {{c2::inflammation}…
Published	10/10/2023	CASE:- tea-colored urine = hematuria - weight gain due to {{c2::fluid retention}}- RBC casts upon sediment analysis → more nephritic&nb…
Published	10/05/2023	Pathophysiology of post-streptococcal glomerulonephritisprocess: streptococcal infection → {{c1::antigens}} produced → antibodies produced agains…
Published	10/05/2023	CASE:- abdominal distension = {{c1::ascites}}*more nephrotic than nephritic Inital glomeruli biopsy:  - {{c6::cellularity}} i…
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Published	10/05/2023	Pathophysiology of edema- damage to {{c1::basement membrane}} in glomerulus → leakage of proteins (including albumin, results in {{c2::hypoalbuminemia…
Published	10/05/2023	Complication of patient with {{c5::nephrotic}} syndrome: renal vein {{c1::thrombosis}}  - process: along with loss of albumin, glo…
Published	10/05/2023	CASE:- {{c1::minimal change}} disease = not much damage or other changes at level of glomerulus → more nephrotic*nephrotic syndrome with normal lookin…
Published	10/05/2023	CASE:- gross hematuria, RBC casts, some proteinuria → {{c1::nephritic}} syndrome- expansion of {{c2::mesangium}} (central part where capillaries …
Published	10/05/2023	CASE:  - {{c3::nodular}} acellular pattern of mesangium matrix- no {{c2::immune}} deposits so Ig staining would be negative - {{c4::thi…
Published	10/05/2023	CASE:     - (left image, H&E): {{c2::proteinacous}} material in one segment/area of glomerulus   - (right image…
Published	10/05/2023	CASE:   - endocapillary hypercellular and non-{{c2::exudative}} - thickened and {{c3::double}}-layered membrane with abnormal depo…
Published	10/05/2023	CASE: - hematuria and proteinuria- RAPIDLY detoriating renal funciton - hypercellular - daignosis: {{c1::rapidly progressive glomerulon…
Published	10/05/2023	{{c1::alport syndrome}} is a genetic kidney disease with loss of hearing and eye abnormalities genetic mutation → affects collagenkidney looks …
Published	10/09/2023	Summary of glomerular diseases{{c1::minimal change disease}} ←→ effacement of foot processes of podocytes{{c2::membranous nephropathy}} ←→ t…
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