Notes in PHAR117 Li L01

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Published	10/04/2023	History and Importance of Partition CoefficientFound the {{c1::correlation between partition coefficient and drug potency}} in 1899.Used as a {{c…
Published	10/04/2023	Partition Coefficient is defined as {{c1:: K = [Organic Phase]/[Aqueous Phase]}}{{c2::Organic phase uses octanol for reference}}{{c3::Distributio…
Published	10/04/2023	Partition Coefficients, K or logPDistribution of an {{c1::unionized compound between two immiscible liquid phases at equilibrium.}}often expressed as …
Published	10/04/2023	Other solvents to determine Partition Coefficients{{c1::chloroformetherhexane}}
Published	10/04/2023	Why do we use octanol as the primary solvent for determining partition coefficients?
Published	10/04/2023	Partitioning of Weak ElectrolytesExpression of {{c1::partition}} coefficient is valid for {{c1::non-electrolytes.}}Expression of {{c2::distribution}} …
Published	10/04/2023	K and DBoth are distribution constantsSame for unionized compoundsK relates to {{c1::unionized or neutral compounds.}}D is only used for {{c2::ionizab…
Published	10/04/2023	Extraction is defined as the {{c1::efficiency with which one solvent extracts a compound from another immiscible solvent is dependent upon the di…
Published	10/04/2023	Extraction Formula (need to add picture)
Published	10/04/2023	Multiple ExtractionsExtraction efficiency can be improved by {{c1::extracting multiple times using same volume of extracting solvent}}Comparison30 mL …
Published	10/04/2023	Log P Values appropriate for sites of absorptionCNS - {{c3::2}}Oral/Gastrointestinal - {{c3::0-3}}Skin - {{c3::3-4}}Higher logP = {{c1::more lipophili…
Published	10/04/2023	LogP and BiopharmaceuticslogP between {{c1::0-3}}: good oral absorptionHigh logP (log P >4): {{c2::retained in lipophilic region, e.g., deposit in …
Published	10/04/2023	Top Drug Distribution with logP ValuesLess than 0 - {{c1::16%}}Between 0 and 3 - {{c1::50%}}Greater than 3 - {{c1::34%}}
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